Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE Premenopausal women with overt hypothyroidism (thyroid-stimulating hormone [TSH] > 15 IU/L) were tested in the early follicular phase of their natural menstrual cycles or after a progesterone challenge for gonadotropins, estradiol (E<sub>2</sub>), and prolactin (PRL). 31259157 2019
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE Hypothyroidism resulted in irregularity of oestrus cycle accompanied with decrease in luteinizing hormone (LH), follicular stimulating hormone (FSH) and estradiol (E2), while prolactin (PRL), progesterone (P) and testosterone (T) hormone were significantly elevated. 30403603 2018
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE LHX3 mutations are associated with growth hormone, prolactin, gonadotropin, and TSH deficiency; abnormal pituitary morphology; and may be accompanied with limited neck rotation and sensorineural hearing loss. 21249393 2011
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE POU1F1 (Pit-1; Gene ID 5449) is an anterior pituitary transcriptional factor, and POU1F1 mutation is known to cause anterior pituitary hypoplasia, growth hormone and prolactin deficiency and various degree of hypothyroidism. 21316014 2011
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 GeneticVariation disease BEFREE Mutations within POU1F1 are associated with GH, TSH and PRL deficiencies, with the TSH deficiency being highly variable. 18174732 2007
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE Most of the affected individuals manifest GH, prolactin, and TSH deficiency. 15928241 2005
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE The genetic abnormalities include mutations within: (1) Hesx1 (IGHD, SOD or CPHD); (2) Lhx3 (CPHD with preservation of cortisol secretion and a short stiff neck); (3) Lhx4 (GH, TSH and ACTH deficiency with cerebellar hypoplasia); (4) Prop1 (variable CPHD often associated with pituitary masses); (5) POU1F1 (GH, prolactin and TSH deficiency); (6) GHRHR (IGHD) and (7) GH1 (IGHD). 12914740 2003
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE Pit-1 gene mutations result in complete growth hormone (GH) and PRL deficiencies and variable degrees of TSH deficiency, producing the clinical syndrome of combined pituitary hormone deficiency (CPHD). 9588494 1998
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE We report a child whose hypothyroidism was recognized clinically at age 6 weeks, and subsequently found to have GH and Prl as well as TSH deficiency. 9485179 1998
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE All had complete GH deficiency and complete or partial Prl and TSH deficiency. 9632165 1998
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE These patients present extreme short stature, GH, PRL and TSH deficiency but intact ACTH, LH and FSH secretion.The pituitary is usually hypoplastic. 9699131 1998
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE These patients present extreme short stature, GH, PRL and TSH deficiency but intact ACTH, LH and FSH secretion.The pituitary is usually hypoplastic. 9438923 1997
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE Studies of kindreds with GH, Prl and TSH deficiency have disclosed a variety of mutations in the Pit-1 gene. 8300051 1993
Entrez Id: 5617
Gene Symbol: PRL
PRL
0.100 Biomarker disease BEFREE Four out of 10 children in two unrelated families presented with a total pituitary growth hormone (GH) and prolactin deficiency and a partial thyrotropin (TSH) deficiency.The GH gene was intact in family I. 2634610 1989