Gene: LEP ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.650 Biomarker disease BEFREE The observed link between hyperleptinemia and hypogonadism is in line with previous evidence on direct effects of leptin on testosterone production. 28366446 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.650 AlteredExpression disease BEFREE Mice fed IED showed severe hypogonadism with a significant reduction of serum levels of testosterone (-83%) and of luteinizing hormone (-86%), as well as reduced body weight gain, body fat and plasma leptin. 28648620 2017
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.650 Therapeutic disease RGD 7α-methyl-19-nortestosterone vs. testosterone implants for hypogonadal osteoporosis: a preclinical study in the aged male orchidectomized rat model. 21790658 2011
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.650 GeneticVariation disease BEFREE A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. 20382689 2010
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.650 Biomarker disease BEFREE Leptin replacement rescues the phenotype of morbid obesity and hypogonadism in leptin-deficient adults. 18854428 2008
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.650 Therapeutic disease CTD_human Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. 15070752 2004
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.650 Biomarker disease CTD_human Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. 15070752 2004
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.650 GeneticVariation disease BEFREE We have previously demonstrated that genetically based leptin deficiency due to a missense leptin gene mutation in a highly consanguineous extended Turkish pedigree is associated with morbid obesity and hypogonadism. 10523015 1999
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.650 Biomarker disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.650 Therapeutic disease CTD_human A leptin missense mutation associated with hypogonadism and morbid obesity. 9500540 1998
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.650 Biomarker disease HPO