| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.540 | Biomarker | disease | BEFREE | These results indicate that increased serum leptin concentrations and hyperlipidemia (hypercholesterolemia or hypertriglyceridemia) are associated with canine cholelithiasis and that homeostatic imbalance of these parameters might affect the pathogenesis of gallstones. | 29088261 | 2017 | ||||
|
0.540 | AlteredExpression | disease | BEFREE | However, HDL cholesterol and leptin levels were not altered in patients <i>v.</i> controls.<b>Conclusions</b>Total and LDL cholesterol levels are reduced in FEP, indicating that hypercholesterolaemia in patients with chronic disorder is secondary and potentially modifiable. | 28982658 | 2017 | ||||
|
0.540 | AlteredExpression | disease | BEFREE | Dietary supplementations of 0.5% and 1% RHSE resulted in a reduction at the end of the 7-week feeding study of body weight gain of 66.9% and 72.5%, respectively, a reduction of epididymal white adipose tissue weight by up to 87.9%, restoration of elevated total cholesterol and triglyceride levels in plasma and liver to those observed in the ND-fed mice, normalization of distorted serum leptin and adiponectin levels, and restoration of liver weight and glutamate oxaloacetate transaminase/glutamate pyruvate transaminase (GOT/GPT) enzymes, blood urea, and serum creatinine to the normal control levels observed in the ND-fed mice. | 26190448 | 2015 | ||||
|
0.540 | Biomarker | disease | CTD_human | Oral administration of Nitraria retusa ethanolic extract enhances hepatic lipid metabolism in db/db mice model 'BKS.Cg-Dock7(m)+/+ Lepr(db/)J' through the modulation of lipogenesis-lipolysis balance. | 25086370 | 2014 | ||||
|
0.540 | GeneticVariation | disease | BEFREE | Our results suggest that the G-308A polymorphism of the TNF-α gene may be independently associated with hypertension, leptin level and hypercholesterolemia leading to metabolic syndrome independent of Insulin resistance and hyperglycemia. | 21616679 | 2012 | ||||
|
0.540 | Biomarker | disease | RGD | Creation and preliminary characterization of a leptin knockout rat. | 22948215 | 2012 |