Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.400 GeneticVariation disease BEFREE In order to identify cases with IDH2 mutations, 50 cases previously diagnosed as angioimmunoblastic T-cell lymphoma were subjected to next-generation sequencing analysis using a custom panel covering four genes frequently mutated in angioimmunoblastic T-cell lymphoma including DNMT3A, TET2, IDH2 and RHOA. 30952970 2019
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.400 GeneticVariation disease BEFREE Interestingly, TET2 mutations were identified in 32 of 33 (97%) cases with IDH2<sup>R172</sup> and/or RHOA<sup>G17V</sup> mutations whereas only 55% of angioimmunoblastic T-cell lymphoma cases wild-type for these two genes carried TET2 mutations (p = 0.0022). 30952970 2019
Entrez Id: 387
Gene Symbol: RHOA
RHOA
0.400 GeneticVariation disease BEFREE The RHOA G17V mutation was found in 15 (75%) of 20 AITL and two (22%) of nine PTCL, NOS. 31394087 2019
Entrez Id: 387
Gene Symbol: RHOA
RHOA
0.400 Biomarker disease BEFREE Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma. 28832024 2018
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.400 GeneticVariation disease BEFREE These results suggest that a combination of immunohistochemistry and AS-PCR or NGS should be considered for the identification of IDH2 mutations in AITL in a routine setting. 29981867 2018
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.400 Biomarker disease BEFREE Recent sequencing studies have clarified the recurrent mutations in ras homology family member A (RHOA) and in genes encoding epigenetic regulators, tet methyl cytosine dioxygenase 2 (TET2), DNA methyl transferase 3 alpha (DNMT3A) and isocitrate dehydrogenase 2, mitochondrial (IDH2), as well as those related to the T-cell receptor signaling pathway in AITL. 28889481 2018
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.400 Biomarker disease BEFREE Recent sequencing studies have clarified the recurrent mutations in ras homology family member A (RHOA) and in genes encoding epigenetic regulators, tet methyl cytosine dioxygenase 2 (TET2), DNA methyl transferase 3 alpha (DNMT3A) and isocitrate dehydrogenase 2, mitochondrial (IDH2), as well as those related to the T-cell receptor signaling pathway in AITL. 28889481 2018
Entrez Id: 387
Gene Symbol: RHOA
RHOA
0.400 GeneticVariation disease BEFREE Detection of the G17V RHOA mutations assists prompt and appropriate diagnosis of AITL. 29493850 2018
Entrez Id: 387
Gene Symbol: RHOA
RHOA
0.400 Biomarker disease BEFREE Recent genetic analysis has identified frequent mutations in ten-eleven translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase 2 (IDH2) and ras homolog family member A (RHOA) in nodal T-cell lymphomas, including angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified. 28157189 2017
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.400 GeneticVariation disease BEFREE Recent genetic analysis has identified frequent mutations in ten-eleven translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase 2 (IDH2) and ras homolog family member A (RHOA) in nodal T-cell lymphomas, including angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified. 28157189 2017
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.400 GeneticVariation disease BEFREE Recent genetic studies identified that the disease-specific G17V RHOA mutation, together with mutations in TET2, DNMT3A, and IDH2, is a hallmark of angioimmunoblastic T cell lymphomas (AITL). 28634614 2017
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.400 Biomarker disease BEFREE Thus, TET2-mutated haematopoietic precursor cells in AITL patients not only give rise to the T-cell lymphoma but also generate a large population of mutated mature B cells. 28337768 2017
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.400 GeneticVariation disease BEFREE Response to 5-azacytidine in a patient with TET2-mutated angioimmunoblastic T-cell lymphoma and chronic myelomonocytic leukaemia preceded by an EBV-positive large B-cell lymphoma. 27353473 2017
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.400 Biomarker disease BEFREE Recent genetic analysis has identified frequent mutations in ten-eleven translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase 2 (IDH2) and ras homolog family member A (RHOA) in nodal T-cell lymphomas, including angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified. 28157189 2017
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.400 GeneticVariation disease BEFREE Angioimmunoblastic T-cell lymphomas (AITLs) frequently carry mutations in the TET2 and IDH2 genes. 28337768 2017
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.400 GeneticVariation disease BEFREE Expression of TFH Markers and Detection of RHOA p.G17V and IDH2 p.R172K/S Mutations in Cutaneous Localizations of Angioimmunoblastic T-Cell Lymphomas. 28945625 2017
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.400 AlteredExpression disease BEFREE Here, we have demonstrated that TET2 loss and RhoAG17V expression in mature murine T cells cooperatively cause abnormal CD4+ T cell proliferation and differentiation by perturbing FoxO1 gene expression, phosphorylation, and subcellular localization, an abnormality that is also detected in human primary AITL tumor samples. 28691928 2017
Entrez Id: 387
Gene Symbol: RHOA
RHOA
0.400 GeneticVariation disease BEFREE Recent genetic studies identified that the disease-specific G17V RHOA mutation, together with mutations in TET2, DNMT3A, and IDH2, is a hallmark of angioimmunoblastic T cell lymphomas (AITL). 28634614 2017
Entrez Id: 387
Gene Symbol: RHOA
RHOA
0.400 GeneticVariation disease BEFREE Expression of TFH Markers and Detection of RHOA p.G17V and IDH2 p.R172K/S Mutations in Cutaneous Localizations of Angioimmunoblastic T-Cell Lymphomas. 28945625 2017
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.400 GeneticVariation disease BEFREE Here, we investigated the impact of TET2 mutations on methylation of BCL6 locus in human AITL/PTCL samples. 27921272 2017
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.400 GeneticVariation disease BEFREE These results confirm that TET2 mutation is an early event in the majority of AITL cases, and that the driving molecular anomalies are not restricted to the T lineage tumour cells. 28543514 2017
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.400 GeneticVariation disease BEFREE Genome wide sequencing studies have dissected the repertoire of the genetic alterations driving AITL uncovering a highly recurrent Gly17Val somatic mutation in the small GTPase RHOA and major role for mutations in epigenetic regulators, such as TET2, DNMT3A and IDH2, and signaling factors (e.g., FYN and CD28). 27177312 2016
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.400 GeneticVariation disease BEFREE Recently, mutations in TET2 and other epigenetic modifiers as well as RHOA have been identified in these diseases, particularly in angioimmunoblastic T-cell lymphoma (AITL). 26719098 2016
Entrez Id: 387
Gene Symbol: RHOA
RHOA
0.400 GeneticVariation disease BEFREE Among these, CCR4 expression and the CD21(+) network in RHOA-mutated AITL cases were more extensive than in the RHOA mutation-negative AITL cases (P<0.05). 27158755 2016
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.400 GeneticVariation disease BEFREE Genome wide sequencing studies have dissected the repertoire of the genetic alterations driving AITL uncovering a highly recurrent Gly17Val somatic mutation in the small GTPase RHOA and major role for mutations in epigenetic regulators, such as TET2, DNMT3A and IDH2, and signaling factors (e.g., FYN and CD28). 27177312 2016