Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Therefore, ACE could be a potential therapeutic target in regulating the conversion of angiotensin I to angiotensin II and eventually controlling hypertension. 30875817 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Angiotensin-converting enzyme (ACE) inhibitors are among the most common medications used to treat patients with concomitant diabetes and hypertension. 31489273 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Deletion Polymorphism of Angiotensin Converting Enzyme Gene is Associated with Left Ventricular Hypertrophy in Uighur Hypertension-Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) Patients. 31064975 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Urocortin 2 in patients with hypertension treated with angiotensin converting enzyme inhibitors or angiotensin receptor blockers. 31443094 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Being on an ACE inhibitor was inversely associated with optimal hypertension control (AOR 0.35; 95% CI 0.14 to 0.85). 31340960 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Introduction Angiotensin-converting enzyme inhibitors (ACEi) induced cough is still the greatest challenge in the continued utilization of ACEi for management of hypertension. 31700727 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation group BEFREE Due to prevalent comorbidities, such as hypertension and albuminuria, patients often receive other agents that alter intrarenal hemodynamics, including angiotensin converting enzyme inhibitors/angiotensin receptor blockers (ACEi/ARBs), calcium channel blockers (CCBs) and diuretics. 31142441 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Chronic treatment of hypertension or heart failure very often includes an angiotensin-converting enzyme inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs) as renin-angiotensin system inhibitors (RASi) treatments. 30836981 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE These findings suggest that PASE has the antihypertensive effect that may involve a mechanism of ACE inhibition and simultaneously protect organ damage against hypertension. 31114496 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Hypertension and albuminuria may herald diabetic nephropathy and require management with angiotensin converting enzyme (ACE) inhibition. 31384418 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE To evaluate, in patients with type 2 diabetes and hypertension, the effects of 6 months treatment with canagliflozin, or perindopril, an angiotensin converting enzyme inhibitor, on central BP and carotid-femoral pulse wave velocity (cfPWV). 30113526 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Hypertension is a serious threat to human health and food-derived angiotensin converting enzyme (ACE; EC 3.4.15.1) inhibitory peptides can be used to regulate high blood pressure without side effects. 29572755 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Whether ACE inhibition enhances Aβ42 aggregation or impairs human cognitive ability are very important issues for preventing AD onset and for optimal hypertension management. 31072831 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE The approach supports equivalence between drug classes for initiating monotherapy for hypertension-in keeping with current guidelines, with the exception of thiazide or thiazide-like diuretics superiority to angiotensin-converting enzyme inhibitors and the inferiority of non-dihydropyridine calcium channel blockers. 31668726 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE In utero UFP exposure induced increases in the PAH-biotransforming enzymes, intrauterine oxidative damage and inflammation and stimulated programming and activation of AT<sub>1</sub>R and ACE, which resulted in increased blood pressure in the PND 50 male offspring. 30691489 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE We calculated the morbidity hazard of Parkinson's disease diagnosis in users of β-blockers compared with non-users, as well as users of angiotensin-converting enzyme (ACE) inhibitors for hypertension, after adjusting for sex, age, weight, smoking status, cholesterol levels and use of statins, employing the Cox proportional hazard model. 30868473 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Hypertension treatment shifted from using angiotensin-converting enzyme inhibitors to angiotensin II receptor blockers. 30402961 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE To evaluate the clinical and cost impact of switching angiotensin receptor blockers (ARBs) to angiotensin-converting enzyme inhibitors (ACEIs) in patients with hypertension. 30601319 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 AlteredExpression group BEFREE The inhibition of angiotensin-converting enzyme activity has been one of the major strategies for treating hypertension. 31750488 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensin-converting enzyme (ACE) inhibitors are a commonly prescribed and effective medication to treat hypertension. 31843319 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Kinetic and thermodynamic parameters of binding revealed that onopordia is an acceptable ACE inhibitor and could treat hypertension. 30396392 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Food-derived angiotensin-converting enzyme inhibitory (ACEi) peptides have gained substantial interest as potential alternatives to synthetic drugs in the management of hypertension. 31353484 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Angiotensin-converting-enzyme inhibitors can provide additional risk reduction, especially in patients with diabetes or hypertension. 31728766 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Inhibitors of ACE are first line therapeutics used in the treatment of hypertension and related cardiovascular diseases. 31084594 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker group BEFREE Because hCE1 is critical for the activation of imidapril, an angiotensin-converting enzyme (ACE)-inhibitor prodrug prescribed to treat hypertension, the most potent inhibitors, TPHP and 4tBPDPP, and an environmentally relevant mixture (house dust) were further evaluated for their effect on imidapril bioactivation in vitro. 31268531 2019