Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.050 Biomarker disease BEFREE In particular, hypophysitis is the most frequent anti-CTLA-4-antibodies-related irAE, while thyroid abnormalities (as hypothyroidism, thyrotoxicosis, painless thyroiditis, or even "thyroid storm") are more frequently associated with anti-PD-1-antibodies. 30242549 2018
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.050 Biomarker disease BEFREE <b>Methods:</b> We report a case series of 10 patients who developed hypothyroidism after initiation of immune therapy (either anti-PD-1 alone or in combination with anti-CTLA-4). 28073132 2017
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.050 GeneticVariation disease BEFREE We also show suggestive evidence of association for hypothyroidism with a SNP in the HLA class II region (independent of the other HLA association) as well as SNPs in CAPZB, PDE8B, and CTLA4. 22493691 2012
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.050 Biomarker disease LHGDN Here we identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4)--which encodes a vital negative regulatory molecule of the immune system--as candidates for primary determinants of risk of the common autoimmune disorders Graves' disease, autoimmune hypothyroidism and type 1 diabetes. 12724780 2003
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.050 GeneticVariation disease LHGDN The aim of this study was to determine whether allelic association was present between the A-G single nucleotide polymorphism (SNP) at position 49 in exon 1 of the CTLA-4 gene and autoimmune hypothyroidism. 11842815 2002