| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | phenotype | BEFREE | Many authors studied the abnormalities in the protamine 1 (PRM1) and/or protamine 2 (PRM2) genes and reported their possible association with male infertility. | 31286559 | 2019 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | In our study, we examined, for the first time in a Turkish population, the association between protamine gene alleles (PRM1 c.-190C>A, PRM1 c.197G>T, and PRM2 c.248C>T), and YBX2 (c.187T>C and c.1095 + 16A>G) and male infertility. | 29227750 | 2018 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | Our data showed that rs737008 and rs2301365 in <i>PRM1,</i> and rs1646022 in <i>PRM2,</i> were significantly associated with male infertility and that gene-gene interaction played a role in male infertility. | 28977892 | 2017 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | It is reported that defects in the protamine 1 (PRM1) and/or 2 (PRM2) genes cause male infertility. | 27216534 | 2016 | ||||
|
0.080 | AlteredExpression | phenotype | BEFREE | The aim of this study was to give insight into the role of PRM2 gene expression and caspase 9 activity in the pathogenesis of male infertility. | 26392304 | 2016 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis. | 26472740 | 2015 | ||||
|
0.080 | AlteredExpression | phenotype | BEFREE | These data suggest that the decreasing amount of Prm1 and, as a consequence, the aberrant Prm1:Prm2 mRNA ratio plays an important role for male infertility and may serve as a possible predictive factor for the outcome of ICSI. | 12771233 | 2003 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | Although the PRM1 and PRM2 genes are highly conserved, the single SNP in the PRM2 gene that induces translation termination may result in male infertility due to haploinsufficiency of PRM2. | 12569175 | 2003 |