Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 GeneticVariation disease BEFREE On the contrary, the presence of the TLR4-T399I polymorphism was associated with a 2-fold decreased risk of Haemophilus influenzae carriage (OR = 0.38, 95% CI = 0.15 to 0.96, P = 0.038). 21159925 2011
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE TLR2, TLR3, TLR9 expression increased in the patients with influenza H1N1 2009 infection; no obvious changes of TLR4, TLR7, TLR8 can be detected. 21603856 2012
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE The aim of this study was to evaluate whether selected polymorphisms of TLR2, TLR3 and TLR4 influence the incidence and clinical picture of pandemic A/H1N1/2009 influenza. 23151015 2012
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 AlteredExpression disease BEFREE There were increased cellular expressions of TLR9, TLR8, TLR3, and TLR7 during influenza; TLR2 and TLR4 were suppressed. 23552014 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE Three-hundred sixty-two gene sets were upregulated, with eight meeting significance (familywise-error rate, FWER p-value <0.05), including the NOD-like receptor inflammasome (NLR; p < 0.001), toll-like receptors (TLR; p < 0.001), IL-1 receptor (p = 0.001), myeloid differentiation primary response gene 88 (p = 0.001), NFkB activation by nontypeable Haemophilus influenzae (p = 0.001), TLR4 (p = 0.008) and TLR 9 (p = 0.018). 23710539 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 GeneticVariation disease BEFREE TLR4 1196 C>T effects were similar to TLR4 896 A>G for brucellosis, cutaneous leishmaniasis, leprosy, typhoid fever and S. pyogenes tonsillar disease, and was protective for bacterial vaginosis in pregnancy (0.55; 95%CI 0.31-0.98) and Haemophilus influenzae tonsillar disease (0.42; 95%CI 0.17-1.00). 24282567 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE Therefore, FP7 can antagonize TLR4 activation in vitro and protect mice from severe influenza infection, most likely by reducing TLR4-dependent cytokine storm mediated by damage-associated molecular patterns (DAMPs) like HMGB1. 28106157 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE We previously demonstrated that the combination of synthetic small-molecule Toll-like receptor 4 (TLR4) and TLR7 ligands is a potent adjuvant for recombinant influenza virus hemagglutinin, inducing rapid and sustained immunity that is protective against influenza viruses in homologous, heterologous, and heterosubtypic murine challenge models. 28724768 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE The θ-defensin retrocyclin 101 inhibits TLR4- and TLR2-dependent signaling and protects mice against influenza infection. 28729359 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE To facilitate the generation of NP-specific CTL immunity the authors develop a novel influenza vaccine consisting of virosomes with the Toll-like receptor 4 (TLR4) ligand monophosphoryl lipid A (MPLA) and the metal-ion-chelating lipid DOGS-NTA-Ni incorporated in the membrane. 29278302 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE Treatment of influenza virus-infected mice and cotton rats with the Toll-like receptor 4 (TLR4) antagonist Eritoran blocked DAMP accumulation and ameliorated influenza virus-induced ALI. 29535197 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE Here, we assessed the neonatal adjuvanticity of three novel adjuvants including TLR4 (glucopyranosyl lipid adjuvant-squalene emulsion), TLR9 (IC31<sup>®</sup>), and Mincle (CAF01) agonists, which all induce germinal centers (GCs) and potent antibody responses to influenza hemagglutinin (HA) in adult mice. 29541075 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE All these results demonstrate that MHT can strikingly ameliorate influenza virus A pneumonia in mice, which is associated with the regulating effect of MHT in the imbalance of body's immune function and the MyD88-dependent signaling pathway of TLR4. 29710534 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE Further studies will need to clarify the innate immune responses of neutrophils via TLR4 to prevent NTHi infection. 30055735 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE Increased influenza replication coupled with increases in toll-like receptor 4 (TLR4), phosphorylated nuclear factor κB, and tumor necrosis factor α (TNF-α) levels. 30586993 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 Biomarker disease BEFREE Our findings support the conclusion that selective suppression of CXCL1/CXCL2 represents an IFN-β-mediated "training" of the macrophage transcriptional response to TLR2 agonists and that blocking of TLR4 therapeutically with Eritoran after influenza virus infection reverses this suppression by blunting influenza-induced IFN-β. 31064834 2019