The levels of serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), IL-12, IL-10, (FINS), and homeostasis model assessment of insulin resistance (HOMA-IR) were gradually declined in sequence of hypothyroidism group, normal thyroid group, and control group (P < 0.05).
In the present study we investigated the effect of radioactive iodine (I-131)-induced hypothyroidism on several parameters of vascular function, such as nitric oxide (NO), total nitric oxide synthase (NOS) activity and expression of NOS isoforms, as well as on interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) as indicators of inflammation, in rats.
Levels of pro‑inflammatory cytokines including interleukin (IL)‑1β, IL‑6 and tumor necrosis factor‑α were significantly higher in the hippocampal homogenates of hypothyroid rats.