Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE HG (30 mM) exposed PC12 cells demonstrated reduced mitochondrial complex activities and oxygen consumption rate (OCR), decreased the expressions of Sirt1, peroxisome proliferator-activated receptor coactivator-1α (PGC1α), nuclear respiratory factor-2 (NRF2), LONP1 and ATP synthase c. SRT1720 treatment (4 μM) significantly reversed these effects in hyperglycemia insulted PC12 cells but silencing the expression of LONP1 impeded this effect of SRT1720 on mitochondrial complex activities, OCR and mitochondrial membrane potential. 31639451 2020
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE <i>In vitro</i> experiments in rat macrophages showed that hyperglycemia treatment suppresses Nrf2 activation, resulting in oxidative stress with decreased expression of antioxidant genes, including NAD(P)H:quinone oxidoreductase 1 and heme oxygenase 1, together with increased secretion of proinflammatory cytokines, including interleukin 1β (IL1β), IL6, and monocyte chemoattractant protein-1. 31616304 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 AlteredExpression disease BEFREE Hyperglycemia also modulated both gene expression and nuclear translocation of the redox-sensitive transcription factor Nrf2. 30359759 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 AlteredExpression disease BEFREE Pharmacologic or systemic genetic activation of the Nrf2 pathway partially protects from obesity in mice and ameliorates fasting hyperglycemia in mice and humans. 29486138 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE Taken together, the endothelial protective effect of Baicalin under hyperglycemia condition could be partly attributed to its role in downregulating reactive oxygen species (ROS) and inflammation via the Akt/GSK3B/Fyn-mediated Nrf2 activation. 30400057 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE HX-1171 attenuates pancreatic β-cell apoptosis and hyperglycemia-mediated oxidative stress via Nrf2 activation in streptozotocin-induced diabetic model. 29849938 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 AlteredExpression disease BEFREE Cellular experiments indicate that Nrf2 expression inhibits hyperglycemia-induced apoptosis and promotes angiogenesis by regulating the TLR4/NFκB signal pathway. 29719281 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE Further, Andro blocked hyperglycemia-triggered reactive oxygen species (ROS) generation by suppressing NADPH oxidase (NOX) activation and augmenting nuclear factor erythroid 2-related factor 2 (Nrf2) expression both <i>in vitro</i> and <i>in vivo</i>. 30046380 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 AlteredExpression disease BEFREE In conclusion, PPAR<i>β</i>/<i>δ</i> activation confers vascular protection against hyperglycemia-induced oxidative stress by suppressing NOX-2 and NOX-4 expression plus a direct induction of HO-1; with the subsequent downregulation of the Nrf2 pathway. 30046379 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE <b>Conclusion:</b> The results of our study show the hypoglycemic impact of black truffle on STZ-induced hyperglycemia in rats via Nrf2 and NF-κB pathways, and both pathways have significant improvement that may support the hypoglycemic impact of truffle. 30473664 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 AlteredExpression disease BEFREE Gene knockdown of PHLPP1 in NRK52E cells enhanced Nrf2-responsive antioxidant enzymes HO-1 and NQO-1 which suggested that PHLPP1 up-regulation during hyperglycemia lowers Nrf2 stability via GSK3β activation. 29655866 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 GeneticVariation disease BEFREE In this study, HepG2 cells have been used to investigate the toxic effects of hyperglycemia and/or quercetin (Q) on mammalian target of rapamycin (m-TOR) and nuclear factor erythroid 2-related factor 2 (Nrf-2) expression as central molecules involved in cancer. 29781726 2018
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity. 28040599 2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 AlteredExpression disease BEFREE Acute hyperglycemia increases the expression of Nrf2, but persistent hyperglycemia decreases its expression. 28353124 2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway. 28254022 2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 AlteredExpression disease BEFREE These results indicate that ASP maintains cellular homeostasis and protects the myocardium against hyperglycemia-induced oxidative stress through activation of <i>Nrf2</i> and its downstream target genes. 28098811 2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE Effects of C-Glycosides from Apios americana Leaves against Oxidative Stress during Hyperglycemia through Regulating Mitogen-Activated Protein Kinases and Nuclear Factor Erythroid 2-Related Factor 2. 28758742 2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 AlteredExpression disease BEFREE Nrf2/ARE signaling pathway is a crucial cellular defense system to cope with oxidative stress, which is adaptively activated, in diabetic condition that is not efficient enough to resist the oxidative stress provoked by hyperglycemia. 27840317 2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE Taken together, the data suggest that Nrf2-modulated antioxidant stress plays a crucial role in maternal hyperglycaemia-induced neurodevelopmental defects. 27497668 2016
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 PosttranslationalModification disease BEFREE The effect of hyperglycemia on H3K4 methylation in Nrf2 binding at Gclc-ARE4 was investigated by chromatin immunoprecipitation in the rat retina and was confirmed in retinal endothelial cells in which histone demethylase (LSD1) was manipulated. 25016074 2014
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease BEFREE We hypothesized that hyperglycemia will lead to a dysfunction of the Nrf2-dependent antioxidative protection in the lens of diabetics. 22683333 2012
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 Biomarker disease CTD_human Compared with wild-type mice, mice lacking Nrf2 (Nrf2-null) have lower basal serum insulin and prolonged hyperglycemia in response to an intraperitoneal glucose challenge. 20086057 2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.400 AlteredExpression disease BEFREE The aim of this study was to assess whether activation of nrf2 by sulforaphane in human microvascular endothelial cells prevents metabolic dysfunction in hyperglycemia. 18633117 2008