Therefore, our findings demonstrate that Hoxc13<sup>-/-</sup> rabbits can be used as a model for human ECTD-9, especially to understand the pathologic mechanism of hypotrichosis.
Ectodermal dysplasia-9 (ED-9) is a congenital condition characterized by hypotrichosis and nail dystrophy without other disorders, and Hoxc13 is a pathogenic gene for ED-9.