Gene: UCP2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7351
Gene Symbol: UCP2
UCP2 		0.370 GeneticVariation disease BEFREE Mutation analysis was carried out for 8 genes associated with HI (ABCC8, KCNJ11, GLUD1, GCK, HADH, HNF4A, HNF1A, and UCP2). 29493090 2018
Entrez Id: 7351
Gene Symbol: UCP2
UCP2 		0.370 AlteredExpression disease BEFREE VSMCs subjected to hyperinsulinemia exhibited increased migration and proliferation, and this is paralleled by oxidative stress [increased NADPH oxidase activity, NADPH oxidase 1 mRNA expression, and reactive oxygen species (ROS) generation], alterations in mitochondrial physiology (membrane depolarization, decreased mitochondrial mass, and increased mitochondrial ROS), changes in mitochondrial biogenesis-related genes (mitofusin 1, mitofusin 2, dynamin-related protein 1, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, peroxisome proliferator-activated receptor gamma coactivator 1-beta, nuclear respiratory factor 1, and uncoupling protein 2), and increased Akt phosphorylation. 23073711 2013
Entrez Id: 7351
Gene Symbol: UCP2
UCP2 		0.370 GeneticVariation disease BEFREE In conclusion, our results suggest that the -866 AA genotype and A allele of the UCP2 gene is associated with obesity and A allele associated with hyperinsulinemia in obese subjects. 19908126 2010
Entrez Id: 7351
Gene Symbol: UCP2
UCP2 		0.370 Biomarker disease GENOMICS_ENGLAND Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion. 19065272 2008
Entrez Id: 7351
Gene Symbol: UCP2
UCP2 		0.370 AlteredExpression disease BEFREE Conversely, lowering UCP2 expression may promote increased insulin secretion. 17052202 2006
Entrez Id: 7351
Gene Symbol: UCP2
UCP2 		0.370 Biomarker disease BEFREE From the three different human UCPs identified so far by gene cloning both UCP2 and UCP3 were mapped in close proximity (75-150 kb) to regions of human chromosome 11 (11q13) that have been linked to obesity and hyperinsulinaemia. 10027754 1999
Entrez Id: 7351
Gene Symbol: UCP2
UCP2 		0.370 Biomarker disease BEFREE The murine UCP2 was mapped to a region on mouse chromosome 7 which in several models has been shown to be linked to obesity and hyperinsulinaemia. 9349606 1997
Entrez Id: 7351
Gene Symbol: UCP2
UCP2 		0.370 Biomarker disease BEFREE Finally, UCP2 maps to regions of human chromosome 11 and mouse chromosome 7 that have been linked to hyperinsulinaemia and obesity. 9054939 1997