Gene: INSR ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.500 Biomarker disease BEFREE Insulin receptor (IR) insufficiency in β-cells leads to impaired insulin secretion and reduced β-cell hyperplasia in response to hyperglycemia. 29029025 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.500 Biomarker disease BEFREE Whether leflunomide can control hyperglycemia and sensitize the insulin receptor has not been tested. 29496905 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.500 GeneticVariation disease BEFREE Oral HP<i>β</i>CD/Ang-(1-7) treatment decreased <i>ACE</i> and <i>AT1R</i>, increased <i>ACE2</i> gene expression in the liver, and restored thiobarbituric acid reactive substances (TBARS), catalase (CAT), superoxide dismutase (SOD), insulin receptor substrate (<i>Irs-1</i>), glucose transporter type 4 (<i>GLUT4</i>), and serine/threonine kinase 2 (<i>AKT-2</i>) gene expression in the liver and gastrocnemius muscle improving hepatic function, cholesterol levels, and hyperglycemia in MetS rats. 31396301 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.500 Biomarker disease BEFREE Acute induction of insulin receptor knockout in adipocytes changed the substrate preference to fat before induction of a diabetic phenotype including hyperinsulinaemia and hyperglycaemia. 31309261 2019
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.500 Biomarker disease BEFREE Non-peptidyl small molecule, adenosine, 5'-Se-methyl-5'-seleno-, 2',3'-diacetate, activates insulin receptor and attenuates hyperglycemia in type 2 diabetic Lepr<sup>db/db</sup> mice. 31378829 2019