We found that <i>miR-200c</i> was up-regulated in FH compared with HS (4.00 ± 0.48-fold increase, <i>P</i><0.05) and exhibited a positive correlation with <i>miR-33a/b. miR-200c</i> did not correlate with plasma lipids, but correlated with C-reactive protein (CRP) plasma levels and glycaemia (GLI).
OLS (ordinary least squares) regression analysis revealed that miR-33a was significantly affected by the presence of FH (familial hypercholesterolaemia), glycaemia and CRP (P<0.001, P<0.05 and P<0.05 respectively).