Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 57124
Gene Symbol: CD248
CD248
0.080 Biomarker disease BEFREE β-lactamase production was identified in 27.5 % of NTHi isolates (all TEM-1), while β-lactamase-negative ampicillin resistance and β-lactamase-negative amoxicillin-clavulanate resistance among NTHi was 16.9 and 6.4 %, respectively. 22538797 2012
Entrez Id: 6301
Gene Symbol: SARS1
SARS1
0.100 Biomarker disease BEFREE Zoonoses were already a subject of intense interest even before the SARS and avian influenza epidemics arose. 20358033 2010
Entrez Id: 54938
Gene Symbol: SARS2
SARS2
0.100 Biomarker disease BEFREE Zoonoses were already a subject of intense interest even before the SARS and avian influenza epidemics arose. 20358033 2010
Entrez Id: 81030
Gene Symbol: ZBP1
ZBP1
0.010 Biomarker disease BEFREE ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death. 28634194 2017
Entrez Id: 91543
Gene Symbol: RSAD2
RSAD2
0.330 Biomarker disease BEFREE Young and old viperin-knockout (KO) mice and WT control animals were challenged with influenza WSN33 at lethal doses of 10(3) and 10(4) p.f.u. via the intratracheal route. 22377585 2012
Entrez Id: 1186
Gene Symbol: CLCN7
CLCN7
0.010 AlteredExpression disease BEFREE Wild-type mice or mice lacking the ability to respond to Type 1 IFN were infected with influenza prior to the transfusion of transgenic murine RBCs (K1) expressing the human KEL glycoprotein or the triple fusion HOD protein. 31403208 2019
Entrez Id: 84525
Gene Symbol: HOPX
HOPX
0.010 AlteredExpression disease BEFREE Wild-type mice or mice lacking the ability to respond to Type 1 IFN were infected with influenza prior to the transfusion of transgenic murine RBCs (K1) expressing the human KEL glycoprotein or the triple fusion HOD protein. 31403208 2019
Entrez Id: 3792
Gene Symbol: KEL
KEL
0.010 Biomarker disease BEFREE Wild-type mice or mice lacking the ability to respond to Type 1 IFN were infected with influenza prior to the transfusion of transgenic murine RBCs (K1) expressing the human KEL glycoprotein or the triple fusion HOD protein. 31403208 2019
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
0.010 Biomarker disease BEFREE Wild-type (WT) and Timp1-deficient (Timp1<sup>-/-</sup>) mice that were 8-12 weeks old were administered A/PR/8/34 (PR8), a murine adapted H1N1 influenza virus, and euthanized 6 days after influenza installation. 30167842 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE While wild-type mice induced tumor necrosis factor-a (TNF) after non-typeable H. influenzae challenge, TLR2(-/-) and TLR4(-/-) mice lack TNF induction in the early phase of otitis media. 19586996 2009
Entrez Id: 5307
Gene Symbol: PITX1
PITX1
0.010 AlteredExpression disease BEFREE While the infection had no influence on CpG methylation in the ERVWE1 promoter, chromatin immunoprecipitation assays detected decreased H3K9 trimethylation (H3K9me3) and histone methyltransferase SETDB1 levels along with influenza virus proteins associated with ERVWE1 and other HERV-W loci in infected CCF-STTG1 cells. 24478419 2014
Entrez Id: 9869
Gene Symbol: SETDB1
SETDB1
0.010 AlteredExpression disease BEFREE While the infection had no influence on CpG methylation in the ERVWE1 promoter, chromatin immunoprecipitation assays detected decreased H3K9 trimethylation (H3K9me3) and histone methyltransferase SETDB1 levels along with influenza virus proteins associated with ERVWE1 and other HERV-W loci in infected CCF-STTG1 cells. 24478419 2014
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.030 AlteredExpression disease BEFREE While the infection had no influence on CpG methylation in the ERVWE1 promoter, chromatin immunoprecipitation assays detected decreased H3K9 trimethylation (H3K9me3) and histone methyltransferase SETDB1 levels along with influenza virus proteins associated with ERVWE1 and other HERV-W loci in infected CCF-STTG1 cells. 24478419 2014
Entrez Id: 325
Gene Symbol: APCS
APCS
0.020 Biomarker disease BEFREE While memory CD8(+) T cells specific for CMV and influenza were distributed across SAP(+) and SAP(-) populations, EBV-specific cells were exclusively SAP(+). 22069374 2011
Entrez Id: 4068
Gene Symbol: SH2D1A
SH2D1A
0.010 Biomarker disease BEFREE While memory CD8(+) T cells specific for CMV and influenza were distributed across SAP(+) and SAP(-) populations, EBV-specific cells were exclusively SAP(+). 22069374 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.010 Biomarker disease BEFREE While many viruses are known to downregulate p53 upon entering the cell to reduce the innate host antiviral response, IAV infection is unusual in that it activates p53. 29904383 2018
Entrez Id: 54106
Gene Symbol: TLR9
TLR9
0.070 Biomarker disease BEFREE While macrophages from WT and TLR9-/- mice show similar phagocytosis and bacterial killing to MRSA alone, following influenza infection, there is a marked upregulation of scavenger receptor A and MRSA phagocytosis as well as inducible nitric oxide synthase (Inos) and improved bacterial killing that is specific to TLR9-deficient cells. 30682165 2019
Entrez Id: 143662
Gene Symbol: MUC15
MUC15
0.010 Biomarker disease BEFREE While MUC15 did not interact directly with influenza virus, we showed that its increase coincides with the peak of immune activation and thus MUC15 may serve an immunomodulatory role during influenza infection. 31307416 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.010 Biomarker disease BEFREE Whereas a single immunization with Ad-ASP2 sufficed to completely protect C57BL/6 mice, a higher survival rate was observed in C3H/He mice that were primed with recombinant influenza virus and boosted with Ad-ASP2 after being challenged with T. cruzi. 23637908 2013
Entrez Id: 64006
Gene Symbol: ERVK-6
ERVK-6
0.100 AlteredExpression disease BEFREE When these gradient fractions were treated with 0.01% trypsin for 30 min, the Nagalase activity of each fraction increased significantly, suggesting that the Nagalase activity resides on an outer envelope protein of the influenza virion and is enhanced by the proteolytic process. 15848273 2005
Entrez Id: 110006328
Gene Symbol: ERVK-32
ERVK-32
0.090 AlteredExpression disease BEFREE When these gradient fractions were treated with 0.01% trypsin for 30 min, the Nagalase activity of each fraction increased significantly, suggesting that the Nagalase activity resides on an outer envelope protein of the influenza virion and is enhanced by the proteolytic process. 15848273 2005
Entrez Id: 136991
Gene Symbol: ASZ1
ASZ1
0.010 Biomarker disease BEFREE When testing with other RNA viruses, ORF3 was found to inhibit rescue of porcine respiratory and reproductive syndrome virus (PRRSV), but not of influenza virus. 28474223 2017
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.010 Biomarker disease BEFREE When exposed to chronic cigarette smoke, Aldh2*2 Tg mice were resistant to emphysema development, whereas influenza infection caused more epithelial damage in Aldh2 <sup>-/-</sup> mice than in WT mice. 28431562 2017
Entrez Id: 238
Gene Symbol: ALK
ALK
0.010 GeneticVariation disease BEFREE When comparing the frequencies of antigen-specific memory B-cells analyzed in over 20 screening campaigns, we found a strong correlation of the presence of anti-TIM-3 memory B-cells with memory B-cells expressing mAbs against three disease-associated antigens: (i) bacterial DNABII proteins that are a marker for Gram negative and Gram positive bacterial infections, (ii) hemagglutinin (HA) of influenza virus and (iii) the extracellular domain of anaplastic lymphoma kinase (ALK). 28723950 2017
Entrez Id: 7299
Gene Symbol: TYR
TYR
0.010 Biomarker disease BEFREE We validated these conditions by ELISPOT and intracellular cytokine staining (ICS) assays using peptides from influenza, Epslein-Barr Virus (EBV) and tyrosinase. 17050255 2006