Body weight (BW) gain and composition, food intake and key metabolic parameters, including glucose tolerance, were comparatively analyzed, in lean and obesogenic conditions, in mice lacking kisspeptin signaling due to global inactivation of Gpr54 (displaying profound hypogonadism; Gpr54<sup>-/-</sup>) vs. Gpr54 null mice with selective re-introduction of Gpr54 expression only in GnRH cells (Gpr54<sup>-/-</sup>Tg), where kisspeptin signaling elsewhere than in GnRH neurons is ablated but gonadal function is preserved.