Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7252
Gene Symbol: TSHB
TSHB
0.430 Biomarker disease BEFREE Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence. 30448824 2018
Entrez Id: 7252
Gene Symbol: TSHB
TSHB
0.430 Biomarker disease CTD_human Amiodarone-induced myxoedema coma. 24729111 2014
Entrez Id: 7252
Gene Symbol: TSHB
TSHB
0.430 Biomarker disease CTD_human Induced hypothyroidism accelerates the regression of liver fibrosis in rats. 18031379 2007
Entrez Id: 7252
Gene Symbol: TSHB
TSHB
0.430 Biomarker disease BEFREE Thyroid-stimulating antibody was detected in the hyperthyroid patient, and TSHB-ab was found in one of eight patients with hypothyroid AT. 8664977 1996
Entrez Id: 7252
Gene Symbol: TSHB
TSHB
0.430 GeneticVariation disease BEFREE Pituitary adenomas and activating mutations of the TSH receptor gene (Parma et al., 1993) cause hyperthyroidism and TSH beta gene defects (Hayashizaki et al., 1989) and inactivating mutations of the TSH receptor gene (Sunthornthepvarakul et al., 1995) cause hypothyroidism. 9039330 1996
Entrez Id: 7252
Gene Symbol: TSHB
TSHB
0.430 Biomarker disease HPO
Entrez Id: 7201
Gene Symbol: TRHR
TRHR
0.410 AlteredExpression disease BEFREE Taken together, p38/TRHr-dependent regulation of TPO in thyroid cells contributes to the hypothyroidism of triclosan-treated rats. 29462796 2018
Entrez Id: 7201
Gene Symbol: TRHR
TRHR
0.410 Biomarker disease CTD_human A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene. 9141550 1997
Entrez Id: 7201
Gene Symbol: TRHR
TRHR
0.410 Biomarker disease HPO
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE We found that loss of Vps34 in thyrocytes causes (i) disorganization of thyroid parenchyma, with abnormal thyrocyte and follicular shape and reduced PAS<sup>+</sup> colloidal spaces; (ii) severe noncompensated hypothyroidism with extremely low T4 levels (0.75 ± 0.62 μg/dL) and huge thyrotropin plasma levels (19,300 ± 10,500 mU/L); (iii) impaired <sup>125</sup>I organification at comparable uptake and frequent occurrence of follicles with luminal Tg but nondetectable T4-bearing Tg; (iv) intense signal in thyrocytes for the lysosomal membrane marker, LAMP-1, as well as Tg and the autophagy marker, p62, indicating defective lysosomal proteolysis; and (v) presence of macrophages in the colloidal space. 31650902 2020
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease BEFREE In this paper, we briefly review three such conditions, including familial neurohypophyseal diabetes insipidus, insulin-deficient diabetes mellitus, and hypothyroidism with defective thyroglobulin. 31605742 2020
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE Thyrotropin and free thyroxine confirmed hypothyroidism; low thyroglobulin and radioiodine uptake indicated near absence of thyroid tissue. 30412041 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE ER stress contributes to high-fat diet-induced decrease of thyroglobulin and hypothyroidism. 30620634 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE We collected information on thyroid-specific phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, thyroid volume) and other clinical phenotypes (age, body surface area, number of hypothyroidism symptoms, blood pressure) from 290 patients with HT without levothyroxine (LT4) therapy with the aim to test for correlations between thyroid-specific and clinical phenotypes. 30332318 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE Hashimoto's thyroiditis was also diagnosed because she had a diffuse goiter and a mild hypothyroidism (TSH 8.20 μU/mL, and FT4 0.80 ng/mL) with positive autoantibodies for thyroid peroxidase and thyroglobulin. 29459556 2018
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE Nivolumab-induced immune thrombocytopenia and hypothyroidism were suspected based on the presence of platelet-associated IgG, an increased level of autoantibodies to thyroglobulin and thyroid peroxidase and an enlarged thyroid gland. 29260625 2018
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE TPO and thyroglobulin antibody levels at baseline may be predictive of hypothyroidism. 28882978 2018
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease BEFREE Molecular analysis of thyroglobulin mutations found in patients with goiter and hypothyroidism. 29275168 2018
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE Severely low serum magnesium is associated with increased risks of positive anti-thyroglobulin antibody and hypothyroidism: A cross-sectional study. 29967483 2018
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE In this report, we use the change in thyroglobulin and thyroid antibody levels in patients on immune therapy who develop hypothyroidism to better understand its pathogenesis as well as examine the status of hypothyroidism in the long term. 28073132 2017
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 AlteredExpression disease BEFREE The high prevalence of reversible hypothyroidism and the TSH-dependent elevation of the serum Tg levels was suggested in Japanese patients with advanced CKD. 28291505 2017
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 Biomarker disease BEFREE We recently demonstrated in Ctns(-/-) mice that altered thyroglobulin biosynthesis associated with endoplasmic reticulum stress, combined with defective lysosomal processing, caused hypothyroidism. 26812160 2016
Entrez Id: 7038
Gene Symbol: TG
TG
0.400 GeneticVariation disease BEFREE The results of the present study suggested that specific Tg gene alleles or genotypes were correlated with AITD; specific Tg SNP haplotypes were associated with hypothyroidism, hyperthyroidism and Hashimoto's disease, and the Tg SNP frequency distribution differed depending on the geographical location of the Han Chinese populations. 26099577 2015