Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 GeneticVariation group BEFREE Regarding to the (GT)n repeats, the LL genotype showed a higher odds ratio for the development of albuminuria only in patients with hypertension when compared to the S allele.In conclusion, the T(-413)A SNP in the HO-1 promoter is significantly associated with albuminuria development in type 2 diabetes patients, especially with longer duration and poor glycemic control. 26512585 2016
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 GeneticVariation group BEFREE HMOX1 rs743811 associated with chronic kidney disease stage (OR=3.0, P=0.0001) in the University of Illinois cohort and end-stage renal disease (OR=10.0, P=0.0003) in the Walk-Treatment of Pulmonary Hypertension and Sickle cell Disease with Sildenafil Therapy cohort. 26206798 2016
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 Biomarker group BEFREE Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans. 26516175 2016
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 Biomarker group BEFREE The impaired D5R regulation of HO-1 and ROS production contributes to the pathogenesis of hypertension in D5(-/-) mice. 23425954 2014
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 GeneticVariation group BEFREE We recently demonstrated that heme oxygenase-1 (HO-1) protects against hypertension in a rat model of placental ischemia; however, whether HO-1 regulation of β-ENaC contributes to the beneficial effects of HO-1 is unknown. 24553299 2014
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 AlteredExpression group BEFREE Heme oxygenase-1 induces 15-lipoxygenase expression during hypoxia-induced pulmonary hypertension. 23391748 2013
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 Therapeutic group CTD_human Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole. 22352330 2012
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 Therapeutic group CTD_human Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats. 22349312 2012
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 Biomarker group CTD_human Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole. 22352330 2012
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 Biomarker group CTD_human Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats. 22349312 2012
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 GeneticVariation group BEFREE Study on the association between environmental cadmium exposure, cytochrome P450-mediated 20-HETE, heme-oxygenase-1 polymorphism and hypertension in Thai population residing in a malaria endemic areas with cadmium pollution. 21787712 2012
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 AlteredExpression group BEFREE Mesenchymal stromal cells expressing heme oxygenase-1 reverse pulmonary hypertension. 20957739 2011
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 GeneticVariation group BEFREE Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population. 19886851 2010
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 Biomarker group BEFREE On balance, however, the strategies to target heme oxygenase-1 as described in this review offer promising therapeutic approaches to clinicians for the effective management of hypertension and renal function. 19027871 2009
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 AlteredExpression group BEFREE Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils. 18515325 2008
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 Biomarker group CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961 2007
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 Therapeutic group CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961 2007
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 AlteredExpression group BEFREE This study evaluated in 16 pediatric renal transplant patients, divided in two groups based on the presence of post-transplant hypertension, the oxidative stress status measuring the gene expression (reverse transcription-polymerase chain reaction) of two major oxidative stress-related proteins, p22(phox) and heme oxygenase-1 (HO-1). 16860128 2006
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 GeneticVariation group LHGDN The AA genotype of HMOX-1 is associated with an increased incidence of hypertension in women 12872043 2004
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 GeneticVariation group BEFREE The AA genotype of HMOX-1 is associated with an increased incidence of hypertension in women. 12872043 2004
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 Biomarker group RGD Selective regulation of blood pressure by heme oxygenase-1 in hypertension. 12215473 2002
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.600 AlteredExpression group BEFREE For comparison, HO-1 levels were assayed in RPE cells from four donor eyes with long-standing hypertension. 9134328 1997