Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE It seems unlikely that IBD-associated polymorphisms in the CARD15, TLR-4, CARD4, SLC22A4, SLC22A5, DLG5, and MDR1 genes confer susceptibility to PSC. 17100974 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE Single nucleotide polymorphisms (SNPs) in multidrug resistance 1 (MDR1) gene encoding transporter P-glycoprotein have been associated with IBD, but their role in disease susceptibility remains unclear. 29543864 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE Since multi-drug resistance 1 gene (MDR1) has a potential influence on Dexamethasone (Dex) bioavailability, we designed this study to investigate the correlation between MDR1 genotype and Dex pharmacokinetic after its delivery in patients with inflammatory bowel disease (IBD). 16494108 2006
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE Moreover, we found that anti-TNF treatment significantly increased ABCB1, leading to levels similar to those found in non-IBD control subjects. 31322753 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE Potential implications of this reduced mechanism of detoxification will be shown for three selected diseases: (1) association of low intestinal P-glycoprotein expression with development of inflammatory bowel disease; (2) implications for disease risk and therapeutic outcome of HIV; and (3) consequences of this mutation for renal P-glycoprotein expression and risk of renal cell carcinoma. 12505329 2002
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE Associations of allelic variants of the multidrug resistance gene (ABCB1 or MDR1) and inflammatory bowel disease and their effects on disease behavior: a case-control and meta-analysis study. 16633048 2006
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE To further elucidate the potential impact of MDR1 two-locus genotypes on susceptibility to IBD and disease behaviour. 17665184 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE We aimed to investigate whether the polymorphisms of five genes including MDR1 influence the response to GC in Chinese patients and the relationship between MDR1 and IBD susceptibility. 25346426 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE ATP-binding cassette transporter ABCG2 (BCRP) and ABCB1 (MDR1) variants are not associated with disease susceptibility, disease phenotype response to medical therapy or need for surgeryin Hungarian patients with inflammatory bowel diseases. 17505995 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE These results indicate the possible involvement of Nrf2-mediated upregulation of P-gp in the therapeutic effect of berberine on colitis and highlight the potential of P-gp and/or Nrf2 as new therapeutic targets for IBD. 29891588 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE Overexpression of MDR1 mRNA in PBMCs of IBD patients is not intrinsic. 15102868 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE We carried out a case-control study to examine the association of MDR1 (C1236T and C3435T), GSTT1, and GSTM1 polymorphisms with the risk of IBD. 26604430 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE Genetic polymorphism of ABCB1 gene (C3435T) in patients with inflammatory bowel diseases. Is there any gender dependency? 25712653 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy. 10648456 2000
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE This meta-analysis indicated that the C3435T polymorphism of MDR1 may not confer susceptibility to IBD. 24449364 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE Genetic analysis of MDR1 and inflammatory bowel disease reveals protective effect of heterozygous variants for ulcerative colitis. 19685447 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression group BEFREE The present study aimed to determine the mRNA levels of MDR1 and COX2 in cats with IBD and LGAL, and to evaluate their correlation with clinical signs, histological severity and between genes. 28948903 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE Dysregulation of P-gp has been implicated in inflammatory bowel disease. 21350189 2011
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE We used coding and noncoding polymorphisms evenly spaced across the ABCB1/MDR1 gene to perform association analysis in Slovenian patients with inflammatory bowel diseases and to obtain haplotype structure and patterns of linkage disequilibrium (LD) in the MDR1 gene. 15505619 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE Thus, the aims of this research were to investigate the association of MDR1 polymorphisms, C3435T and G2677T, and IBD. 23537364 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE The Ala893 variant has decreased activity compared with the 893Ser variant; therefore, the association with human IBD is consistent with the murine model of mdr1 deficiency. 14610718 2003
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker group BEFREE This review focuses on three key molecular mechanisms of glucocorticoid resistance in IBD: (i) decreased cytoplasmic glucocorticoid concentration secondary to increased P-glycoprotein-mediated efflux of glucocorticoid from target cells due to overexpression of the multidrug resistance gene (MDR1); (ii) impaired glucocorticoid signaling because of dysfunction at the level of the glucocorticoid receptor; and (iii) constitutive epithelial activation of proinflammatory mediators, including nuclear factor kappa B, resulting in inhibition of glucocorticoid receptor transcriptional activity. 12967327 2003
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE The MDR1 (multidrug resistance) gene, located on chromosome 7, is in one of the inflammatory bowel disease susceptibility loci. 17242936 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE Polymorphisms of tumor necrosis factor-alpha but not MDR1 influence response to medical therapy in pediatric-onset inflammatory bowel disease. 17255827 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation group BEFREE In order to decrease the uncertainty of pooled risk effects and to explore the trend and stability of the risk effects, a meticulous meta-analysis, including cumulative and recursive cumulative meta-analysis, of the GAS related to the MDR1 gene with susceptibility to IBD was conducted. 21887726 2012