Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Deletion polymorphism of the angiotensin-converting enzyme gene is independently associated with left ventricular mass and geometric remodeling in systemic hypertension. 8677872 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE The I/D polymorphism of the ACE gene is not a marker for either form of hypertension in this large elderly sample. 8733034 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE The DD genotype of the ACE gene is associated with PHS in patients with hypertension, which is independent of blood pressure levels or presence of cardiac hypertrophy. 8784123 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE The results indicate a lack of association between ACE I/D polymorphism and essential hypertension in this Greek population, suggesting that other genes must contribute to the pathogenesis of hypertension. 8806984 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Polymorphisms in the renin-angiotensin system, such as the recently described insertion/deletion polymorphism in the angiotensin I converting enzyme (ACE) gene, may predispose to hypertension and related disorders because of an advantage they confer in thermoregulation. 8822230 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Because ACE polymorphism modulates local production of angiotensin II, a powerful coronary vasoconstrictor, it may influence left ventricular mass in general as well as in coexisting disease states such as hypertension and cardiomyopathy. 8869131 1995
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Alterations in the expression or action of these components, which include angiotensin converting enzyme (ACE), angiotensinogen, and angiotensin II type-1 receptors, may contribute to the development of disease, such as hypertension, left ventricular hypertrophy, myocardial infarction, and end-stage heart failure. 8869132 1995
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Angiotensin-converting enzyme (ACE) gene polymorphism and the erythrocyte sodium-lithium countertransporter (SLC) phenotype in hypertension. 8872813 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE To investigate whether the polymorphisms in the angiotensin-converting enzyme and angiotensinogen genes are associated with hypertension, we carried out a case-control study of 508 hypertensive and 523 control subjects randomly selected from the Social Insurance Institution register. 8952598 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensinogen was selected because of the putative link between it and mild to moderate essential hypertension and nephrosclerosis; angiotensin-converting enzyme because of its possible contribution to diabetic nephropathy; and renin, the angiotensin II receptor, and kallikrein because of their roles in hypertension and renal perfusion. 8989734 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Associations of candidate loci angiotensinogen and angiotensin-converting enzyme with severe hypertension: The NHLBI Family Heart Study. 9034402 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Likewise, there was no significant association between the ACE or AGT genotype and hypertension. 9049480 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Deletion polymorphism in the angiotensin-converting enzyme gene is not associated with hypertension in a Gulf Arab population. 9137889 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Thus, we conclude that the deletion polymorphism of the ACE gene is significantly associated with male elderly hypertension, at least in this Chinese population. 9140789 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE We therefore examined the genotypic and allelic frequency distributions of the ACE gene I/D polymorphism in 55 patients with aldosterone-producing adenoma, APA, (angiotensin-unresponsive APA n = 28, angiotensin-responsive APA n = 27), and 80 control subjects with no family history of hypertension. 9140790 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Obese individuals (body mass index > 31) had significantly higher serum ACE and angiotensinogen levels, this relationship persisted for ACE in multivariate analyses controlling for BP, hypertension status, age, and gender. 9140797 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE The results indicated a much lower prevalence of ACE/DD genotype in Chinese than in Caucasians and a modest association between I/D polymorphism of the ACE gene and hypertension in Chinese. 9160768 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE To examine whether the angiotensinogen M235T and angiotensin converting enzyme insertion/deletion (I/D) variants are related to the severity of hypertension in patients with established essential hypertension. 9170002 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Casual blood pressure levels, 24 h, and daytime and nighttime ABP levels did not differ among the ACE genotype in patients with hypertension. 9234834 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE The frequent association of nephropathy with hypertension has led to research on the genes related to hypertension (ACE, angiotensinogen). 9257079 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE In addition, ACE genotypes were not significant predictors of insulin resistance and glucose intolerance either among men or among women after adjustment for age, body mass index, and hypertension. 9321743 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE The prevalence of the I allele of the ACE gene was not significantly increased in subjects with hypertension (73.1%), NIDDM (62.1%), and NIDDM with CHD (65%) compared with healthy controls. 9322809 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE No significant associations were detected between the ACE genotype and the development of hypertension, antihypertensive therapy required, progression rate of the disease, age of diagnosis and the antiproteinuric response to ACE-inhibition. 9352153 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE These findings raise the possibility that in some ethnic subgroups, variation in or near the ACE gene may contribute to the development, and severity, of hypertension. 9358012 1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Left ventricular hypertrophy, blood pressure and ACE genotype in untreated hypertension. 9364280 1997