Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE These results suggest that IL-10 production by ManLAM-treated B cells contributes to keeping the balance between CD4<sup>+</sup> T cell subsets and protect mice from DSS-induced IBD. 31657484 2020
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE The data suggest that endogenous T cell-derived opioids might reduce inflammation-induced abdominal pain in inflammatory bowel diseases associated with homozygous "loss of function mutations" in interleukin-10. 31588671 2020
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE The interleukin-10 knockout (IL-10 KO) mouse is a well-known animal model of IBD that develops spontaneous intestinal inflammation resembling Crohns disease. 31158947 2020
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE SNPs rs1800896, rs3024505 (IL-10); rs11209026 (IL23R); rs2066844, rs2066845 (NOD-2), and rs2241880 (ATG16L1) were assessed in 93 patients with IBD and 200 healthy controls by hybridization probes and quantitative PCR. 31651650 2020
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE These results identify a regulatory interaction between IL-10 and PGE2, dysregulation of which may drive aberrant Mφ activation and impaired host defense contributing to IBD pathogenesis. 31819956 2020
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Here, we show that in a murine inflammatory bowel disease (IBD) model based on macrophage-restricted interleukin-10 (IL-10) receptor deficiency (<i>Cx3cr1<sup>Cre</sup>:Il10ra<sup>fl/fl</sup></i> mice), proinflammatory mutant gut macrophages cause severe spontaneous colitis resembling the condition observed in children carrying IL-10R mutations. 31201258 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE However, little is known regarding the role of PI3Kδ on IL-10-producing B cells that help regulate mucosal inflammation in IBD. 31546615 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 AlteredExpression group BEFREE Consistent with the PBMC data, both <i>L. fermentum</i> KBL374- and KBL375-treated DSS mice demonstrated decreased Th1-, Th2-, and Th17-related cytokine levels and increased IL-10 in the colon compared with the DSS control mice.Administration of <i>L. fermentum</i> KBL374 or KBL375 to mice increased the CD4+CD25+Foxp3+Treg cell population in mesenteric lymph nodes.Additionally, <i>L. fermentum</i> KBL374 or KBL375 administration reshaped and increased the diversity of the gut microbiota.In particular, <i>L. fermentum</i> KBL375 increased the abundance of beneficial microorganisms, such as <i>Lactobacillus</i> spp. and <i>Akkermansia</i> spp.Both <i>L. fermentum</i> KBL374 and KBL375 may alleviate inflammatory diseases, such as inflammatory bowel disease, in the gut by regulating immune responses and altering the composition of gut microbiota. 30939976 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Loss of IL-10 promotes the development of inflammatory bowel disease (IBD) as a consequence of an excessive immune response to the gut microbiota. 31727465 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Ascl2 facilitates IL-10 production in Th17 cells to restrain their pathogenicity in inflammatory bowel disease. 30722992 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE We observed that C3H ASF and 129 ASF IL-10 are more sensitive towardB7 600 μg/mL vitamin B<sub>3</sub> and 1,200 μg/mL vitamin C. The lowest growth rate and viability for all types of organoids was with 1,200 μg/mL vitamin C. From quantitative polymerase chain reaction analysis (qPCR analysis), MUC2 was upregulated for 129 ASF and C3H Conv when exposed to 600 μg/mL and 1,200 μg/mL vitamin C. It suggests that large amounts of glycoprotein may be produced after adding high concentrations of vitamin C. Since inflammatory bowel disease has low level of MUC2, this finding may be helpful in restoring mucosal health by upregulating the MUC2 gene while altering patient's microbiota (Sibila et al., Annals of the American Thoracic Society, 2016). 31071241 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE Mutations in interleukin-10 and its receptors cause infantile inflammatory bowel disease (IBD), a hyperinflammatory disorder characterized by severe, treatment-refractory colitis, multiple abscesses, and enterocutaneous fistulas. 29683948 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE IL10 is an anti-inflammatory cytokine, so Tr1 cells might be used in the treatment of inflammatory bowel diseases. 31513797 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE We investigated two main types of Tregs, the CD4+FOXP3+ and IL-10+ Tr1, in pediatric subjects with inflammatory bowel disease (IBD) both at diagnosis and after the clinical remission. 31715619 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE IL-10-deficient mice and patients with mutations in IL-10 or its receptor, IL-10R, show increased susceptibility to inflammatory bowel diseases (IBD). 31194881 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 AlteredExpression group BEFREE Employing a TNFα-driven murine inflammatory bowel disease (IBD) model (TNF<sup>ΔARE/+</sup>), which mirrors the Treg expansion and transmural ileitis seen in Crohn's disease, we demonstrate that the TNFα-mediated loss of Treg suppressive function coincides with induction of a specific miRNA, miR-106a in both humans and mice, via NFκB promoter binding to suppress post-transcriptional regulation of IL-10 release. 30327532 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE Phenotypic Characterization of Very Early-Onset Inflammatory Bowel Disease with Interleukin-10 Signaling Deficiency: Based on a Large Cohort Study. 30212871 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 GeneticVariation group BEFREE IBD in infants and children under 2 years of age is life-threatening when patients with IL-10R mutations do not receive allogeneic HSCT. 30900524 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Moreover, in Il10-deficient mice with inflammatory bowel disease and normal kidney function, plasma FGF23 was elevated and normalized upon TNF neutralization. 31301888 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE <i>Enterococcus faecalis</i> is a resident member of the human intestinal core microbiota that has been linked to the pathogenesis of IBD and induces chronic colitis in susceptible monoassociated IL-10-deficient (IL-10<sup>-/-</sup>) mice. 31281321 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE The apolipoprotein A-I (APOA1) mimetic 4F mitigated disease in both the Cox2 MKO/CCHF and piroxicam-accelerated Il10-/- models of inflammatory bowel disease (IBD) and reduced elevated levels of pro-inflammatory mediators in tissue and plasma. 31184596 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE This is the first study investigating consequences of hydromorphone in both dextran sodium sulfate (DSS)-induced colitis and spontaneous colitis [IL-10 knockout (IL-10-/-)] mouse model of IBD. 31773170 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE These data indicate that butyrate controls the capacity of T cells in the induction of colitis by differentially regulating Th1 and Th17 cell differentiation and promoting IL-10 production, providing insights into butyrate as a potential therapeutic for the treatment of inflammatory bowel disease. 30918945 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE A better understanding of how IL-10 exerts its suppressive function may allow identification of individuals with suboptimal IL-10 function among the heterogeneous population of IBD patients. 31417161 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.700 Biomarker group BEFREE Collectively, our work identifies Shp2 as a detrimental factor for intestinal immune homeostasis and hopefully will be helpful in the future exploitation of IL-10 immunotherapy for IBD. 30610104 2019