Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE ACE I/D interacted with daily salt intake and correlated with hypertension (p for interaction = 0.047). 17283861 2006
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group LHGDN ACE I/D interacted with daily salt intake and correlated with hypertension (p for interaction = 0.047). 17283861 2006
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE ACE I/D genotypes were assessed in 158 hypertensive patients (71 +/- 9 years; 72 male) with AF and 174 patients with arterial hypertension in sinus rhythm (SR) (71 +/- 9 years; 88 male). 17927479 2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Angiotensin-converting enzyme insertion/deletion polymorphism has been shown to be associated with diabetes, hypertension, coronary artery diseases, and diabetic nephropathy. 18154415 2008
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE ACE I/D gene polymorphism is not a susceptibility factor to aortoiliac occlusive disease; however it may be an important factor in the development of AAA when coexisting with hypertension. 18718603 2009
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensin-converting enzyme (ACE) inhibitors reduce clinical symptoms and improve outcome in patients with hypertension, heart failure, and stable coronary artery disease (CAD) and are among the most frequently used drugs in these patient groups. 19082699 2009
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Angiotensin converting enzyme deletion genotype has been linked to hypertension and sarcoidosis and has been reported to regulate liver fibrosis in HCV-mediated liver disease. 19119484 2008
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Angiotensin converting enzyme gene polymorphism (insertion/deletion) and hypertension in adult Asian Indians: a population-based study from Calcutta, India. 19130799 2008
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE ACE polymorphism is not associated with the development of premature MI and this might be due to the low prevalence of hypertension in young coronary patients. 19552566 2009
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensin converting enzyme (ACE) inhibitors are used widely in therapy for hypertension, congestive heart failure and myocardial infarction. 19744011 2009
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE ACE D/D genotype was associated with hypertension (p = 0.004), peripheral vascular disease (p = 0.006), and previous myocardial infarction (p = 0.007). 21955693 2011
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Angiotensin-converting enzyme (ACE)2 is a recently described member of the RAS, and this study investigated whether ACE2 polymorphisms are associated with hypertension, left ventricular (LV) mass, and cardiac function in type 2 diabetes. 21993363 2012
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Angiotensin-I converting enzyme (ACE) is a significant component of RAS, and an insertion/deletion (I/D) polymorphism in its gene has been implicated in predisposition to hypertension. 22103580 2012
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE ACE rs4267385 was associated with older clinical coronary disease onset (P=0.008) and hypertension (P=0.013) onset, increased plasma creatinine (P=0.01), yet greater mortality (P=0.044). 22739771 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensin-converting enzyme (ACE) inhibitors and β-adrenoceptor antagonists (β-blockers) are medications that are important in the management of hypertension and heart failure. 23579966 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensin-converting enzyme (ACE) inhibitors are first-line therapy for the treatment of hypertension, congestive heart failure, and diabetic nephropathy. 23730990 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE ACE inhibitors are well tolerated drugs used in the treatment of hypertension and heart failure and would also treat antisocial behavior disorders. 23891037 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE ACE polymorphism I/D had no statistically significant association with increased OSA risk, but the II genotype of ACE may be a risk factor for OSA with hypertension in Asians. 24271410 2014
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE ACE gene deletion is a risk factor for hypertension but is not a risk factor for diabetes in elderly population. 24354906 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Angiotensin converting enzyme (ACE) polymorphism has been shown to be important in hypertension progression and also in diabetes complications, especially associated with heart disease. 26529791 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensin I-converting enzyme (ACE, EC.3.4.15.1) inhibitory peptide is an efficacious therapy for hypertension. 28321677 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensin-I-converting enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension. 28333109 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensin converting enzyme (ACE) is a well-known enzyme, largely studied for its action on hypertension, as it produces angiotensin II from angiotensin I. 28626916 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE ACE inhibition is a key purpose for hypertension treatment. 28910674 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensin converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARBs) are the most effective drugs for treating hypertension in diabetes, in the absence of contraindications. 28929319 2017