Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 Biomarker phenotype CTD_human Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension. 23502781 2013
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 Biomarker phenotype CTD_human Abnormal trafficking of endogenously expressed BMPR2 mutant allelic products in patients with heritable pulmonary arterial hypertension. 24224048 2013
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 Biomarker phenotype CTD_human Our study suggests that exposure with a mild Th2 antigen can trigger pulmonary hypertension on the background of the expression of a hypomorphic BMPR2 gene and that conversely, the expression of the hypomorphic BMPR2 gene can alter the immune response to a mild, inhaled antigen. 23383100 2013
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 Biomarker phenotype CTD_human Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo. 20522807 2010
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 Biomarker phenotype CTD_human We describe the case of an 83-year-old man with a family history of pulmonary hypertension (PH) who presented with severe pulmonary arterial hypertension (PAH) and later tested positive for a novel bone morphogenetic protein receptor 2 (BMPR2) gene mutation. 20496075 2010
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 GeneticVariation phenotype LHGDN A novel mutation in the BMPR2 gene in familial pulmonary arterial hypertension. 18364108 2008
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 Biomarker phenotype CTD_human Simvastatin enhances bone morphogenetic protein receptor type II expression. 16297860 2006
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 GeneticVariation phenotype LHGDN Gross BMPR2 gene rearrangements constitute a new cause for primary pulmonary hypertension. 15775752 2005
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 Biomarker phenotype LHGDN BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways. 15516492 2005
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 GeneticVariation phenotype LHGDN BMPR2 mutations have short lifetime expectancy in primary pulmonary hypertension. 15965979 2005
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 GeneticVariation phenotype LHGDN These results indicate that a substantial portion of Japanese PPH patients carry BMPR2 mutations with considerable heterogeneity. 15146475 2004
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 GeneticVariation phenotype LHGDN Identification of a novel mutation in the gene for bone morphogenetic protein receptor II in an Israeli patient with familial primary pulmonary hypertension. 15055271 2004
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 GeneticVariation phenotype LHGDN Primary pulmonary hypertension in children may have a different genetic background than in adults. 15295086 2004
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 Biomarker phenotype CTD_human BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives. 12358323 2002
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 Biomarker phenotype CTD_human Bone morphogenetic protein receptor 2 mutations in pulmonary hypertension. 11893684 2002
Entrez Id: 659
Gene Symbol: BMPR2
BMPR2
0.370 Biomarker phenotype CTD_human The increased incidence of the disease in young women, the familial cases, the association with autoimmune disorders, and the recent discovery that mutation of the PPH1 gene may not be restricted to familial PPH support the hypothesis that the development of pulmonary hypertension likely implies an individual susceptibility or predisposition, which is probably genetically determined. 11590841 2001