Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Biomarker disease HPO
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 AlteredExpression disease BEFREE We hypothesized that proinsulin expression in peripheral blood mononuclear cells is a process relevant to this condition and could represent a link among hyperglycemia, nerve susceptibility, and diabetic foot lesions. 29436863 2018
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 GeneticVariation disease BEFREE We report a rare case of permanent neonatal diabetes (PND) due to insulin (INS) gene mutation in a 51-month-old girl who presented with hyperglycemia in the neonatal period. 23350652 2013
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 GeneticVariation disease CLINVAR INS-gene mutations: from genetics and beta cell biology to clinical disease. 25542748 2015
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Biomarker disease BEFREE Avoiding hyperglycemia in patients with EGI may be important for preventing excessive insulin demand indicated by disproportionately increased proinsulin secretion. 29885044 2018
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 GeneticVariation disease CLINVAR Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. 18192540 2008
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 GeneticVariation disease CLINVAR Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood. 18162506 2008
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Biomarker disease CTD_human Reversible impairment of renal function associated with enalapril in a diabetic patient. 9861226 1998
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Biomarker disease BEFREE The aim of this study was to conduct an in-depth analysis of pathological changes in retinas from INS <sup>C94Y</sup> pigs exposed to hyperglycaemia for more than 2 years, representing a chronic diabetic condition. 28480495 2017
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 AlteredExpression disease BEFREE Proinsulin levels correlated with glucose levels, suggesting that hyperglycemia is the main stimulus for increased proinsulin secretion. 7821172 1994
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 AlteredExpression disease BEFREE Expression of hProinsulin-B10 in the SMG of chemically induced diabetic mice prevented excessive hyperglycemia observed in untreated mice. 23554999 2013
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Biomarker disease BEFREE These findings indicate that elevated proinsulin and proinsulin/insulin ratios are secondary to increased demands on beta-cell secretion induced by hyperglycemia and insulin resistance with no discernible influence of family history of diabetes. 11978587 2002
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 GeneticVariation disease BEFREE In this report we present a family with permanent neonatal diabetes, heterozygous for a novel INS gene missense mutation, p.A24V, manifested with marked hyperglycemia and ketoacidosis, unstable glycemic control, requiring insulin therapy, rapid progression of long-term complications and accompanying physical pathological signs and brain lesions. 25765664 2015
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 AlteredExpression disease BEFREE In addition, SMIT1 expression in INS-1E cells and isolated islets was augmented by acute high-glucose exposure and reduced in chronic hyperglycemia conditions. 28202581 2017
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Therapeutic disease CTD_human Iatrogenic neonatal hypertrophic cardiomyopathy. 8660453 1996
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 AlteredExpression disease BEFREE Proinsulin levels remained within the normal range (suppressed with hypoglycemia) despite simultaneous almost unmeasurable C-peptide levels during hyperglycemia. 23337153 2014
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 GeneticVariation disease CLINVAR Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY). 20226046 2010
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Biomarker disease BEFREE Besides hyperglycemia, other factors contribute to the development of diabetic complications as the proinsulin connecting peptide, C-peptide. 29351386 2018
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 GeneticVariation disease BEFREE We hope to emphasize instead the homogeneity of nephropathy risk in both IDDM and NIDDM and also the idea that a common genetic susceptibility exists for all types of diabetes and is conditional on cumulative exposure to hyperglycemia. 9649955 1998
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Therapeutic disease CTD_human Reversible impairment of renal function associated with enalapril in a diabetic patient. 9861226 1998
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Biomarker disease BEFREE In every patient, fasting insulin, proinsulin, C-peptide and 1,5-anhydro-d-glucitol concentrations were assayed as markers of insulin secretion, peripheral resistance to insulin, and acute hyperglycaemia. 17207885 2007
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Biomarker disease CTD_mouse Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. 18056790 2008
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Biomarker disease CTD_human Iatrogenic neonatal hypertrophic cardiomyopathy. 8660453 1996
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Biomarker disease BEFREE Accumulation of misfolded proinsulin beyond a certain threshold begins to interfere with the normal intracellular transport of bystander proinsulin, leading to diminished insulin production and hyperglycemia, as well as exacerbating ER stress. 29377149 2018
Entrez Id: 3630
Gene Symbol: INS
INS
0.700 Biomarker disease BEFREE We report the correction of hyperglycemia of STZ induced diabetic mice using one intravenous systemic administration of a single stranded serotype 8 pseudotyped adeno-associated virus (ssAAV2/8) vector encoding the human proinsulin gene under a constitutive liver specific promoter. 26795016 2016