Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE Aging (chronic age-related diseases); ii. metabolic (hyperglycemia advanced glycation end products and its receptor (AGE/RAGE) interactions and hyperinsulinemia-insulin resistance (a linking linchpin); iii. oxidative stress (reactive oxygen-nitrogen species); iv. inflammation (peripheral macrophage and central brain microglia); v. vascular (macrovascular accelerated atherosclerosis-vascular stiffening and microvascular NVU/neuroglial remodeling) with resulting impaired cerebral blood flow. 31569571 2019
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 AlteredExpression disease BEFREE Hyperglycemia increased the mRNA expression and protein levels of malondialdehyde (MDA), superoxide dismutase (SOD), monocyte chemoattractant protein‑1 (MCP‑1), intercellular adhesion molecule‑1 (ICAM‑1), fibronectin (FN), collagenase type 1 (COL‑1), HMGB1, RAGE and NF‑κB, and the effects could be reversed by dapagliflozin in a concentration‑dependent manner. 30132524 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE Sugar makes neutrophils RAGE: linking diabetes-associated hyperglycemia to thrombocytosis and platelet reactivity. 28504654 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE Advanced glycation end products generated by chronic hyperglycemia and their receptor RAGE provide critical links between diabetes and AD. 27156888 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE There is growing evidence that chronic hyperglycemia leads to the formation of advanced glycation end products (AGEs) which exerts its effect via interaction with the receptor for advanced glycation end products (RAGE). 28505121 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE Presently, we provide a translationally oriented review of key studies evaluating the aberrant effects of hyperglycemia on two major signaling pathways linked to debilitating cellular and systemic effects via targeted disruption of mitochondrial bioenergetics: (1) advanced glycation end-products (AGEs)/and their cognate receptor for advanced glycation end-products (RAGEs), and (2) the hexosamine biosynthetic pathway (HBP). 27084094 2016
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE Although the absence of RAGEs from birds has yet to be confirmed at the protein level, other differences between humans and birds may also be important in accounting for the ability of birds to live with chronic hyperglycemia. 24313337 2014
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 AlteredExpression disease BEFREE In conclusion, our study suggested that MET could reduce hyperglycemia-induced cardiocytes injury by inhibiting the expressions of RAGE and HMGB1. 24420848 2014
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE Our study is also the first to establish a distinct role of hyperglycemia and hypercholesterolemia in osteochondrogenic differentiation of SMCs and determined these cells as a major source contributing to cartilaginous and calcifying lesions of T2DM blood vessels, possibly mediated by RAGE. 22818582 2013
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease CTD_human Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia. 24036142 2013
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 AlteredExpression disease BEFREE Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands. 19833897 2010
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE Hyperglycaemia-induced pro-inflammatory responses by retinal Müller glia are regulated by the receptor for advanced glycation end-products (RAGE). 20835858 2010
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE The Receptor for Advanced Glycation End-products (RAGE) belongs to the family of pattern-recognition receptors and is significantly involved in the molecular mechanisms mediating pro-inflammatory action of hyperglycemia in diabetes. 20112183 2010
Entrez Id: 177
Gene Symbol: AGER
AGER
0.400 Biomarker disease BEFREE The RAGE binds multiple ligand families linked to hyperglycemia, aging, inflammation, neurodegeneration, and cancer. 19477910 2009