Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE Congenital hypothyroidism (CH) due to thyroglobulin (TG) deficit is an autosomal recessive disease (OMIM #274700) characterized by hypothyroidism, goiter, low serum TG, and a negative perchlorate discharge test. 23455760 2013
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE Serum Tg was 264 ng/mL while on L-thyroxine for hypothyroidism and to obtain thyrotropin suppression. 20718682 2010
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE The thymuses of these DS individuals contained significantly lower levels of AIRE and thyroglobulin, to which tolerance is typically lost in autoimmune thyroiditis leading to hypothyroidism. 25217160 2014
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE Hashimoto's thyroiditis was also diagnosed because she had a diffuse goiter and a mild hypothyroidism (TSH 8.20 μU/mL, and FT4 0.80 ng/mL) with positive autoantibodies for thyroid peroxidase and thyroglobulin. 29459556 2018
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease BEFREE New insights into thyroglobulin gene: molecular analysis of seven novel mutations associated with goiter and hypothyroidism. 23164529 2013
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE The effect of oral administration of iodine to patients with goiter and hypothyroidism due to defective synthesis of thyroglobulin. 8777378 1996
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE The association of clinical and biological hypothyroidism with undetectable levels of serum thyroglobulin (Tg) and the presence of iodohistidines in the urine suggested the diagnosis of defective Tg gene expression. 3745406 1986
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease BEFREE The results of the present study suggested that specific Tg gene alleles or genotypes were correlated with AITD; specific Tg SNP haplotypes were associated with hypothyroidism, hyperthyroidism and Hashimoto's disease, and the Tg SNP frequency distribution differed depending on the geographical location of the Han Chinese populations. 26099577 2015
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease BEFREE Recurrence of the p.R277X/p.R1511X compound heterozygous mutation in the thyroglobulin gene in unrelated families with congenital goiter and hypothyroidism: haplotype analysis using intragenic thyroglobulin polymorphisms. 17911408 2007
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE Out of 15 patients with EVA, goiter was present in 8 (53%), hypothyroidism in 7 (47%), increased serum thyroglobulin levels in 8 (53%) and a positive perchlorate discharge test in 10 (67%). 15279074 2004
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE We found that loss of Vps34 in thyrocytes causes (i) disorganization of thyroid parenchyma, with abnormal thyrocyte and follicular shape and reduced PAS<sup>+</sup> colloidal spaces; (ii) severe noncompensated hypothyroidism with extremely low T4 levels (0.75 ± 0.62 μg/dL) and huge thyrotropin plasma levels (19,300 ± 10,500 mU/L); (iii) impaired <sup>125</sup>I organification at comparable uptake and frequent occurrence of follicles with luminal Tg but nondetectable T4-bearing Tg; (iv) intense signal in thyrocytes for the lysosomal membrane marker, LAMP-1, as well as Tg and the autophagy marker, p62, indicating defective lysosomal proteolysis; and (v) presence of macrophages in the colloidal space. 31650902 2020
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease BEFREE A novel missense mutation (G2320R) in thyroglobulin causes hypothyroidism in rdw rats. 11089535 2000
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease BEFREE Evidence for the segregation of three different mutated alleles of the thyroglobulin gene in a Brazilian family with congenital goiter and hypothyroidism. 9588493 1998
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE In this report, we use the change in thyroglobulin and thyroid antibody levels in patients on immune therapy who develop hypothyroidism to better understand its pathogenesis as well as examine the status of hypothyroidism in the long term. 28073132 2017
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE Mutations causing hypothyroidism might induce solely local/regional misfolding or may interfere more globally by impeding interactions between regions that are required for thyroglobulin secretion. 21636579 2011
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease BEFREE In this paper, we briefly review three such conditions, including familial neurohypophyseal diabetes insipidus, insulin-deficient diabetes mellitus, and hypothyroidism with defective thyroglobulin. 31605742 2020
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE Both patients presented with neonatal diabetes mellitus, severe resistant hypothyroidism in the presence of elevated thyroglobulin and normal thyroid anatomy, degenerative liver disease, cystic renal dysplasia, recurrent infections and facial dysmorphism. 21139041 2011
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE Nivolumab-induced immune thrombocytopenia and hypothyroidism were suspected based on the presence of platelet-associated IgG, an increased level of autoantibodies to thyroglobulin and thyroid peroxidase and an enlarged thyroid gland. 29260625 2018
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE 15.5% (11/71) were hypothyroid, 17 (23.9%) were positive for thyroid peroxidase (TPO) and/or thyroglobulin (Tg) antibodies, and 24 (33.8%) had thyromegaly. 10776989 2000
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease BEFREE A 3' splice site mutation in the thyroglobulin gene responsible for congenital goiter with hypothyroidism. 1752952 1991
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE Thyrotropin and free thyroxine confirmed hypothyroidism; low thyroglobulin and radioiodine uptake indicated near absence of thyroid tissue. 30412041 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE Forty-eight hour radioiodine uptake, peak serum TSH, and stimulated serum Tg levels after administration of rhTSH are repeatable between studies, demonstrating reproducibility of diagnostic results without rendering patients hypothyroid. 17021814 2007
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE Hyperthyroidism in Graves' disease is caused by thyroid-stimulating autoantibodies to the TSH receptor (TSHR), whereas hypothyroidism in Hashimoto's thyroiditis is associated with thyroid peroxidase and thyroglobulin autoantibodies. 17823263 2007
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE TPO and thyroglobulin antibody levels at baseline may be predictive of hypothyroidism. 28882978 2018
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease BEFREE A single amino acid change in the acetylcholinesterase-like domain of thyroglobulin causes congenital goiter with hypothyroidism in the cog/cog mouse: a model of human endoplasmic reticulum storage diseases. 9707574 1998