| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.260 | AlteredExpression | disease | BEFREE | Hyperglycemia (HG) affects cellular organelle including mitochondrion in retina that diminishes mitochondrial biogenesis by downregulation of nuclear transcription factors peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1α) and mitochondrial transcription factor A (TFAM). | 31529536 | 2019 | ||||
|
0.260 | Biomarker | disease | BEFREE | These results indicate that transcutaneous CO2 improves impaired muscle oxidative capacity via enhancement of eNOS and PGC-1α-related signaling in the skeletal muscle of rats with hyperglycemia. | 31184310 | 2019 | ||||
|
0.260 | Biomarker | disease | BEFREE | Prolonged exposure of BeWo cells to high glucose mimicking hyperglycemia resulted in decreased protein abundance of PGC-1α and its downstream factor, mitochondrial transcription factor A (TFAM). | 28433632 | 2017 | ||||
|
0.260 | AlteredExpression | disease | BEFREE | The unaltered PPARGC1A gene expression in muscle of O-T1D suggests that factors other than intrauterine hyperglycemia may contribute to the decreased PPARGC1A expression in O-GDM. | 27388218 | 2016 | ||||
|
0.260 | Biomarker | disease | BEFREE | Inhibition of PGC-1α or control of hyperglycemia may be beneficial in improving the efficacy of chemotherapy in MM patients with diabetes. | 25695395 | 2015 | ||||
|
0.260 | Biomarker | disease | RGD | Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis. | 22922125 | 2012 | ||||
|
0.260 | Biomarker | disease | RGD | Impact of hyperglycemic control on left ventricular myocardium. A molecular and cellular basic study in a diabetic rat model. | 19367030 | 2009 | ||||
|
0.260 | AlteredExpression | disease | BEFREE | These results suggest that metformin normalizes hyperglycemia-induced mtROS production by induction of MnSOD and promotion of mitochondrial biogenesis through the activation of AMPK-PGC-1alpha pathway. | 16380484 | 2006 |