Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 94
Gene Symbol: ACVRL1
ACVRL1
0.010 Biomarker disease BEFREE 9p24 gains were detected in 6/17 (35%) primary mediastinal B-cell lymphomas (PMBCLs), 25/77 (33%) Hodgkin's lymphomas (HLs), 3/16 (19%) angioimmunoblastic T-cell lymphomas (AILTs) and 1/5 ALK1(+) anaplastic large cell lymphomas (ALCLs); breaks were observed only in three cases. pJAK2 expression was most prevalent in PMBCL, peripheral T-cell lymphomas and HL. pSTAT3 predominated in ALCLs, HLs, AILTs, PMBCLs and peripheral T-cell lymphomas. pSTAT5 expression was detected frequently in follicular lymphomas, diffuse large B-cell lymphomas and AILTs. 19136931 2009
Entrez Id: 6590
Gene Symbol: SLPI
SLPI
0.010 Biomarker disease BEFREE 9p24 gains were detected in 6/17 (35%) primary mediastinal B-cell lymphomas (PMBCLs), 25/77 (33%) Hodgkin's lymphomas (HLs), 3/16 (19%) angioimmunoblastic T-cell lymphomas (AILTs) and 1/5 ALK1(+) anaplastic large cell lymphomas (ALCLs); breaks were observed only in three cases. pJAK2 expression was most prevalent in PMBCL, peripheral T-cell lymphomas and HL. pSTAT3 predominated in ALCLs, HLs, AILTs, PMBCLs and peripheral T-cell lymphomas. pSTAT5 expression was detected frequently in follicular lymphomas, diffuse large B-cell lymphomas and AILTs. 19136931 2009
Entrez Id: 6962
Gene Symbol: TRBV20OR9-2
TRBV20OR9-2
0.030 Biomarker disease BEFREE Angioimmunoblastic T cell lymphoma (AILT) is a rare lymphoma that is regarded as a clinicopathologic entity but shows considerable histomorphologic diversity, variable immunophenotypes and inconsistent T cell receptor (TCR) gene rearrangement. 12455048 2003
Entrez Id: 10563
Gene Symbol: CXCL13
CXCL13
0.060 Biomarker disease BEFREE Angioimmunoblastic T-cell lymphoma (AITL) comprises CD4+ CXCL13+ neoplastic cells displaying overlapping immunophenotypical and molecular features with normal follicular helper T cells. 19074096 2008
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE Angioimmunoblastic T-cell lymphoma (AITL) has increased neoplastic follicular-helper T cells (FHT), which often express CD10; but nonneoplastic, CD10-positive T cells may be associated with reactive lymphadenopathy and with B-cell lymphomas. 25619965 2016
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.400 GeneticVariation disease BEFREE Angioimmunoblastic T-cell lymphomas (AITLs) frequently carry mutations in the TET2 and IDH2 genes. 28337768 2017
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.020 AlteredExpression disease BEFREE BCL2 expression in CD105 positive neoangiogenic cells and tumor progression in angioimmunoblastic T-cell lymphoma. 22322190 2012
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
0.390 GeneticVariation disease BEFREE DNMT3A mutations occurred in 28 (33%) AITLs; 100% of these also harbored TET2 mutations (P < .0001). 24345752 2014
Entrez Id: 54790
Gene Symbol: TET2
TET2
0.400 GeneticVariation disease BEFREE TET2 loss-of-function mutations are highly frequent in subtypes of T-cell lymphoma that harbor follicular helper T (Tfh)-cell-like features, such as angioimmunoblastic T-cell lymphoma (30-83%) or peripheral T-cell lymphoma, not otherwise specified (10-49%), as well as myeloid malignancies. 25501021 2014
Entrez Id: 50616
Gene Symbol: IL22
IL22
0.010 Biomarker disease BEFREE IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma. 26363366 2015
Entrez Id: 10563
Gene Symbol: CXCL13
CXCL13
0.060 Biomarker disease BEFREE CXCL13 was a relatively sensitive marker in AITL, expressed in 84% of tested cases; however, only 3% of PTCL-NOS cases were tested. 28209473 2017
Entrez Id: 3135
Gene Symbol: HLA-G
HLA-G
0.010 Biomarker disease BEFREE B2 microglobulin is a novel prognostic marker of Angioimmunoblastic T-cell lymphoma. 30150635 2018
Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH
0.010 AlteredExpression disease BEFREE GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-κB-Dependent Mechanism. 31447347 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.020 GeneticVariation disease BEFREE A p53 gene mutation was only found in 1 case (1/8 cases) of angioimmunoblastic lymphoma, which showed cytologic tumor progression. 11230707 2001
Entrez Id: 387
Gene Symbol: RHOA
RHOA
0.400 Biomarker disease CTD_human A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma. 24584070 2014
Entrez Id: 4842
Gene Symbol: NOS1
NOS1
0.100 Biomarker disease BEFREE A total of 321 patients, newly diagnosed with PTCL-NOS (n = 180) or AITL (n = 141) between 1999 and 2015, were analysed. 27983760 2017
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 Biomarker disease BEFREE A total of 321 patients, newly diagnosed with PTCL-NOS (n = 180) or AITL (n = 141) between 1999 and 2015, were analysed. 27983760 2017
Entrez Id: 9332
Gene Symbol: CD163
CD163
0.010 Biomarker disease BEFREE Accordingly, the response to CHOP chemotherapy was significantly worse in the high IL-10 group, and infiltration of CD163-positive M2 macrophages was significantly associated with OS in AITL. 29100307 2017
Entrez Id: 387
Gene Symbol: RHOA
RHOA
0.400 Biomarker disease BEFREE Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma. 28832024 2018
Entrez Id: 2146
Gene Symbol: EZH2
EZH2
0.010 AlteredExpression disease BEFREE Additionally, 67.5% of patients with PTCL-NOS, 50% of patients with NK/TCL, 73.3% of patients with ALCL and 60% of patients with AITL highly expressed EZH2. 31423206 2019
Entrez Id: 1380
Gene Symbol: CR2
CR2
0.020 Biomarker disease BEFREE AITL cases were more likely than PTCL-TFH cases to contain expanded CD21-positive follicular dendritic cell meshworks, clear cell cytology and polymorphous inflammatory background; however, there was a significant (P<0.005) Kruskal-Wallis trend in all morphologic variables between the 3 groups suggesting a continuum from PTCL-NOS to PTCL-TFH to AITL. 31283630 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.020 Biomarker disease BEFREE ALRN-6924 induced a complete remission in a patient with TP53-wild-type angioimmunoblastic T-cell lymphoma, demonstrating the potential for rapid translation of discoveries from subtype-specific preclinical models. 29789628 2018
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.400 GeneticVariation disease BEFREE Although IDH2 mutations are largely confined to AITL, mutations of the other 3 can be found in other types of PTCL, although at lower frequencies. 26268241 2015
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
0.390 Biomarker disease BEFREE Although frequent mutations in TET2, IDH2 and DNMT3A, which are common to various hematologic malignancies, have been identified in AITL, the molecular pathogenesis specific to this lymphoma subtype is unknown. 24413737 2014
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 AlteredExpression disease BEFREE Among PTCL-NOS, a heterogeneous group of lymphoma-comprising cases likely to derive from Th follicular (T(FH)) cells similarly to AITL, TET2 mutations were more frequent when PTCL-NOS expressed T(FH) markers and/or had features reminiscent of AITL (58% vs 24%, P = .01). 22760778 2012