Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8647
Gene Symbol: ABCB11
ABCB11
0.010 Biomarker disease BEFREE The frequency of hypothyroidism and subclinical hypothyroidism was significantly higher than in patients with ABCB11 deficiency (5/13 vs 0/19, P = .006) and in patients without ATP8B1 or ABCB11 mutations (5/13 vs 0/15, P = .013). 26382629 2015
Entrez Id: 368
Gene Symbol: ABCC6
ABCC6
0.100 Biomarker disease HPO
Entrez Id: 368
Gene Symbol: ABCC6
ABCC6
0.100 CausalMutation disease CLINVAR
Entrez Id: 9744
Gene Symbol: ACAP1
ACAP1
0.100 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.010 AlteredExpression disease BEFREE Blockade of renin and inhibition of angiotensin-converting enzyme both resulted in a rebound increase in level of renin in hypothyroid rats. 31396276 2019
Entrez Id: 43
Gene Symbol: ACHE
ACHE
0.030 Biomarker disease BEFREE This study investigated the effects of (MMI)-induced hypothyroidism on the NTPDase, 5'-nucleotidase, adenosine deaminase (ADA), and acetylcholinesterase (AChE) activities in synaptosomes of rats and whether the quercetin can prevent it. 26879755 2017
Entrez Id: 43
Gene Symbol: ACHE
ACHE
0.030 GeneticVariation disease BEFREE A single amino acid change in the acetylcholinesterase-like domain of thyroglobulin causes congenital goiter with hypothyroidism in the cog/cog mouse: a model of human endoplasmic reticulum storage diseases. 9707574 1998
Entrez Id: 43
Gene Symbol: ACHE
ACHE
0.030 AlteredExpression disease BEFREE Moreover, hypothyroidism significantly decreased the content of ACh (29.8%) and activity of AChE (27.8%), which were restored to control values by T4 admi-nistration. 28713915 2017
Entrez Id: 54
Gene Symbol: ACP5
ACP5
0.100 Biomarker disease HPO
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.020 Biomarker disease BEFREE Moreover, there was an intralobular inflammatory reaction associated with significant (p<0.05) increases in the density of resident hepatic macrophages [cluster of differentiation 68 (CD68)+ cells], as well as in activated hepatic stellate cells, alpha-smooth muscle actin (α-SMA) index in livers with hypothyroidism. 31658321 2019
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.020 AlteredExpression disease BEFREE A single large dose of L-triiodothyronine given to hypothyroid rats caused a 4.7-fold increase in myocardial HCN2 mRNA expression level and only a 2.3-fold increase in the beta-actin mRNA level. 10488052 1999
Entrez Id: 100
Gene Symbol: ADA
ADA
0.120 AlteredExpression disease BEFREE This study demonstrates that hypothyroidism interferes with adenine nucleoside and nucleotide hydrolysis and this is correlated with oxidative stress, which might be responsible for the increase in ADA activity. 29090621 2018
Entrez Id: 100
Gene Symbol: ADA
ADA
0.120 AlteredExpression disease BEFREE On the other hand, adenosine deaminase (ADA) activity was increased in hyperthyroidism (75%), and nucleotide pyrophosphatase/phosphodiesterase (NPP) activity was increased in animals with hypothyroidism (127%) and those with hyperthyroidism (128%). 29663535 2018
Entrez Id: 100
Gene Symbol: ADA
ADA
0.120 Biomarker disease HPO
Entrez Id: 103
Gene Symbol: ADAR
ADAR
0.100 Biomarker disease HPO
Entrez Id: 113
Gene Symbol: ADCY7
ADCY7
0.100 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.010 AlteredExpression disease BEFREE Serum leptin and adiponectin expression in MOAT were altered by hypothyroidism. 31004687 2019
Entrez Id: 23394
Gene Symbol: ADNP
ADNP
0.100 GeneticVariation disease CLINVAR
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
0.210 Biomarker disease RGD Northern blot analysis of poly(A)+ RNA from hypothyroid rat interscapular brown adipose tissue demonstrated that the levels of beta 1- and beta 2-AR mRNA per tissue are decreased by 73% and 58% respectively, whereas in hypothyroid heart, only the beta 1-AR mRNA is decreased, by 43%. 1651697 1991
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
0.210 AlteredExpression disease BEFREE (4) beta(2)-AR mRNA levels were measured by real-time PCR during ontogenic development as well as during exposure of 10-day-old hypothyroid cultures to normal levels of thyroid hormone for 2, 6, 12, and 24 h. None of the conditions caused any significant change in the beta(2)-adrenergic receptor mRNA levels when compared with corresponding hypothyroid controls. 17828453 2007
Entrez Id: 177
Gene Symbol: AGER
AGER
0.010 GeneticVariation disease BEFREE Further analysis demonstrated that an oxidative stress cut-off value of 590 μmol/L is associated with an increased risk of progression of Hashimoto's thyroiditis from euthyroidism to hypothyroidism; this risk is further increased in carriers of the RAGE -429T>C polymorphism. 28226412 2017
Entrez Id: 27161
Gene Symbol: AGO2
AGO2
0.100 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.020 AlteredExpression disease BEFREE Both angiotensin I and II were significantly (P <0.05) lower than normal levels in the hypothyroid rats, unlike the level of aldosterone, which was higher than normal level. 31396276 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.020 Biomarker disease BEFREE Eplerenone indicated a significant increase in renin and angiotensin I from 184.09 pg/ml and 178.66 pg/ml to 603.31 pg/ml and 250.88 pg/ml, respectively, meanwhile, aldosterone indicated no significant changes after inducing hypothyroidism and eplerenone administration. 31579950 2019
Entrez Id: 196
Gene Symbol: AHR
AHR
0.010 Biomarker disease BEFREE COP subjects had a significantly higher risk for hypothyroidism than non-COP subjects (adjusted hazard ratio [AHR]: 3.8; 95% confidence interval [CI]: 3.2-4.7) after adjusting for age, sex, underlying comorbidities, and monthly income, and the AHR was particular higher in subjects with diabetes mellitus, hyperlipidemia, and mental disorder. 31712674 2019