Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Monogenic interleukin-10 (IL-10) and IL-10 receptor (IL-10R) deficiencies cause very early onset severe inflammatory bowel disease. 24089328 2013
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Additionally, clinical experience using interleukin 10-secreting <i>Lc. lactis</i> has been shown to be safe and to facilitate biological containment in IBD therapy. 28179904 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. 19890111 2009
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE The associations in IL10 and IL18R1 are shared with inflammatory bowel disease, suggesting common etiologic pathways. 25200001 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Through plasma-induced signature analysis, we have defined a unique, partially TGF-β/IL-10-dependent immunoregulatory signature associated with IBD that may prove useful in predicting therapeutic responsiveness. 26660358 2016
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE Therefore, polymorphisms of the IL-10 gene are not demonstrably involved in the predisposition of IBD in our cohorts of patients. 11271474 2000
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Interleukin-10 (IL-10) has a key role in regulating mucosal inflammation in inflammatory bowel disease. 16566641 2006
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE This suggests that individuals genetically predisposed to produce less IL-10 are at a higher risk of developing IBD, in particular, UC. 10551422 1999
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE These results indicate that both the <i>IL-10</i> gene itself, and through epistatic interaction with genes within the IL-10/STAT3 signaling pathway, contribute to the risk of pediatric IBD. 28785144 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Here, we review recent findings on how IL10- and IL10R-dependent signaling modulates innate and adaptive immune responses in the murine gastrointestinal tract, with implications of their role in the prevention of inflammatory bowel disease (IBD). 24507158 2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE The role of functional polymorphisms at positions -627 and -1117 in the IL-10 gene as candidate susceptibility loci in inflammatory bowel disease and their importance in determining disease extent were evaluated in 159 patients with ulcerative colitis (83 left-sided; 76 extensive), 90 patients with Crohn's disease (22 small bowel; 29 large bowel; 39 both), and 227 controls. 11478505 2001
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE Interleukin 10 promoter region polymorphisms in inflammatory bowel disease in Tunisian population. 19184348 2009
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE We report that IL-10(-/-) mice, a widely accepted mouse model of IBD, crossed to human MUC1-transgenic mice, develop MUC1(+) IBD characterized by an earlier age of onset, higher inflammation scores, and a much higher incidence and number of colon cancers compared with IL-10(-/-) mice. 17617560 2007
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE IL-10(-/-) mice, an animal model of Th1-mediated inflammatory bowel disease, were screened for the expression of 600 microRNAs (miRNAs) using colonic tissues and PBLs from animals having either mild inflammation or severe intestinal inflammation. 22043014 2011
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE All eight TYK2-deficient patients displayed impaired but not abolished cellular responses to (a) IL-12 and IFN-α/β, accounting for mycobacterial and viral infections, respectively; (b) IL-23, with normal proportions of circulating IL-17(+) T cells, accounting for their apparent lack of mucocutaneous candidiasis; and (c) IL-10, with no overt clinical consequences, including a lack of inflammatory bowel disease. 26304966 2015
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE We performed direct gene sequencing looking for 94 variations in NOD2, ATG16L1, IL23R, IL10R, IL10 and XIAP genes previously shown as correlated with IBD both in multifactorial and in Mendelian models. 29248579 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Genetic and candidate gene analyses in an Il10-deficient IBD mouse model system identified Cd14 as a potentially protective candidate gene. 28411859 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE The anti-inflammatory cytokine IL-10 dampens intestinal inflammation and is therefore a good candidate gene for IBD. 25004811 2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Here, we show that in a murine inflammatory bowel disease (IBD) model based on macrophage-restricted interleukin-10 (IL-10) receptor deficiency (<i>Cx3cr1<sup>Cre</sup>:Il10ra<sup>fl/fl</sup></i> mice), proinflammatory mutant gut macrophages cause severe spontaneous colitis resembling the condition observed in children carrying IL-10R mutations. 31201258 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 AlteredExpression group BEFREE cAT-MSC-secreted TSG-6 ameliorated IBD and regulated colonic expression of pro- and anti-inflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and interleukin-10. 29625582 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE In conclusion, reference drugs with known efficacy in severe inflammatory bowel disease were efficacious in the PAC IL-10 k.o. model. 24797915 2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE ELISA assay and the peripheral blood mononuclear cell (PBMC) cytokine mRNA expression levels were evaluated by quantitative SYBR Green real-time RT-PCR to determine the IL-1beta, TNF-alpha, IFN-gamma and IL-10 secretion in inflammatory bowel diseases patients' PBMC culture supernatants. 20138213 2010
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE However, little is known regarding the role of PI3Kδ on IL-10-producing B cells that help regulate mucosal inflammation in IBD. 31546615 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 AlteredExpression group BEFREE Consistent with the PBMC data, both <i>L. fermentum</i> KBL374- and KBL375-treated DSS mice demonstrated decreased Th1-, Th2-, and Th17-related cytokine levels and increased IL-10 in the colon compared with the DSS control mice.Administration of <i>L. fermentum</i> KBL374 or KBL375 to mice increased the CD4+CD25+Foxp3+Treg cell population in mesenteric lymph nodes.Additionally, <i>L. fermentum</i> KBL374 or KBL375 administration reshaped and increased the diversity of the gut microbiota.In particular, <i>L. fermentum</i> KBL375 increased the abundance of beneficial microorganisms, such as <i>Lactobacillus</i> spp. and <i>Akkermansia</i> spp.Both <i>L. fermentum</i> KBL374 and KBL375 may alleviate inflammatory diseases, such as inflammatory bowel disease, in the gut by regulating immune responses and altering the composition of gut microbiota. 30939976 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Loss of IL-10 promotes the development of inflammatory bowel disease (IBD) as a consequence of an excessive immune response to the gut microbiota. 31727465 2019