Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease BEFREE Atorvastatin (ATO) is a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor widely used to treat hypercholesterolemia. 31423616 2019
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease BEFREE Statins inhibiting 3-hydroxy-3-methylglutaryl-CoA reductase are the standard treatment for hypercholesterolemia in atherosclerotic cardiovascular disease (ASCVD), mediated by inflammatory reactions within vessel walls. 31330988 2019
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease BEFREE The present study aimed to explore the role of sterol regulatory element binding protein (SREBP)‑2 and 3‑hydroxy‑3‑methylglutaryl CoA reductase (HMGCR) in hypercholesterolemia susceptibility in gerbils. 29257228 2018
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 GeneticVariation disease BEFREE Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are the most commonly prescribed therapeutic agents for treating hypercholesterolemia globally. 30120976 2018
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 AlteredExpression disease BEFREE We concluded that, to compensate for intrauterine placentally derived decreases in fetal blood cholesterol levels, high intrauterine GC levels activated fetal hepatic CCAAT enhancer binding protein α signaling and down-regulated Sirtuin1 expression, which mediated the high levels of histone acetylation ( via H3K9ac and H3K14ac) and expression of HMGCR. 29718709 2018
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease BEFREE It was reported that statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase that are used to prevent hypercholesterolemia, have antitumor activity in several cancers. 29290960 2017
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease BEFREE Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase and are an important group of hypolipidaemic drugs, widely used in the treatment of hypercholesterolaemia and cardiovascular disease. 25444240 2015
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 GeneticVariation disease BEFREE In this population-based case-control study, the frequencies of -911 C>A polymorphism (rs3761740) of the HMGCR gene in patients with coronary heart disease (CHD) and healthy subjects were investigated and the correlations between the different genotypes and hypercholesterolemia with cardiovascular risk factors were analyzed. 23933271 2013
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 GeneticVariation disease BEFREE Pharmacotherapy is an important and effective treatment modality for hypercholesterolaemia, with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors ('statins') the most commonly used class of drugs. 23568333 2013
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease BEFREE Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are well established in the treatment of hypercholesterolaemia and the prevention of coronary artery disease. 19884908 2010
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease BEFREE Here we describe how these studies lead to the discovery that HMGCR alternative splicing of exon 13 is not only a marker, but also a determinant of statin efficacy; not only for the treatment of hypercholesterolemia, but also as a chemopreventive agent for colorectal cancer. 20587337 2010
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 AlteredExpression disease BEFREE We have previously demonstrated that 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (HRIs), which are widely used to reduce the serum cholesterol levels in hypercholesterolemia patients, decreases survivin expression in colon cancer cells. 18815881 2009
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease BEFREE Competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (the statins) that inhibit the synthesis of mevalonic acid are in wide use for treatment of hypercholesterolemia. 18337644 2008
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease RGD Ameliorative effect of Chlorophytum borivilianum root on lipid metabolism in hyperlipaemic rats. 17250646 2007
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease BEFREE These results suggest that the HMGCR gene may serve as a modifier gene for hypercholesterolemia in Chinese diabetic patients. 17870053 2007
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease LHGDN These results suggest that the HMGCR gene may serve as a modifier gene for hypercholesterolemia in Chinese diabetic patients. 17870053 2007
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease BEFREE 3-Hydroxy-3-methylglutaryl coenzyme A reductase deregulation and age-related hypercholesterolemia: a new role for ROS. 15992608 2005
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 AlteredExpression disease LHGDN The results of the present study, obtained by one-step RT-PCR assay, demonstrated that both SOD1 and the metal-free form of enzyme (Apo SOD1) inhibit HMG-CoA reductase gene expression in hepatocarcinoma HepG2 cells, in normal human fibroblasts, and in fibroblasts of subjects affected by familiar hypercholesterolemia. 15473258 2004
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease BEFREE Cerivastatin is used in the treatment of hypercholesterolemia to inhibit 3-hydroxy 3-methylglutaryl coenzyme A reductase and thus prevent the synthesis of cholesterol precursors, such as farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), responsible, respectively, for translocation of Ras and Rho to the cell membrane, a step required for their cell signaling, leading to cell proliferation and migration. 11470741 2001
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease CTD_human Currently available hypolipidaemic drugs and future therapeutic developments. 8593127 1995
Entrez Id: 3156
Gene Symbol: HMGCR
HMGCR
0.600 Biomarker disease BEFREE The activity of the rate-limiting enzyme for cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A reductase, rapidly increases as the cells are incubated in lipoprotein-deficient medium, until, by 12 h, cells from patients heterozygous for familial type IIa hypercholesterolaemia are clearly distinguished from other hyperlipoproteinaemias. 208584 1978