Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26986
Gene Symbol: PABPC1
PABPC1
0.010 Biomarker group BEFREE Moreover, this study focused on the function of lncRNA NONRATT011842 in the vascular smooth muscle cells (VSMCs) during hypertension and confirmed that NONRATT011842 could interact with PABPC1 to regulate the functions of VSMCs. 31743794 2020
Entrez Id: 374291
Gene Symbol: NDUFS7
NDUFS7
0.010 GeneticVariation group BEFREE In KPNC, the hypertension PAR% was 40% (95% CI 18-62%) and 23% (95% CI 2-44%) among black women and men, and 27% (95% CI 20-35%) and 19% (95% CI 14-24%) among white women and men, respectively. 31782041 2020
Entrez Id: 6272
Gene Symbol: SORT1
SORT1
0.010 Biomarker group BEFREE A machine-learning approach confirmed GDF-15, LEP and SORT-1 as discriminant biomarkers for the hypertension group, and LEP plus PRELP for the obesity group. 31062082 2020
Entrez Id: 4489
Gene Symbol: MT1A
MT1A
0.010 GeneticVariation group BEFREE Combined effect of NQO1-rs1800566, HMOX1-rs2071746, and MT1A-rs11640851 was evaluated on the risks of DM and hypertension. 31332605 2020
Entrez Id: 9068
Gene Symbol: ANGPTL1
ANGPTL1
0.010 Biomarker group BEFREE Targeting Ang III by inhibiting brain APA is now considered a potentially important target in the management of hypertension. 31786978 2020
Entrez Id: 100526830
Gene Symbol: SLX1A-SULT1A3
SLX1A-SULT1A3
0.010 Biomarker group BEFREE In conclusion, STM could reverse the hypertension and left ventricular remolding caused by abdominal aortic constriction in rats. 31415848 2020
Entrez Id: 445329
Gene Symbol: SULT1A4
SULT1A4
0.010 Biomarker group BEFREE In conclusion, STM could reverse the hypertension and left ventricular remolding caused by abdominal aortic constriction in rats. 31415848 2020
Entrez Id: 389840
Gene Symbol: MAP3K15
MAP3K15
0.010 Biomarker group BEFREE By contrast MAP3K15 (ASK3) may protect from hypertension and BRAF inhibitors in clinical use may induced acute kidney injury and nephrotic syndrome. 31196660 2020
Entrez Id: 406984
Gene Symbol: MIR200B
MIR200B
0.010 Biomarker group BEFREE Involvement of miR-200b-PKCα signalling in pulmonary hypertension in cor pulmonale model. 31730233 2020
Entrez Id: 3261
Gene Symbol: HPV18I2
HPV18I2
0.010 AlteredExpression group BEFREE The area under the ROC curve of Lp-PAL2 levels in the H-type hypertension group was 0.665 (95% CI: 0.561-0.768, P = .004). 31630457 2020
Entrez Id: 51526
Gene Symbol: OSER1
OSER1
0.010 Biomarker group BEFREE Association of OSR-1 With Vascular Dysfunction and Hypertension in Polycystic Kidney Disease. 31020807 2020
Entrez Id: 147495
Gene Symbol: APCDD1
APCDD1
0.010 Biomarker group BEFREE Hypertonic saline (23.4%, HTS) bolus administration is common practice for refractory intracranial hypertension, but its effects on coagulation are unknown. 31843691 2020
Entrez Id: 55213
Gene Symbol: RCBTB1
RCBTB1
0.010 GeneticVariation group BEFREE In multivariate analysis, sex, disease duration, HbA1c, micro and macroangiopathy, insulin therapy and hypertension remained strongly associated with severe DR, while no association was found with GLP-1RA exposure (OR1.139 [0.800-1.622], p=0.47). 31589290 2020
Entrez Id: 51378
Gene Symbol: ANGPT4
ANGPT4
0.010 Biomarker group BEFREE Targeting Ang III by inhibiting brain APA is now considered a potentially important target in the management of hypertension. 31786978 2020
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.010 Biomarker group BEFREE By contrast MAP3K15 (ASK3) may protect from hypertension and BRAF inhibitors in clinical use may induced acute kidney injury and nephrotic syndrome. 31196660 2020
Entrez Id: 3320
Gene Symbol: HSP90AA1
HSP90AA1
0.010 Biomarker group BEFREE Our study suggests that calcineurin/Drp1-dependent mitochondrial fission may be essential for understanding adventitial remodeling in hypertension and that HSP90 inhibition may serve as a novel approach for the treatment of adventitial remodeling-related diseases. 31346611 2020
Entrez Id: 8540
Gene Symbol: AGPS
AGPS
0.010 GeneticVariation group BEFREE The bigger volumes of WMHs correlated with worse performances on ADAS-Cog13 and ADNI-EF (p = 0.029; p = 0.003) at baseline and MMSE, MoCA, CDRSB, ADAS-Cog13, FAQ, and ADNI-Mem (overall p < 0.05) longitudinally, after adjusting for age, sex, educational level, apolipoprotein E ɛ4 genotype, hypertension, hyperlipidemia, diabetes, smoking, infarction, and diagnosis. 31839612 2020
Entrez Id: 79001
Gene Symbol: VKORC1
VKORC1
0.010 GeneticVariation group BEFREE Multivariate analysis on the derivation cohort (n = 104) showed that a dosing model consisting of hypertension (HTN), heart failure (HF), VKORC1 (-1639G>A), CYP2C9*2 & *3, and smoking could explain 39.2% of warfarin dose variability in Qataris (P < 0.001). 31653973 2020
Entrez Id: 6818
Gene Symbol: SULT1A3
SULT1A3
0.010 Biomarker group BEFREE In conclusion, STM could reverse the hypertension and left ventricular remolding caused by abdominal aortic constriction in rats. 31415848 2020
Entrez Id: 4724
Gene Symbol: NDUFS4
NDUFS4
0.010 Biomarker group BEFREE In KPNC, the hypertension PAR% was 40% (95% CI 18-62%) and 23% (95% CI 2-44%) among black women and men, and 27% (95% CI 20-35%) and 19% (95% CI 14-24%) among white women and men, respectively. 31782041 2020
Entrez Id: 342096
Gene Symbol: GOLGA6A
GOLGA6A
0.010 GeneticVariation group BEFREE In multivariate analysis, sex, disease duration, HbA1c, micro and macroangiopathy, insulin therapy and hypertension remained strongly associated with severe DR, while no association was found with GLP-1RA exposure (OR1.139 [0.800-1.622], p=0.47). 31589290 2020
Entrez Id: 2516
Gene Symbol: NR5A1
NR5A1
0.010 Biomarker group BEFREE When administered in a rat model of placental ischemia, SynB1-ELP-p50i partially ameliorated placental ischemia-induced hypertension and reduced placental TNF-α levels with no signs of toxicity. 31786977 2020
Entrez Id: 3687
Gene Symbol: ITGAX
ITGAX
0.010 Biomarker group BEFREE Utilizing our genetic mouse model of inducible renal lymphangiogenesis, we demonstrated that greatly augmenting renal lymphatic density prior to angiotensin II infusion prevented the development of hypertension in male and female mice and this was associated with a reduction in renal CD11c+F4/80- monocytes. 31429865 2020
Entrez Id: 479
Gene Symbol: ATP12A
ATP12A
0.010 Biomarker group BEFREE Since magnesium is a potent vasodilator, which modulates vasomotor tone, peripheral blood flow, and hypertension, its deficiency could have significant cardiovascular and blood pressure (BP) effects.<b>Areas covered</b>: Studies have shown that several factors can contribute to magnesium deficiency including age, diet, disease, and certain drugs such as diuretics and proton-pump inhibitors (PPIs). 31795777 2020
Entrez Id: 495
Gene Symbol: ATP4A
ATP4A
0.010 Biomarker group BEFREE Since magnesium is a potent vasodilator, which modulates vasomotor tone, peripheral blood flow, and hypertension, its deficiency could have significant cardiovascular and blood pressure (BP) effects.<b>Areas covered</b>: Studies have shown that several factors can contribute to magnesium deficiency including age, diet, disease, and certain drugs such as diuretics and proton-pump inhibitors (PPIs). 31795777 2020