Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE At diagnosis of pediatric diabetes, absence of all islet autoantibodies and modest hyperglycemia (HbA<sub>1c</sub> <7.5% [58 mmol/mol]) should result in testing for GCK, HNF1A, and HNF4A MODY. 31704690 2020
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE This report describes GCK-MODY in a Chinese family and stresses that in managing this condition it is important to avoid unnecessary drug treatment and excessive anxiety about mild hyperglycemia. 31571622 2020
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 GeneticVariation disease BEFREE Identification and functional analysis of GCK gene mutations in 12 Chinese families with hyperglycemia. 30592380 2019
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE The GCK-MODY was identified by incidental hyperglycemia without glycosuria. 31216263 2019
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE We assessed the contribution of hyperglycemia by comparing insulin sensitivity in control and GCK-MODY and the contribution of hyperinsulinemia by comparing GCK-MODY and type 1 diabetes. 31092478 2019
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 AlteredExpression disease BEFREE Hyperglycemia markedly upregulated the expression of glycolytic enzymes (glucokinase and 6-phosphofructo-1-kinase, PFK1) 5 h following glucose administration, while at 24 h posttreatment, it increased isocitrate dehydrogenase (IDH) activity, a key enzyme of the tricarboxylic acid cycle, and the expression of lipogenic factors (PGC1β, Lpin1, and SREBP1). 30649892 2019
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE This case raises the question as to whether hyperglycaemia in GCK-MODY may increase the risk of fetal caudal regression syndrome as reported in women with pre-existing diabetes mellitus. 30362177 2019
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE In conclusion, this novel GCK mutant rabbit generated with the CRISPR/Cas9 system mimics most, if not all, histopathological and functional defects seen in MODY-2 patients such as hyperglycemia and will be a valuable rabbit model for preclinical studies and drug screening for diabetes as well as for studying the pathophysiological role of glucokinase. 31720743 2019
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 GeneticVariation disease BEFREE Computational analyses to investigate pathogenicity and molecular dynamics (MD) were performed for GCK-E372D and for previously described homozygous mutations associated with mild (n = 2) or severe (n = 1) hyperglycemia, used as references. 31197960 2019
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE GCK-MODY is characterized by mild hyperglycemia. 30535721 2019
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE The study presented a simpler and more reliable way in studying the properties of glucokinase and its effectors, providing guidelines of effector developments for hyperglycemia and hypoglycemia treatment. 31011989 2019
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE The clinical characteristics of patients with GK-activating mutations or GK regulatory protein (GKRP) loss-of-function mutations suggest that a hepatoselective GK activator (GKA) that does not activate GK in β cells or affect the GK-GKRP interaction may reduce hyperglycemia in patients with type 2 diabetes while limiting hypoglycemia and liver-associated adverse effects. 30651321 2019
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE Heterozygous inactivating mutations in the GCK gene cause the familial, mild fasting hyperglycaemia named MODY2. 29704611 2018
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 AlteredExpression disease BEFREE We hypothesize that not all MODY 2 affected fetuses need the same levels of hyperglycemia to have an appropriate growth, maybe because different kinds of GCK mutations may result in different phenotypes. 30105470 2018
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 GeneticVariation disease BEFREE However, the effect of naturally occurring GCK mutations on the pathogenesis for MODY2 hyperglycaemia remains largely unclear, especially in the Asian population. 30257192 2018
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE Eleven children with asymptomatic hyperglycemia and clinically suspected GCK-MODY were identified from the database of children with diabetes in the biggest children's hospital in South China. 29510678 2018
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE The findings leading to the diagnosis were impaired fasting glucose (IFG) (15/37), symptoms of hyperglycemia (4/37), and a GCK-MODY family history (18/37). 28663157 2017
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 AlteredExpression disease BEFREE We developed a gene therapy approach to control diabetic hyperglycemia based on co-expression of the insulin and glucokinase genes in skeletal muscle. 28626777 2017
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE GCK-MODY leads to mildly elevated blood glucose typically not requiring therapy. 27106716 2016
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 CausalMutation disease CLINVAR Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes. 27271189 2016
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE Maturity-onset diabetes of the young 2 (MODY2) is a form of diabetes that is clinically characterized by early age at onset and mild hyperglycemia, and has a low risk of late complications. 27289208 2016
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 GeneticVariation disease BEFREE Inactivating heterozygous mutations in the GCK gene are a common cause of MODY and result in mild fasting hyperglycaemia, which does not require treatment. 27256595 2016
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 AlteredExpression disease BEFREE Glucokinase is inhibited in the postabsorptive state by sequestration in the nucleus bound to GKRP, and it is activated postprandially by portal hyperglycemia and fructose through dissociation from GKRP, translocation to the cytoplasm, and binding to PFK2/FBP2. 27146014 2016
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 GeneticVariation disease BEFREE The principal objective of the current study is to determine the outcomes and clinical management of hyperglycemia in pregnancies complicated by glucokinase gene (GCK) and hepatocyte nuclear factor (HNF)-1α MODY mutations. 25935773 2015
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.500 Biomarker disease BEFREE GCK-MODY patients are typically characterized by a moderate fasting hyperglycemia; however, little is known about atherosclerosis and intermediate-related phenotypes in these subjects. 25501962 2015