Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE Three-hundred sixty-two gene sets were upregulated, with eight meeting significance (familywise-error rate, FWER p-value <0.05), including the NOD-like receptor inflammasome (NLR; p < 0.001), toll-like receptors (TLR; p < 0.001), IL-1 receptor (p = 0.001), myeloid differentiation primary response gene 88 (p = 0.001), NFkB activation by nontypeable Haemophilus influenzae (p = 0.001), TLR4 (p = 0.008) and TLR 9 (p = 0.018). 23710539 2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE High Pulmonary Levels of IL-6 and IL-1β in Children with Chronic Suppurative Lung Disease Are Associated with Low Systemic IFN-γ Production in Response to Non-Typeable Haemophilus influenzae. 26066058 2015
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE Furthermore, we show that exogenous IL-1β can drastically alter Th1 responses driven by influenza and lymphocytic choriomeningitis virus infection models and induce IL-17 production. 27328989 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE IL-1β is a key cytokine that induces trypsin upregulation in the influenza virus-cytokine-trypsin cycle. 27714503 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 GeneticVariation disease BEFREE Thus, the presence of IL1B-31*C allele plus the presence of S. aureus and/or H. influenzae could be related to the development of tonsillitis in this particular Mexican population. 28542534 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE Influenza elicited a robust IL-1β release that correlated (r=0.6849; p<0.001) with neutrophil infiltrate and was ablated by neutrophil depletion. 29079611 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE Two compounds that showed great anti-inflammatory activity were isolated from C. paniculatum and elucidated as cynanversicoside A and cynanversicoside C. Cytokine assay demonstrated that cynanversicoside A and cynanversicoside C can suppress the production of TNF-α, IL-6 and IL-1β in Mice Pulmonary Microvascular Endothelial Cells (MPMEC) after Influenza virus A/FM/1/47 infection (p < .05) and also decreased the expressions of p-p65 and p-IκBα in infected cells. 29157813 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE IL-1 Signaling Prevents Alveolar Macrophage Depletion during Influenza and <i>Streptococcus pneumoniae</i> Coinfection. 29311363 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE We find that coculture of human PBMCs with inactivated whole influenza virus (A/Victoria/361/2011) in the presence of very low concentrations of IL-15 results in increased production of myeloid cell-derived cytokines, including IL-12, IFN-α2, GM-CSF, and IL-1β, and an increased frequency of polyfunctional NK cells (defined by the expression of two or more of CD107a, IFN-γ, and CD25). 29491009 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE In cultures stimulated with CMV, EBV, influenza and tetanus peptides, the CD4<sup>+</sup> T-cell count correlated with IL-1β (<i>P </i>=<i> </i>0.045) and CD8<sup>+</sup> T-cell count with IFNγ (<i>P </i>=<i> </i>0.013) and IL-1β (<i>P </i>=<i> </i>0.012). 30323928 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE We previously showed that influenza virus M2 or encephalomyocarditis virus (EMCV) 2B proteins stimulate IL-1β secretion following activation of the NLRP3 inflammasome. 30761102 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 GeneticVariation disease BEFREE The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05). 31196204 2019