Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 AlteredExpression disease BEFREE In addition, correlations between urinary monocyte chemoattractant protein-1 and glycemic and inflammatory marker levels revealed the role of hyperglycemia and chronic inflammation in the pathogenesis of diabetic kidney disease. 31250339 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 AlteredExpression disease BEFREE The intervention also suppressed serum monocyte chemotactic protein-1 and interleukin-6 levels, which are proinflammatory cytokines involved in the development of insulin resistance and hyperglycemia. 30502681 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 AlteredExpression disease BEFREE <i>In vitro</i> experiments in rat macrophages showed that hyperglycemia treatment suppresses Nrf2 activation, resulting in oxidative stress with decreased expression of antioxidant genes, including NAD(P)H:quinone oxidoreductase 1 and heme oxygenase 1, together with increased secretion of proinflammatory cytokines, including interleukin 1β (IL1β), IL6, and monocyte chemoattractant protein-1. 31616304 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 AlteredExpression disease BEFREE Following hyperglycemia, retinal pigmented epithelial (RPE) cells, endothelial cells, and Müller's glial cells are of utmost importance for MCP-1 production, and vitreous MCP-1 levels rise in patients with DR. 30607767 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 AlteredExpression disease BEFREE Hyperglycemia induces NF-κB activation and MCP-1 expression via downregulating GLP-1R expression in rat mesangial cells: inhibition by metformin. 31136032 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker disease BEFREE PubMed, Scopus, Embase, ProQuest and Google Scholar databases were searched to fined interventional studies from the effects of chromium on inflammatory biomarkers such as tumour necrosis factor a (TNF-a), C-reactive protein (CRP), interleukins, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1) and adipocytokines in hyperglycaemia and diabetes. 31330062 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 AlteredExpression disease BEFREE Stress hyperglycemia and diabetes may contribute to high monocyte chemoattractant protein-1 levels and prolonged inflammation. 30988769 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 AlteredExpression disease BEFREE Canagliflozin attenuates the progression of atherosclerosis, reducing (1) hyperlipidemia and hyperglycemia, and (2) inflammatory process, by lowering the expression of inflammatory molecules such as MCP-1 and VCAM-1. 30049285 2018
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 AlteredExpression disease BEFREE Hyperglycemia increased the mRNA expression and protein levels of malondialdehyde (MDA), superoxide dismutase (SOD), monocyte chemoattractant protein‑1 (MCP‑1), intercellular adhesion molecule‑1 (ICAM‑1), fibronectin (FN), collagenase type 1 (COL‑1), HMGB1, RAGE and NF‑κB, and the effects could be reversed by dapagliflozin in a concentration‑dependent manner. 30132524 2018
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker disease BEFREE The rapid decrease of blood creatinine, urine creatinine, and blood urea nitrogen suggested that the recovery of renal functions compromised by hyperglycemia could also be attributed to MCP-1. 24600221 2014
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 Biomarker disease BEFREE Hyperglycemia induces MCP-1 production in vascular endothelial cells and retinal pigmented epithelial cells, and has been implicated as a causal factor in the facilitation of vascular complications in diabetes. 23549806 2013
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.400 AlteredExpression disease BEFREE Experimental evidence indicates that previous hyperglycemia is associated with persistent expression of the NFκB p65 gene, which activates NFκB-dependent proteins, such as MCP-1, which are implicated in diabetes-associated vascular injury. 20599797 2010