Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.020 AlteredExpression group BEFREE In vivo, increased monocyte ABCA1 expression in untreated HIV-infected patients and normalization of ABCA1 expression with virological suppression by ART supports direct HIV-induced impairment of cholesterol efflux previously demonstrated in vitro. 23204179 2013
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.020 AlteredExpression group BEFREE In both alcohol using HIV-positive human subjects and in vitro studies of alcohol with HIV-1 gp120 protein in peripheral blood mononuclear cells, increased ROS production significantly affected redox expression in glutathione synthetase (GSS), super oxide dismutase (SOD), and glutathione peroxidase (GPx), and subsequently impacted lipid rafts Cav-1, ABC transporters ABCA1, ABCG1, ABCB1, and ABCG4, and SREBP transcription. 29132227 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.010 AlteredExpression group BEFREE In both alcohol using HIV-positive human subjects and in vitro studies of alcohol with HIV-1 gp120 protein in peripheral blood mononuclear cells, increased ROS production significantly affected redox expression in glutathione synthetase (GSS), super oxide dismutase (SOD), and glutathione peroxidase (GPx), and subsequently impacted lipid rafts Cav-1, ABC transporters ABCA1, ABCG1, ABCB1, and ABCG4, and SREBP transcription. 29132227 2018
Entrez Id: 9619
Gene Symbol: ABCG1
ABCG1
0.010 AlteredExpression group BEFREE In both alcohol using HIV-positive human subjects and in vitro studies of alcohol with HIV-1 gp120 protein in peripheral blood mononuclear cells, increased ROS production significantly affected redox expression in glutathione synthetase (GSS), super oxide dismutase (SOD), and glutathione peroxidase (GPx), and subsequently impacted lipid rafts Cav-1, ABC transporters ABCA1, ABCG1, ABCB1, and ABCG4, and SREBP transcription. 29132227 2018
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.020 AlteredExpression group BEFREE This article suggests for the first time that the redox inhibition affects lipid rafts, ABC-transporter, and SREBP transcription and modulates AA metabolites, serving as an important intermediate signaling network during immune cell dysfunction in HIV-positive alcohol users. 29132227 2018
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.020 Biomarker group BEFREE Epirubicin (EPI)-loaded lipid microbubbles (MBs) conjugated with anti-ABCG2 monoclonal antibody (EPI-MBs + mAb) were developed and their effect on MM 138<sup>-</sup>CD34<sup>-</sup> CSCs isolated from human MM RPMI 8226 cell line plus ultrasound exposure in vitro and in vivo in a nonobese diabetic/severe combined immunodeficient mouse model were assessed. 29784015 2018
Entrez Id: 64137
Gene Symbol: ABCG4
ABCG4
0.010 AlteredExpression group BEFREE In both alcohol using HIV-positive human subjects and in vitro studies of alcohol with HIV-1 gp120 protein in peripheral blood mononuclear cells, increased ROS production significantly affected redox expression in glutathione synthetase (GSS), super oxide dismutase (SOD), and glutathione peroxidase (GPx), and subsequently impacted lipid rafts Cav-1, ABC transporters ABCA1, ABCG1, ABCB1, and ABCG4, and SREBP transcription. 29132227 2018
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.050 Biomarker group BEFREE There are currently three established CML mouse models: the BCR-ABL transgenic model, the BCR-ABL retroviral transduction/transplantation model, and the xenotransplant immunodeficient model. 27581149 2016
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.050 AlteredExpression group BEFREE Leukemic (Ph(+)/BCR-ABL(+)) cells with in vitro progenitor activity and capable of engrafting immunodeficient mice were identified in the directly isolated G(0) cells. 10477735 1999
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.050 Biomarker group BEFREE Injection of immunodeficient mice with BCR/ABL-positive p53-/- cells produced a transplantable, highly aggressive, poorly differentiated acute myelogenous leukemia. 8917557 1996
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.050 Biomarker group BEFREE BCR-ABL-transduced human cord blood cells produce abnormal populations in immunodeficient mice. 15674417 2005
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.050 Biomarker group BEFREE Transferred BCR/ABL DNA from K562 extracellular vesicles causes chronic myeloid leukemia in immunodeficient mice. 25133686 2014
Entrez Id: 27034
Gene Symbol: ACAD8
ACAD8
0.010 Biomarker group BEFREE When compared with IBD diagnosed in older children, VEO-IBD has some distinct characteristics such as a higher likelihood of an underlying monogenic etiology or primary immune deficiency. 31833544 2019
Entrez Id: 65057
Gene Symbol: ACD
ACD
0.100 Biomarker group HPO
Entrez Id: 22985
Gene Symbol: ACIN1
ACIN1
0.010 Biomarker group BEFREE We have previously shown that the ACN NB cell line is tumorigenic and angiogenic in immunodeficient mice, and that interferon-gamma (IFN-gamma) gene transfer dampens ACN tumorigenicity. 16721359 2006
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.020 Biomarker group BEFREE Using a combination of overexpression and RNA interference, we establish that CXCR7 promotes growth of tumors formed from breast and lung cancer cells and enhances experimental lung metastases in immunodeficient as well as immunocompetent mouse models of cancer. 17898181 2007
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.020 Biomarker group BEFREE Hltf deletion altered transcription of trophoblast lineage-specific genes, and increased transcription of the Cxcr7 (p = 0.004) gene whose protein product is a co-receptor for human and simian immunodeficiency viruses. 29975766 2018
Entrez Id: 23205
Gene Symbol: ACSBG1
ACSBG1
0.010 Biomarker group BEFREE Previous studies from our group have demonstrated the antitumor efficacy of systemically administered, folate-targeted, lipid-protamine-DNA complexes (LPD-PEG-Folate) against breast cancer using an immunodeficient xenogenic murine model. 14671672 2004
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.130 Biomarker group BEFREE Our findings reveal an α-actinin-mediated dynamic cortical actin rearrangement for HIV entry, and identify an antiviral target as well as a corresponding peptide inhibitor based on HIV interaction with the actin cytoskeleton. 31773115 2020
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.130 Biomarker group HPO
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.130 GeneticVariation group BEFREE The Wiskott-Aldrich syndrome protein (WASp) is a key regulator of the actin cytoskeleton in hematopoietic cells and mutated in two severe immunodeficiency diseases with high incidence of cancer. 30393584 2018
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.130 Biomarker group BEFREE Immunodeficient mice with bone marrow transplantation from the cytomegalovirus enhancer/chicken β-actin promoter-enhanced green fluorescent protein mice were used for the in vivo experiments. 27742059 2016
Entrez Id: 10121
Gene Symbol: ACTR1A
ACTR1A
0.010 Biomarker group BEFREE Orally administered MucoRice-ARP1 markedly decreased the viral load in immunocompetent and immunodeficient mice. 23925294 2013
Entrez Id: 91
Gene Symbol: ACVR1B
ACVR1B
0.010 Biomarker group BEFREE These results together suggest that the HA-CD44 and activin-A-ALK4 pathways differentially regulate the spheroid formation and maintenance of ALDH<sup>bright</sup> CICs in MM cells, and that both pathways play critical roles in tumor growth in immunodeficient hosts. 30061637 2018
Entrez Id: 93
Gene Symbol: ACVR2B
ACVR2B
0.010 Biomarker group BEFREE The effects of an ActRIIb receptor Fc fusion protein ligand trap in juvenile simian immunodeficiency virus-infected rhesus macaques. 25466897 2015