Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 Biomarker disease BEFREE Our findings demonstrate that B-cell clonality is a common finding in AILT and PTCL-NOS, and its presence should not negate the diagnosis established by morphologic, immunophenotypic, and clinical findings. 16931587 2006
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 Biomarker disease BEFREE The recent identification of follicular helper T (T(FH)) cell as the cell of origin of this neoplasm represents a major step in our understanding of the pathobiological characteristics of the disease and should, in the future, clarify the diagnostic criteria for AITL and help to delineate its spectrum, especially from PTCL, not otherwise specified (PTCL, NOS). 19961485 2010
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 AlteredExpression disease BEFREE Among PTCL-NOS, a heterogeneous group of lymphoma-comprising cases likely to derive from Th follicular (T(FH)) cells similarly to AITL, TET2 mutations were more frequent when PTCL-NOS expressed T(FH) markers and/or had features reminiscent of AITL (58% vs 24%, P = .01). 22760778 2012
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 Biomarker disease BEFREE We correlated EBV localization with clinicopathologic findings in PTCL-NOS (n = 63) and AITL (n = 26). 24180328 2014
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 GeneticVariation disease BEFREE These analyses identified highly recurrent epigenetic factor mutations in TET2, DNMT3A and IDH2 as well as a new highly prevalent RHOA mutation encoding a p.Gly17Val alteration present in 22 of 35 (67%) angioimmunoblastic T cell lymphoma (AITL) samples and in 8 of 44 (18%) PTCL, not otherwise specified (PTCL-NOS) samples. 24413734 2014
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 Biomarker disease BEFREE This method could serve as a novel diagnostic tool for 60-70% of AITL and AITL-like PTCL-NOS. 25310466 2014
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 Biomarker disease BEFREE PTCL-NOS shared a similar pattern of ITK and SYK gains with AITL. 25337257 2014
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 Biomarker disease BEFREE The miRNA profile of PTCLs/NOS then was compared with that of 10 angioimmunoblastic T-cell lymphomas (AITLs), 6 anaplastic large-cell lymphomas (ALCLs)/ALK+ and 6 ALCLs/ALK-. 25382608 2014
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 GeneticVariation disease BEFREE Recently, a novel recurring somatic mutation in RHOA, encoding p.Gly17Val, was discovered in nearly 70% of AITLs and in a smaller proportion of peripheral T-cell lymphomas, not otherwise specified (PTCL-NOS). 26574844 2016
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 Biomarker disease BEFREE Two residues-D124 and T195-were recurrently mutated in 11.3% of cases of AITL and in one case of PTCL, not otherwise specified (PTCL-NOS). 26719098 2016
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 Biomarker disease BEFREE A total of 321 patients, newly diagnosed with PTCL-NOS (n = 180) or AITL (n = 141) between 1999 and 2015, were analysed. 27983760 2017
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 GeneticVariation disease BEFREE First-line CHOP and CHOP-like regimens were used in 74% of patients, providing 4-year overall survival (OS) outcomes of 34% (95% confidence interval [CI], 14%-83%) in patients without transplant consolidation (82% in ALCL, 37% in PTCL-NOS, and 0% in AITL). 28622960 2017
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 Biomarker disease BEFREE In total, 97 patients with AITL (n=37), PTCL-NOS (n=40), ALK-negative ALCL (n=11), or ALK-positive ALCL (n=9) were treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone). 29100307 2017
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 AlteredExpression disease BEFREE Interestingly, BCL-6 expression was the only T<sub>FH</sub> marker differentially expressed between AITL and PTCL-NOS cases. 29662631 2018
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 GeneticVariation disease BEFREE Gene expression profiling (GEP) defined molecular signatures for AITL and delineated biological and prognostic subgroups within PTCL-NOS (PTCL-GATA3 and PTCL-TBX21). 30782609 2019
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 GeneticVariation disease BEFREE The RHOA G17V mutation was found in 15 (75%) of 20 AITL and two (22%) of nine PTCL, NOS. 31394087 2019