Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 AlteredExpression disease BEFREE Previous studies have shown that thyroid peroxidase antibody is associated with homocysteine levels in hypothyroidism. 29966154 2020
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE In this study, a dual effect polymeric system was designed to release Cepharanthine (CEP) to block T cell activation and Selenium (Se) to decrease the anti-thyroid peroxidase (TPOAb) concentration in order to treat hypothyroidism. 31788940 2020
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE We collected information on thyroid-specific phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, thyroid volume) and other clinical phenotypes (age, body surface area, number of hypothyroidism symptoms, blood pressure) from 290 patients with HT without levothyroxine (LT4) therapy with the aim to test for correlations between thyroid-specific and clinical phenotypes. 30332318 2019
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 AlteredExpression disease BEFREE Women with the lowest ovarian reserves had higher levels of TPO Ab, with a positive trend of this antibody overtime in comparison to other quartiles, indicating that this group may be at a higher risk of hypothyroidism over time. 31064360 2019
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE In patients who have circulating thyroid peroxidase antibodies, there is a greater risk of progression from subclinical to overt hypothyroidism. 31287527 2019
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE Isolated hypothyroidism was rare (n=2) and late (median: 30 weeks).Three patients had anti-TPO antibodies. 31005502 2019
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE By multivariate analysis, background thyroiditis (relative risk [RR], 9.78; p = 0.004), thyroid peroxidase antibody positivity (RR, 9.90; p = 0.003), nodule size (RR, 1.24; p < 0.001), and initial TSH (RR, 1.47; p = 0.009) were the independent risk factors for predicting hypothyroidism in euthyroid patients. 29529842 2019
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 GeneticVariation disease BEFREE Thyroid abnormalities were detected in 45 (52.3%) patients, including 28 (32.3%) hypothyroidism, 3 (3.5%) hyperthyroidism and 20 (23.3%) thyroperoxidase antibody positivity. 31780218 2019
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 GeneticVariation disease BEFREE However, the subset of hypothyroidism single-nucleotide polymorphisms involved in autoimmunity and thyroid peroxidase antibodies levels were not associated with AF. 30673084 2019
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE To assess the effect of iodine on hypothyroidism in TPO Ab positive or negative populations, the weighted prevalence of hypothyroidism was assessed in each population according to UIC or estimated iodine intake subgroups. 30276524 2019
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 GeneticVariation disease GWASCAT Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. 30367059 2018
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 AlteredExpression disease BEFREE TPO and thyroglobulin antibody levels at baseline may be predictive of hypothyroidism. 28882978 2018
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE It is characterized as both cellular immune responses with T, B cells infiltrating to the thyroid gland followed by hypothyroidism as a result of destruction of the thyroid follicles and fibrous replacement of the parenchymal tissue, as well as immune response for TPO and Tg-antibody production. 30093941 2018
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE Nivolumab-induced immune thrombocytopenia and hypothyroidism were suspected based on the presence of platelet-associated IgG, an increased level of autoantibodies to thyroglobulin and thyroid peroxidase and an enlarged thyroid gland. 29260625 2018
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE P38/TRHr-Dependent Regulation of TPO in Thyroid Cells Contributes to the Hypothyroidism of Triclosan-Treated Rats. 29462796 2018
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE Hashimoto's thyroiditis was also diagnosed because she had a diffuse goiter and a mild hypothyroidism (TSH 8.20 μU/mL, and FT4 0.80 ng/mL) with positive autoantibodies for thyroid peroxidase and thyroglobulin. 29459556 2018
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 GeneticVariation disease BEFREE Women positive for TPOAb are at a significant risk of developing hypothyroidism during pregnancy and postpartum. 28102101 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE 05 to 2.89), female gender (odds ratio, 2.02; 95 % confidence interval, 1.05 to 3.87), and positive thyroid peroxidase antibody (odds ratio, 4.99; 95 % confidence interval, 2.83 to 8.79) were associated with higher odds of hypothyroidism among type 2 diabetes mellitus inpatients. 27605039 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE Criteria for early diagnosis of hypothyroidism (i.e., sensitivity of 94% and specificity of 82%, p < 0.0001) were obtained based on baseline and three-year follow-ups of thyroid function tests and thyroid peroxidase antibody. 28071990 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE There were no clear differences between groups for low birthweight (average RR 0.56; 95% CI 0.26 to 1.23, two trials, 377 infants, no statistical heterogeneity, low-quality evidence), neonatal hypothyroidism/elevated thyroid-stimulating hormone (TSH) (average RR 0.58; 95% CI 0.11 to 3.12, two trials, 260 infants, very low-quality evidence) or the adverse effect of elevated neonatal thyroid peroxidase antibodies (TPO-ab) (average RR 0.61; 95% CI 0.07 to 5.70, one trial, 108 infants, very low-quality evidence). 28260263 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE The risk of developing hypothyroidism was higher in the patients with repeated allo-HSCTs (P=0.024) and with positive TPO antibodies (P=0.045). 28433882 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 GeneticVariation disease BEFREE Determination of anti-TPO antibody levels and exon 12 TPO gene polymorphisms in patients with SCH can be helpful for prediction of overt hypothyroidism. 28500830 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE The proportion of hypothyroidism was calculated and thyroid peroxidase antibodies (TPO) in serum were measured. 27861716 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.200 Biomarker disease BEFREE With this approach, TPO antibody titers over 17 IU/ml indicated hypothyroidism with a 90% sensitivity and 75% sensibility. 28954485 2017