Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensin-converting enzyme (ACE) inhibitors have been acknowledged as first-line agents for the treatment of hypertension and a variety of cardiovascular disorders. 30058413 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Using ERPs, potential cognitive decline was linked to ACE genotypes, independently of the effect of hypertension. 25743267 2015
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE The ACE D allele is known to increase the risk of malignant ventricular arrhythmias and is also associated with increased QT dispersion after myocardial infarction and hypertension. 28575882 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Unlike the defined role of angiotensin-converting enzyme (ACE) gene in adult hypertension, ACE gene did not show direct influence on childhood blood pressure (BP), rather, seemed to be related to childhood growth with age-dependent characteristics. 22082670 2012
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 AlteredExpression group BEFREE In addition, our data also indicate that plasma ACE activity (adjusted OR was 1.13(95% CI: 1.08-1.18)) was significantly related to hypertension. 24098401 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE The HF-diet-induced increase of ACE serum concentrations reveals ACE to be a potential molecular link between dietary fat intake and hypertension and cardiovascular disease (CVD). 28096099 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE 5A5A and 5A6A genotypes of MMP-3 (odds ratio (OR) 1.5; P = 0.021), II and ID genotypes of ACE (OR 1.7; P = 0.006) along with traditional ischaemic heart disease risk factors such as smoking (OR 4.9; P = 0.001), hypertension (OR 2.0; P = 0.001), diabetes mellitus (OR 2.9; P = 0.001) and dyslipidaemia (OR 2.1; P = 0.001) increased the risk of STEMI. 29141503 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE We hypothesized that perindopril, an angiotensin-converting enzyme (ACE) inhibitor, indicated for the treatment of hypertension (Ceconi et al., in Cardiovasc Res 73:237-246, 2007), and which plays a role in preventing endothelial dysfunction, may help to prevent or reduce the severity of regorafenib-induced HFSR. 30535909 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE We observed no significant increase in the risk of hypertension for either African Americans or Latinos homozygous or heterozygous for the D allele of the ACE gene. 15545843 2004
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE He also presented with hypertension and genetic testing revealed that she had the high blood pressure D variant of the ACE gene in a heterozygous state, which moderately predisposes to hypertension. 30804141 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Three-drug combinations: ACE inhibitor + beta-blocker + calcium antagonist, for patients with hypertension and coronary artery disease requiring intensive therapy, and ACE inhibitor + beta-blocker + statin, which will enable SPCs therapy for most patients, would also be useful. 29251761 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensinogen was selected because of the putative link between it and mild to moderate essential hypertension and nephrosclerosis; angiotensin-converting enzyme because of its possible contribution to diabetic nephropathy; and renin, the angiotensin II receptor, and kallikrein because of their roles in hypertension and renal perfusion. 8989734 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Antagonists of the renin-angiotensin system, such as angiotensin type 1 (AT(1)) receptor inhibitors and angiotensin-converting enzyme inhibitors, are becoming increasingly popular agents in treating patients with systemic hypertension and minimizing organ damage. 11897210 2002
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE I/D ACE and ADRA2B polymorphisms were associated with AH. 29027816 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE The genes encoding for the angiotensin-converting enzyme, endothelial constitutive nitric oxide synthase, and cytochrome P450 3A isoenzyme have been involved in the development of hypertension and in calcineurin inhibitor-induced hypertension. 20099993 2010
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE The I/D polymorphism of the ACE gene is not a marker for either form of hypertension in this large elderly sample. 8733034 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE The angiotensin I converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism was proved to be involved in many pathophysiological conditions, including hypertension and IR. 22223701 2012
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Nonsteroidal anti-inflammatory drugs (NSAIDs) (OR: 6.839, 95 % CI = 4.392-10.648), angiotensin-converting enzyme inhibitors (ACEI) (OR: 7.846, 95 % CI = 5.161-11.928), angiotensin receptor blockers (ARB) (OR: 6.466, 95 % CI = 4.813-8.917), radiocontrast agents (OR: 8.850, 95 % CI = 5.857-13.372), hypertension (OR: 4.244, 95 % CI = 2.729-6.600), diabetes mellitus (OR: 2.303, 95 % CI = 1.411-3.761), heart failure (OR: 3.647, 95 % CI = 2.276-5.844) and presence of infection (OR: 3.149, 95 % CI = 1.696-5.845) were found as the risk factors for AKI-DO in elderly patients (p < 0.001 for all). 27704319 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE The combination of the angiotensin-converting enzyme inhibitor captopril and the hemorheological agent PTX, affecting various systems that are involved in blood pressure regulation, exhibits synergism and prevents an increase in arterial blood pressure during the development of arterial hypertension in SHRs (ie, from 5 to 11 weeks of life). 28989072 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Angiotensin-converting enzyme I/D polymorphism and hypertension: the Ohasama study. 12023681 2002
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE The aim of this work is to examine the association between hypertension and ACE I/D polymorphism, as well as the contribution of clinical and metabolic parameters on blood pressure. 21528810 2011
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Given the equal outcome efficacy but fewer adverse events with ARBs, risk-to-benefit analysis in aggregate indicates that at present there is little, if any, reason to use ACE inhibitors for the treatment of hypertension or its compelling indications. 29598869 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE We used this method to analyze a) a highly polymorphic pentanucleotide repeat (CCTTT)(n) locus within the 5'-putative promoter region of the human inducible nitric oxide synthase gene (iNOS5) which is associated with diabetic complications and infectious diseases; b) a bi-allelic 27 bp VNTR region within intron 4 of endothelial nitric oxide gene (eNOS27) which is associated with hypertension in type 2 diabetes patients with coronary heart disease and excess risk of advanced diabetic nephropathy in type 1 diabetes patients and c) an insertion/deletion polymorphism within the gene encoding angiotensin-converting enzyme (ACE/ID) which is associated with cardiovascular pathology and nitric oxide activity, and is in strong linkage disequilibrium with functional variants. 12554058 2003
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Initial treatment of hypertension in diabetes should include drug classes demonstrated to reduce cardiovascular events; i.e., angiotensin converting-enzyme inhibitors, angiotensin receptor blockers, diuretics, or dihydropyridine calcium channel blockers. 30140748 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE We examined the association between obesity and 13 angiotensin-converting enzyme (ACE) gene polymorphisms, including the presence (I) or absence (D) of an Alu element in intron 16 (I/D polymorphism), and performed haplotype analysis using data collected from participants of a community survey of hypertension among blacks living in Ibadan, Nigeria; Spanish Town, Jamaica; and Chicago, IL. 15919834 2005