Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7200
Gene Symbol: TRH
TRH
0.290 Biomarker disease BEFREE Due to case reports of thyroid dysfunction in 18q deletions and the well-established association between hypothyroidism and aneusomies, we undertook thyroid testing in all individuals and completed TRH studies on 50 of them. 15671099 2005
Entrez Id: 7200
Gene Symbol: TRH
TRH
0.290 Biomarker disease BEFREE The syndrome is characterized by: adipsia-hypodipsia (5/5 patients), recurrent hypernatremia (5/5), obesity (4/5), inability to excrete a water load (5/5), lack of growth hormone release in response to provocative stimuli (4/4), blunted thyrotropin releasing hormone responses (3/4), hypothyroidism (2/4), and hyperlipemia associated with hypernatremic crisis (1/1). 6808452 1982
Entrez Id: 7200
Gene Symbol: TRH
TRH
0.290 Biomarker disease BEFREE Thyrotropin-releasing hormone (TRH) is a tripeptide hormone produced by the hypothalamus in response to hypothyroidism. 15328193 2004
Entrez Id: 7200
Gene Symbol: TRH
TRH
0.290 Biomarker disease BEFREE In addition, the absence of hypothyroidism and normal responsiveness of serum TSH to TRH and L-triiodothyronine administration in untreated family members suggest that the thyroid has compensated for the hormone resistance by increased secretory activity under the control of pituitary TSH secretion. 6792914 1981
Entrez Id: 7200
Gene Symbol: TRH
TRH
0.290 Biomarker disease BEFREE However, an abnormally exaggerated TSH response to TRH was observed not only in the hypothyroid patients but also in six of the other subjects, indicating a decreased thyroid feedback at the pituitary level in the presence of a normal serum concentration of thyroid hormones. 487612 1979
Entrez Id: 7200
Gene Symbol: TRH
TRH
0.290 Biomarker disease BEFREE It is suggested that 1) among euthyroid relatives with a family history of Graves' disease, there are many with abnormalities in TRH responsiveness and T3 suppressibility, 2) nonsuppressible subjects are more likely to be TRH hyporesponders and vice versa, 3) hyperthyroidism or hypothyroidism occurs frequently in euthyroid relatives with a family history of Graves' disease, and 4) thyrotoxicosis occurs frequently in TRH-hyporesponders, and hypothyroidism occurs in the others. 6774999 1980
Entrez Id: 7200
Gene Symbol: TRH
TRH
0.290 Biomarker disease RGD Our results show that 6-n-propyl-2-thiouracil (PTU) treatment producing hypothyroidism induced a significant increase in the expression of PC1/3, PC2, and pro-TRH in the PVN and LH, but not VMN. 16926379 2007
Entrez Id: 7200
Gene Symbol: TRH
TRH
0.290 AlteredExpression disease BEFREE Basal thyrotropin levels were low despite hypothyroidism and increments were less than 3 micromicron per milliliter after thyrotropin-releasing hormone injection. 628396 1978
Entrez Id: 7200
Gene Symbol: TRH
TRH
0.290 AlteredExpression disease BEFREE Homozygous subjects displayed mild hypothyroidism confirmed by moderately elevated basal TSH levels and excessive TSH response to TRH administration. 17526952 2006
Entrez Id: 7200
Gene Symbol: TRH
TRH
0.290 AlteredExpression disease BEFREE Also, we demonstrated that TRH Receptor 1 (TRH-R1) is colocalized in NEI immunoreactive neurons in the peduncular part of the lateral hypothalamus (PLH) and NEI precursor mRNA expression increased by hypothyroidism indicating that NEI neurons are responsive to the feedback mechanisms of the Hypothalamic Pituitary-Thyroid Axis (HPT). 30590076 2019