Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression group BEFREE Blockade of endogenous Angiotensin II type I receptor agonistic autoantibody activity improves mitochondria reactive oxygen species and hypertension in a rat model of Preeclampsia. 31721604 2020
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE We hypothesized that AT1R couple with Gα12 and/or Gαq to produce sympatho-excitation and increase BP and downregulation of these Gα subunit proteins will attenuate Ang II dependent hypertension. 31677381 2020
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE We previously reported that hypertension in female growth-restricted offspring that is associated with early reproductive senescence and a shift in the testosterone-to-estradiol ratio at 12 months of age is abolished by AR (androgen receptor) blockade in conjunction with downregulation of renal AT1aR (angiotensin type 1a receptor) mRNA expression. 31378101 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression group BEFREE Our data indicate an essential and systemic role for TG2 in bridging inflammation to hypertension via its posttranslational modifications stabilizing AT1 receptor and sensitizing Ang II. 30715101 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE Telmisartan, widely prescribed for the treatment of hypertension, has an anti-inflammatory property in addition to being an angiotensin II type 1 receptor antagonist. 31330445 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE Angiotensin II type 1 receptor blockers prevent aortic arterial stiffness in elderly patients with hypertension. 30311805 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE Findings support that FPH is associated with a vascular hyper-sympathetic activation, involving a tonic facilitation of prejunctional AT1 receptors by endogenous Ang II, which can justify, at least in part, the development of hypertension. 30326265 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression group BEFREE Conclusions Ang II-induced hypertension is caused by AGTR1 overexpression in the kidneys via the upregulation of BubR1 and Nox4. 31787052 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT<sub>1</sub>R) blockers, current therapies for hypertension and related cardiovascular diseases are still inadequate. 31537750 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression group BEFREE The results suggest that parental hypertension results in elevated BP and autonomic dysfunction in adult male offspring through activation of AT1R pathway and inhibition of endogenous H<sub>2</sub>S production in the brain. 31607943 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE We investigated whether Ang II, via induction of AT1R and μ-opioid receptor (μOR) dimerization in the nucleus tractus solitarius (NTS), leads to progressive hypertension. 31755934 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE Losartan, an angiotensin II (Ang II) receptor blocker acting on the Ang II type-1 receptor (AT1R) subtype, is a prescription drug for treating hypertension. 30991833 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE AT1R-Abs (autoantibodies to the angiotensin II type 1 receptor) have been reported in patients with disorders associated with hypertension. 31476909 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE Losartan, an angiotensin II type 1 receptor (AT1R) antagonist widely used to treat hypertension, has been reported to have analgesic effects in several pain models. 31037647 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE Telmisartan (TEL), an angiotensin II type I receptor blocker and PPARγ partial agonist, has been used for to treat hypertension. 31606379 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE Central blockade of the AT1 receptor attenuates pressor effects via reduction of glutamate release and downregulation of NMDA/AMPA receptors in the rostral ventrolateral medulla of rats with stress-induced hypertension. 30842613 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE We aimed to synthesize epigenomic findings in HTN namely (a) angiotensin-converting enzyme 2 (ACE II) gene, (b) Toll-like receptor 2 (TLR2) gene, (c) interferon γ (IFN-γ) gene, and (d) Capping Actin Protein, Gelosin-Like (<i>CAPG</i>) <i>gene</i>, adducin 1(ADD1) gene, (e) Tissue inhibitor of metalloproteinase 3 (<i>TIMP3</i>), (f) mesoderm specific transcript (MEST) loci, (g) sodium channel epithelial 1 alpha subunit 2 (SCNN1B), (h) glucokinase (CKG) gene (i) angiotensin II receptor, type1 (AGTR1), and DNA methylation (mDNA). 31805646 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE Hypertension is also associated with B cell activation and production of autoantibodies (anti-Hsp70, anti-Hsp65, anti-Hsp60, anti-AT1R, anti-α1AR, and anti-β1AR). 31321561 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation group BEFREE Nonalcoholic fatty liver disease and hypertension are closely related but there has been little genetic evidence to link them.In this issue, Musso et al. provide evidence that a common variant in AGTR1 (A1166C) is associated with both incident hypertension and nonalcoholic fatty liver disease, as well as nonalcoholic steatohepatitis, fibrosis, dyslipidemia, and insulin resistance. 30951517 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 AlteredExpression group BEFREE Although exogenous angiotensin II (AngII) can increase NMDAR activity in the PVN, whether endogenous AT1 receptor-protein kinase C (PKC) activity mediates the augmented NMDAR activity of PVN presympathetic neurons in hypertension is unclear. 31241170 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation group BEFREE AGTR1 A1166C polymorphism predicted 9.8-year incident NAFLD (odds ratio: 1.67, 95% CI: 1.26-2.21) and hypertension (odds ratio: 1.49, 95% CI: 1.12-2.63) and 9-year increase in cardiovascular disease risk and endothelial dysfunction markers. 30920415 2019
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE Thus, we concluded that AT1 pathway plays a role in pulmonary vascular dysfunction by increasing oxidative stress and reducing NO bioavailability, thereby contributing to vascular remodeling and pulmonary hypertension of iron-overload. 29990562 2018
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 GeneticVariation group BEFREE Since Hap-I of the human AT1R gene is associated with hypertension in Caucasians, we generated transgenic (TG) mice with Hap-I and Hap-II and studied the physiological significance of high fat diet (HFD) on haplotype specific gene expression. 29036458 2018
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE AT1R antibody was associated with renal allograft loss (odds ratio of 13.1 [95% confidence interval 1.48-1728]), the presence of glomerulitis or arteritis, and significantly higher TNF-α, IL-1β, and IL-8 levels, but not rejection or hypertension. 28927645 2018
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.600 Biomarker group BEFREE To explore the roles of glutamate acid decarboxylase 65 (GAD65) and angiotensin II type 1 receptor (AT<sub>1</sub>R) in the action of renal sympathetic denervation (RSD) on obesity-induced hypertension in canines. 29172730 2018