Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Value of Measuring Lipoprotein(a) During Cascade Testing for Familial Hypercholesterolemia. 30846097 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE High levels of lipoprotein(a), through corresponding low LPA KIV-2 number of repeats rather than through high cholesterol content were associated with high risk of mortality.These findings are novel. 30608559 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Lipoprotein apheresis reliably reduces low-density lipoprotein (LDL) cholesterol in patients with atherosclerotic disease and therapy-refractory hypercholesterolemia or elevated lipoprotein (a) (Lp(a)). 30744123 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Apheresis for severe hypercholesterolaemia and elevated lipoprotein(a). 30611543 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Among 10 studies that included 407 patients with surgically proven endometriosis and 557 controls, RR of developing hypercholesterolemia and hypertension were 1.25 and 1.14, respectively, while higher serum lipoprotein a and lower paraoxonase 1 levels were found in women with endometriosis that was negatively correlated with stage of disease (r = -0.74, P < 0.0001). 31735549 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE In this study, a cohort of 110 patients with established atherosclerotic cardiovascular disease (ASCVD) due to hypercholesterolemia or concomitant lipoprotein(a)-hyperlipoproteinemia, who received PCSK9 antibodies for the first time during routine care, were consecutively identified. 30817043 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE We recruited 49 nonfamilial hypercholesterolemia genetic hypercholesterolemia families (294 participants) and calculated cholesterol gene scores, derived from single nucleotide variants in SORT1, APOB, ABCG8, APOE and LDLR and lipoprotein(a) plasma concentration. 28919240 2018
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE The APOA-1M delivery method and therapeutic efficacy was tested in healthy mice and in Apoe<sup>-/-</sup> mice fed with high cholesterol diet (Western Diet, WD). 29907443 2018
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE Severe forms of mono- and polygenetic hypercholesterolemia as well as elevated Lipoprotein (a) (LP(a)) with progressing cardiovascular (CV) disease are indication for lipoprotein apheresis (LA) in Germany. 29096843 2017
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE However, due to new lipid lowering drug developments like PCSK9-inhibitors (PCSK-9-I) a therapeutic algorithm for patients with severe hypercholesterolemia or isolated Lipoprotein(a)-hyperlipoproteinemia with progressive cardiovascular disease may be necessary to manage the use of PCSK9-I, lipoprotein apheresis (LA) or both. 29096860 2017
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 AlteredExpression disease BEFREE During the 1970s, specific lipoprotein apheresis began to be used in high-risk patients with homozygous familial hypercholesterolemia, severe hypercholesterolemia and elevated Lipoprotein(a) levels and this review provides evidence of the effectiveness of the extracorporeal therapy with respect to the reduction of cardiovascular events. 29096824 2017
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Lipoprotein apheresis has been shown to improve the cardiovascular outcome in patients with atherosclerotic disease and therapy-refractory hypercholesterolemia or elevated lipoprotein (a) (Lp(a)). 29096838 2017
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials. 25614280 2015
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Phase 2 and 3 clinical trials in patients with moderate and severe hypercholesterolemia (including FH) show that this approach is safe and highly efficacious to lower LDL-C and lipoprotein(a). 25248569 2014
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 AlteredExpression disease BEFREE Total cholesterol, triglycerides, LDL cholesterol, Apo A, Apo B, AOPP, IMA, IL-6, and D-dimer concentrations were significantly higher in subjects with hypercholesterolemia. 23436135 2013
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 AlteredExpression disease BEFREE Lipoprotein apheresis is an efficient strategy to reduce the serum low-density lipoprotein (LDL)-cholesterol and lipoprotein(a) levels and cardiovascular complications in patients with severe hypercholesterolemia. 23357151 2013
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE In clinical trials, mipomersen produced dose-dependent and prolonged reductions in LDL-cholesterol and other apoB-containing lipoproteins, including lipoprotein (a) [Lp(a)] in healthy volunteers and in patients with mild to moderate hypercholesterolemia. 21210756 2011
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 AlteredExpression disease BEFREE At univariate analysis, hypertension, smoking, dyslipidaemia (both high cholesterol and triglyceride levels), antiphospholipid antibodies, hyperhomocysteinaemia, elevated factor VIII and lipoprotein(a) levels were significantly associated with retinal artery occlusion; at multivariate analysis, adjusted for age, sex, traditional and thrombophilic risk factors, smoking, hypercholesterolaemia, elevated homocysteine and lipoprotein(a) levels confirmed their independent role as risk factors for retinal artery occlusion. 17473572 2007
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease CTD_human Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia. 12697372 2003
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE To test the hypothesis that increased plasma levels of Lp(a) may enhance the development of atherosclerosis in the setting of hypercholesterolemia, we generated Watanabe heritable hyperlipidemic (WHHL) transgenic (Tg) rabbits expressing human apolipoprotein(a) (apo(a)). 12196525 2002
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 AlteredExpression disease BEFREE This effect was not due to an effect of irbesartan on lipoprotein levels because irbesartan slightly increased total cholesterol levels and decreased the ratio of Apo A-I relative to Apo B levels. 11486244 2001
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 Biomarker disease BEFREE Family history of early cardiovascular disease in children with moderate to severe hypercholesterolemia: relationship to lipoprotein (a) and low-density lipoprotein cholesterol levels. 10072255 1999
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.400 GeneticVariation disease BEFREE Therefore, we investigated Lp(a) concentrations and apolipoprotein(a) [apo(a)] polymorphism in 147 patients with hypertriglyceridemia and in 93 patients with hypercholesterolemia and compared them with 404 subjects without hyperlipoproteinemia (controls). 8177045 1994