Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.700 AlteredExpression group BEFREE We also studied the expression of Sirt1, which regulates eNOS expression and Sirt3, which regulates SOD2 expression as possible epigenetic targets of enzyme expression involved in the long- term programming of hypertension. 30717220 2019
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.700 Biomarker group BEFREE To evaluate nonclassic AME (NC-AME) due to partial 11β-HSD2 insufficiency and its association with hypertension, mineralocorticoid receptor (MR) activation, and inflammatory parameters. 30239803 2019
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.700 Biomarker group BEFREE Total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein (apo) B, apolipoprotein A-I (apoA-I), LDL particle and HDL particle concentrations were all decreased in PA subjects vs control subjects and subjects with untreated hypertension (P < 0.016). 30372543 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker group BEFREE In pairings of APOE*4 with hypertension (HTN) and congestive heart failure (CHF), the variables contributed independently and additively to all-cause dementia risk. 31455442 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation group BEFREE APOE polymorphism is associated with blood lipid and serum uric acid metabolism in hypertension or coronary heart disease in a Chinese population. 31559922 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 GeneticVariation group BEFREE Mice selectively expressing PPARγ dominant negative mutation in vascular smooth muscle exhibit RhoBTB1-deficiency and hypertension. 30896450 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker group BEFREE A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups. 30726504 2019
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.700 GeneticVariation group BEFREE No significant association of proteinuria with IL-8 SNP or hypertension with selected eNOS and IL-8 SNPs was found. 31529205 2019
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.700 GeneticVariation group BEFREE Treatment with or without the signal transducer and activator of transcription 1 (STAT1) inhibitor fludarabine was performed in an endothelial nitric oxide synthase gene knockout-related (<i>Nos3<sup>-/-</sup></i>) mouse model with the hypertension phenotype of periodontitis induced by bacteria. 31329047 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 GeneticVariation group GWASCAT Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension. 31055733 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 Biomarker group BEFREE Pulmonary arterial remodelling by deficiency of peroxisome proliferator-activated receptor-γ in murine vascular smooth muscle cells occurs independently of obesity-related pulmonary hypertension. 30813929 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker group BEFREE We used a mouse model of sympathetic nervous system-driven hypertension on the atherosclerotic-prone apolipoprotein E-deficient background. 30361420 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.700 Biomarker group BEFREE Exploiting Drug-Apolipoprotein E Gene Interactions in Hypertension to Preserve Cognitive Function: The 3-City Cohort Study. 30292766 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 Biomarker group BEFREE We hypothesize that endothelial PPARγ (peroxisome proliferator-activated receptor-γ) provides cardiovascular protection in offspring from pregnancies complicated by hypertension. 31104564 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 Biomarker group BEFREE Mutual promotion of FGF21 and PPARγ attenuates hypoxia-induced pulmonary hypertension. 30714402 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.700 AlteredExpression group BEFREE The present study therefore investigated whether aortic MMP-2 activity is increased by oxidative stress in early hypertension and then contributes to hypertrophic arterial remodeling by reducing the levels of calponin-1. 30339939 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 AlteredExpression group BEFREE LncRNA AK094457 promotes AngII-mediated hypertension and endothelial dysfunction through suppressing of activation of PPARγ. 31404524 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.700 AlteredExpression group BEFREE Vascular MMP-2 expression and activity were assessed by gel zymography, Western blot, and in situ zymography increased with hypertension. 30399409 2019
Entrez Id: 335
Gene Symbol: APOA1
APOA1
0.700 Biomarker group BEFREE Baseline urinary Hcy-thiolactone/creatinine was significantly associated with plasma tHcy, ApoA1, glomerular filtration rate, potassium and pyridoxal 5'-phosphate (positively) and with age, hypertension, smoking, urinary creatinine, plasma bilirubin and kynurenine (negatively). 30193001 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 AlteredExpression group BEFREE Combined L-LAME and HF diet-induced hypertension is related to increased oxidative stress, inhibiting AMP-activated protein kinase (AMPK)/ peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) pathway and altered gut microbiota compositions. 31108332 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.700 GeneticVariation group BEFREE The associations of urinary cadmium with hypertension risk were modified by rs14070 (P-value for interaction = 0.022) and rs7201 (P-value for interaction = 0.009) in gene MMP-2. 30684802 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.700 GeneticVariation group BEFREE Polymorphisms in both the PPARG and AGTR1 genes were found to be significantly associated with hypertension. 29266977 2018
Entrez Id: 490
Gene Symbol: ATP2B1
ATP2B1
0.700 GeneticVariation group GWASCAT Interethnic analyses of blood pressure loci in populations of East Asian and European descent. 30487518 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.700 Therapeutic group RGD Hydrogen sulfide improves endothelial dysfunction in hypertension by activating peroxisome proliferator-activated receptor delta/endothelial nitric oxide synthase signaling. 29084084 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.700 Biomarker group BEFREE Nephron-Specific Disruption of Nitric Oxide Synthase 3 Causes Hypertension and Impaired Salt Excretion. 29997131 2018