| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | group | BEFREE | APC and KRAS were mutated at significantly lower rates in tumors from patients with IBD than in sporadic colorectal tumors (13% and 20% of cases, respectively). | 26764183 | 2016 | ||||
|
0.370 | Biomarker | group | BEFREE | Epigenetic silencing of APC and SFRP2 in the WNT signaling pathway may also be involved in IBD-CRC. | 25773792 | 2015 | ||||
|
0.370 | Biomarker | group | CTD_human | Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia. | 18716850 | 2008 | ||||
|
0.370 | Biomarker | group | BEFREE | The characteristics of Fz and DVL expression in IBD tissues reported herein provides evidence of the importance of Wnt signaling in IBD and IBD-related colon cancer and, specifically, the significance of non-APC components of this pathway. | 17671721 | 2007 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Our aims were to establish the frequency of KLF6 inactivation in sporadic and inflammatory bowel disease (IBD)-associated colorectal cancers (CRC); to correlate these abnormalities with mutation and/or loss of TP53, APC, and K-RAS; and to characterize the behavior of mutant KLF6 in colon-derived cell lines. | 15057748 | 2004 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Lack of an increased APC I1307K carrier rate suggests that this mutation does not account for the increased CRC susceptibility associated with IBD. | 11354631 | 2001 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Low prevalence of the APC I1307K sequence in Jewish and non-Jewish patients with inflammatory bowel disease. | 10445854 | 1999 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Therefore, this model may have some relevance and application to the study of colon cancer in human inflammatory bowel disease, which is not associated with APC mutations or with Ki-ras or p53 mutations. | 9433483 | 1997 |