Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 Biomarker group BEFREE We aimed to synthesize epigenomic findings in HTN namely (a) angiotensin-converting enzyme 2 (ACE II) gene, (b) Toll-like receptor 2 (TLR2) gene, (c) interferon γ (IFN-γ) gene, and (d) Capping Actin Protein, Gelosin-Like (<i>CAPG</i>) <i>gene</i>, adducin 1(ADD1) gene, (e) Tissue inhibitor of metalloproteinase 3 (<i>TIMP3</i>), (f) mesoderm specific transcript (MEST) loci, (g) sodium channel epithelial 1 alpha subunit 2 (SCNN1B), (h) glucokinase (CKG) gene (i) angiotensin II receptor, type1 (AGTR1), and DNA methylation (mDNA). 31805646 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 AlteredExpression group BEFREE Therefore it is of no surprise that animals with genetic alterations in the expression of ACE2 develop a diverse pattern of phenotypes ranging from hypertension, metabolic and behavioural dysfunctions, to impairments in serotonin synthesis and neurogenesis. 30443713 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 AlteredExpression group BEFREE Chronically, SAT mice exhibited a blunted blood pressure elevation and preserved ACE2 activity during development of salt-sensitive hypertension. 31564162 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 AlteredExpression group BEFREE Here, we studied the mRNA and protein expression of cardiac angiotensin-converting enzyme 2 (ACE2) in the chronic phase of a rat model of 2-kidney, 1-clip hypertension (2K1C), and the effects of 2-week alamandine infusion on blood pressure, cardiac indices, and ACE2 mRNA and protein expression in the hearts. 30956259 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 GeneticVariation group BEFREE Hypertension and hypertensive left ventricular hypertrophy are associated with ACE2 genetic polymorphism. 30917908 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 GeneticVariation group BEFREE Association of ACE2 genetic polymorphisms with hypertension-related target organ damages in south Xinjiang. 30542083 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 Biomarker group BEFREE Angiotensin-converting enzyme 2 (ACE2) in the brain plays beneficial roles in cardiovascular function in hypertension. 30318562 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 Biomarker group BEFREE Although these preliminary findings must be confirmed by further researches with larger sample size, we could observe that the integrative analysis of ACE and ACE2 can be an informative tool in hypertension understanding that needs to be explored in new studies. 31430320 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 Biomarker group BEFREE In this work, we hypothesized that RGZ exerts a PPAR<i>γ</i>-dependent regulation of blood pressure through modulation of angiotensin-converting enzyme (ACE)-type 2 (ACE2)/angiotensin-(1-7)/angiotensin II type-2 receptor (AT<sub>2</sub>R) axis in an experimental model of high blood pressure. 30863432 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 AlteredExpression group BEFREE The results indicated that taurine regulated the hypothalamus pituitary adrenal (HPA) axis of the renin-angiotensin-aldosterone system (RAAS) by inhibiting ACE gene and protein expressions and promoting ACE2 and HSP70 protein expressions, thereby contributing to the prevention of stress-induced hypertension. 28849507 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 PosttranslationalModification group BEFREE AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension. 29570986 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 AlteredExpression group BEFREE Thus, FGF21 protects against angiotensin II-induced hypertension and vascular impairment by activation of the ACE2/angiotensin-(1-7) axis via fine-tuning the multi-organ crosstalk between liver, adipose tissue, kidney, and blood vessels. 29706566 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 AlteredExpression group BEFREE Emerging evidence also suggests that, in part, the female protective phenotype against hypertension may be due to inceased ACE2 activity within cardiovascular regulatory regions of the brain, potentially mediated by estrogen. 29480460 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 AlteredExpression group BEFREE Previous studies showed that injection of the enzymatic ectodomain of recombinant ACE2 (rACE2) markedly increases circulatory levels of ACE2 activity, and effectively lowered blood pressure in angiotensin II-induced hypertension. 29691064 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 Biomarker group BEFREE We find no influence of ACE2 gene polymorphism on stroke recurrence and only find possible interaction between hypertension history and the ACE2 gene in male stroke patients. 30056001 2018
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 Biomarker group BEFREE Elevated plasma ACE2 was associated with older age, male gender, hypertension and vascular disease, elevated left ventricular (LV) mass, impaired LV diastolic function and advanced atrial disease (P < 0.05 for all). 27738071 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 Biomarker group BEFREE The present review examined recent findings regarding the physiological and biological roles of the ACE2‑Ang‑(1‑7)‑Mas axis in the cardiovascular system, discussed potential food‑derived ACE2‑activating agents, and highlighted initiatives, based on this axis, that aim to develop functional foods for the treatment of hypertension. 28791402 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 Biomarker group BEFREE These results suggest that insufficiency of hypothalamic ACE2 is associated with hypertension in SHR rats. 28423630 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 Biomarker group BEFREE However, the newly discovered angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7)/Mas receptor axis added new vitality to the hypertension field. 28500596 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 Biomarker group BEFREE Large body of experimental data confirmed sustained beneficial effects of ACE2/Ang-(1-7)/Mas receptor axis activation on hypertension and vascular injury. 27889958 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 Biomarker group BEFREE ACE2 is important in understanding the balance between AngII and Ang-(1-7) and how this balance could then in turn influence hypertension or other disease outcomes. 28500595 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 Biomarker group BEFREE In order to assess the role of brain ACE2 in hypertension, a specific ACE2 assay is required. 28116711 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 AlteredExpression group BEFREE We previously reported that it is also associated with a reduction of angiotensin-converting enzyme type 2 (ACE2) and an increase in a disintegrin and metalloprotease 17 (ADAM17) activity in experimental hypertension. 28512108 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 GeneticVariation group BEFREE The study identified ACE II genotype (odds ratio = 3.02; 95% CI 1.40-6.51), smoking, hypertension, diabetes and serum triglyceride > 150 mg/dl as independent risk factors for MI. 26687160 2016
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.600 GeneticVariation group BEFREE The circulating ACE2 and Ang-(1-7) levels were related to neither rs4646155 nor rs879922 in female or male patients.In conclusion, the rs2106809 polymorphism of the ACE2 gene may be a determinant of the circulating Ang-(1-7) level in female patients with hypertension, suggesting a genetic association between circulating Ang-(1-7) levels and ACE2 gene polymorphisms in patients with hypertension. 27310975 2016