Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
0.470 AlteredExpression disease BEFREE Together, these data suggest that milk cholesterol concentration in mice is not affected by conditions of maternal hypercholesterolaemia and is maintained at stable levels via ABCG8- and LDLR-independent mechanisms. 29891894 2018
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
0.470 Biomarker disease GENOMICS_ENGLAND Refinement of variant selection for the LDL cholesterol genetic risk score in the diagnosis of the polygenic form of clinical familial hypercholesterolemia and replication in samples from 6 countries. 25414277 2015
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
0.470 Biomarker disease BEFREE Harm caused by elevated cholesterol absorption rather than by plant sterols may therefore mediate the relationships of ABCG8 and ABO variants with CVD. 23707316 2013
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
0.470 GeneticVariation disease LHGDN Various polymorphisms (A632V, T400K, D19H, M429V, and C54Y) in the ABCG8 and ABCG5 (Q604E) gene have been found to be associated with several facets of cholesterol metabolism, including baseline cholesterol level, cholesterol kinetics, individual responsiveness of plasma cholesterol to dietary and pharmaceutical interventions for hypercholesterolemia, and increased risk of gallstones. 18522623 2008
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
0.470 GeneticVariation disease BEFREE Thus, the aim of the present study was to evaluate the possible association between the 1950C > G (ABCG5) and the 251A > G (ABCG8) polymorphisms and the presence of hypercholesterolemia (HC) in Chilean subjects. 19012522 2008
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
0.470 Biomarker disease BEFREE This review examines links between polymorphisms of ABC G5 (ABCG5) and G8 (ABCG8) transporter genes to hypercholesterolemia and to gallstone disease risk. 18522623 2008
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
0.470 GeneticVariation disease LHGDN These results suggest that the D19H polymorphism of ABCG8 could be considered a susceptible gene marker indicating an increased likelihood of developing high cholesterol and LDL-C levels in Taiwanese consuming an ordinary Chinese diet. 18581044 2008
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
0.470 GeneticVariation disease BEFREE These results suggest that the D19H polymorphism of ABCG8 could be considered a susceptible gene marker indicating an increased likelihood of developing high cholesterol and LDL-C levels in Taiwanese consuming an ordinary Chinese diet. 18581044 2008
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
0.470 AlteredExpression disease BEFREE These results demonstrate that increased expression of G5 and G8 attenuates diet-induced hypercholesterolemia in Ldlr-/- mice, resulting in a significant reduction in plasma levels of cholesterol and aortic atherosclerotic lesion area. 15175362 2004
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
0.470 GeneticVariation disease LHGDN These results suggest that, in patients with hypercholesterolemia, the ABCG8 D19H variant is associated with greater LDLC-lowering response to atorvastatin therapy. 14703505 2004
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8
0.470 Biomarker disease HPO