Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1758
Gene Symbol: DMP1
DMP1
0.010 AlteredExpression disease BEFREE Nevertheless, it remains unknown whether attenuated DMP1 affects FGF23 expression in hyperparathyroidism. 30916761 2019
Entrez Id: 10407
Gene Symbol: SPAG11B
SPAG11B
0.010 Biomarker disease BEFREE Furthermore, PGE2 or EP2 agonist (butaprost) directly stimulated hyperparathyroidism, whereas EP2 receptor antagonist or cyclic adenosine monophosphate inhibitor attenuated the hyperparathyroidism promoted by PGE2 or butaprost. 29982796 2019
Entrez Id: 8490
Gene Symbol: RGS5
RGS5
0.010 AlteredExpression disease BEFREE Parathyroid-Targeted Overexpression of Regulator of G-Protein Signaling 5 (RGS5) Causes Hyperparathyroidism in Transgenic Mice. 30690792 2019
Entrez Id: 5111
Gene Symbol: PCNA
PCNA
0.010 AlteredExpression disease BEFREE In primary cultured PTG tissues, HPi induced intact parathyroid hormone (iPTH) secretion, proliferating cell nuclear antigen (PCNA) expression and COX2 activity, while COX2 and EP2 inhibitors attenuated hyperparathyroidism promoted by HPi. 29982796 2019
Entrez Id: 50964
Gene Symbol: SOST
SOST
0.010 AlteredExpression disease BEFREE CKD-MBD is a complex disease condition in which sclerostin antibodies may interfere at different levels and influence the multiform interplay of hyperparathyroidism, renal osteodystrophy and vascular calcification, but the clinical sequelae remain obscure. 29846712 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.010 AlteredExpression disease BEFREE In primary cultured PTG tissues, HPi induced intact parathyroid hormone (iPTH) secretion, proliferating cell nuclear antigen (PCNA) expression and COX2 activity, while COX2 and EP2 inhibitors attenuated hyperparathyroidism promoted by HPi. 29982796 2019
Entrez Id: 2235
Gene Symbol: FECH
FECH
0.010 Biomarker disease BEFREE A comprehensive computer literature search of PubMed/MEDLINE, EMBASE and Cochrane Library databases for studies published through May 2018 was performed using the following search algorithm: (a) "choline" or "fluorocholine" or "F-choline" or "C-choline" or "FCH" or "CH" or "FECH" or "FMCH" and (b) "PET" or "positron emission tomography" and (c) "parathyroid" or "hyperparathyroidism". 30094461 2019
Entrez Id: 653423
Gene Symbol: SPAG11A
SPAG11A
0.010 Biomarker disease BEFREE Furthermore, PGE2 or EP2 agonist (butaprost) directly stimulated hyperparathyroidism, whereas EP2 receptor antagonist or cyclic adenosine monophosphate inhibitor attenuated the hyperparathyroidism promoted by PGE2 or butaprost. 29982796 2019
Entrez Id: 5732
Gene Symbol: PTGER2
PTGER2
0.010 Biomarker disease BEFREE Furthermore, PGE2 or EP2 agonist (butaprost) directly stimulated hyperparathyroidism, whereas EP2 receptor antagonist or cyclic adenosine monophosphate inhibitor attenuated the hyperparathyroidism promoted by PGE2 or butaprost. 29982796 2019
Entrez Id: 223117
Gene Symbol: SEMA3D
SEMA3D
0.010 Biomarker disease BEFREE We propose that because Sema3d is a secreted protein, it may be possible to use recombinant Sema3d or derived peptides to inhibit parathyroid cell proliferation causing hyperplasia and hyperparathyroidism. 30979723 2019
Entrez Id: 23590
Gene Symbol: PDSS1
PDSS1
0.010 Biomarker disease BEFREE Compared with SPS, CPS may be safer for the treatment of hyperkalemia in pre-dialysis patients, because it did not induce hyperparathyroidism or volume overload. 28421299 2018
Entrez Id: 6943
Gene Symbol: TCF21
TCF21
0.010 Biomarker disease BEFREE Normal parathyroid metabolism was documented in 139 (32.7%) patients on POD 1 and in 423 (99.5%) 6 months postoperatively, while 2 (0.5%) patients had persistent hyperparathyroidism, one diagnosed between POD 5 and 7 and another at POW 8. 28906021 2018
Entrez Id: 79585
Gene Symbol: CORO7
CORO7
0.010 Biomarker disease BEFREE Normal parathyroid metabolism was documented in 139 (32.7%) patients on POD 1 and in 423 (99.5%) 6 months postoperatively, while 2 (0.5%) patients had persistent hyperparathyroidism, one diagnosed between POD 5 and 7 and another at POW 8. 28906021 2018
Entrez Id: 9496
Gene Symbol: TBX4
TBX4
0.010 Biomarker disease BEFREE Compared with SPS, CPS may be safer for the treatment of hyperkalemia in pre-dialysis patients, because it did not induce hyperparathyroidism or volume overload. 28421299 2018
Entrez Id: 22929
Gene Symbol: SEPHS1
SEPHS1
0.010 Biomarker disease BEFREE Compared with SPS, CPS may be safer for the treatment of hyperkalemia in pre-dialysis patients, because it did not induce hyperparathyroidism or volume overload. 28421299 2018
Entrez Id: 6611
Gene Symbol: SMS
SMS
0.010 Biomarker disease BEFREE Compared with SPS, CPS may be safer for the treatment of hyperkalemia in pre-dialysis patients, because it did not induce hyperparathyroidism or volume overload. 28421299 2018
Entrez Id: 27306
Gene Symbol: HPGDS
HPGDS
0.010 AlteredExpression disease BEFREE The aim of this study was to further elucidate the mechanisms of dual-phase technetium-99m methoxyisobutylisonitrile (Tc-MIBI) parathyroid imaging by exploring the association between early uptake results (EUR), delayed uptake results (DUR), and the retention index (RI) in dual-phase Tc-MIBI parathyroid imaging and P glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), and glutathione S-transferase-π (GST-π) expression in hyperparathyroidism (HPT). 28806349 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.010 Biomarker disease BEFREE As P-gp and GST-π expressions were higher in tissues resected from control compared with HPT patients, Tc-MIBI may wash out faster from normal parathyroid tissue surrounding the lesion compared with the lesion itself, facilitating detection. 28806349 2017
Entrez Id: 4194
Gene Symbol: MDM4
MDM4
0.010 Biomarker disease BEFREE Dual-phase 99mTc-MIBI imaging and the expressions of P-gp, GST-π, and MRP1 in hyperparathyroidism. 28806349 2017
Entrez Id: 6557
Gene Symbol: SLC12A1
SLC12A1
0.010 GeneticVariation disease BEFREE We describe 4 patients with 4 novel mutation variants in the SLC12A1 gene (c.735C>G, c.1137del, c.2498-2499del, and c.1833delT) presenting with variable degrees of hyperparathyroidism, hypercalcemia, hypokalemic metabolic alkalosis, nephrocalcinosis, and nephrogenic diabetes insipidus. 28095294 2017
Entrez Id: 4437
Gene Symbol: MSH3
MSH3
0.010 Biomarker disease BEFREE Dual-phase 99mTc-MIBI imaging and the expressions of P-gp, GST-π, and MRP1 in hyperparathyroidism. 28806349 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.010 Biomarker disease BEFREE T cell-produced TNF and IL-17A further contribute to bone loss in hyperparathyroidism, while T cell production of the anabolic Wingless integration site (Wnt) ligand, Wnt10b, promotes bone formation in response to anabolic parathyroid hormone and the immunomodulatory costimulation inhibitor cytotoxic T lymphocyte-associated protein-4-IgG (abatacept). 29046115 2017
Entrez Id: 7480
Gene Symbol: WNT10B
WNT10B
0.010 Biomarker disease BEFREE T cell-produced TNF and IL-17A further contribute to bone loss in hyperparathyroidism, while T cell production of the anabolic Wingless integration site (Wnt) ligand, Wnt10b, promotes bone formation in response to anabolic parathyroid hormone and the immunomodulatory costimulation inhibitor cytotoxic T lymphocyte-associated protein-4-IgG (abatacept). 29046115 2017
Entrez Id: 407014
Gene Symbol: MIR25
MIR25
0.010 AlteredExpression disease BEFREE We identified parathyroid miRNAs that were dysregulated in experimental hyperparathyroidism, including miR-29, miR-21, miR-148, miR-30, and miR-141 (upregulated); and miR-10, miR-125, and miR-25 (downregulated). 28298326 2017
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.010 Biomarker disease BEFREE P-gp, MRP1, and GST-π expressions were assessed using immunohistochemistry in resected tissue from HPT and control patients. 28806349 2017