Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE High Level Antibody Response to Pandemic Influenza H1N1/09 Virus Is Associated With Interferon-Induced Transmembrane Protein-3 rs12252-CC in Young Adults. 29868492 2018
Entrez Id: 23586
Gene Symbol: DDX58
DDX58
0.400 Biomarker disease BEFREE Influenza was associated with overexpression of 20 genes, including those encoding the cytokines tumor necrosis factor and IL-12; the kinases MEK, TBK-1, and STAT-1; the apoptosis proteins caspase-8 and caspase-10; the influenza double-stranded RNA receptor RIG-I and its downstream effector MAVS; and pyrin, an IFN-stimulated protein involved in influenza resistance. 24641803 2014
Entrez Id: 4599
Gene Symbol: MX1
MX1
0.400 GeneticVariation disease BEFREE Promoter structure of the MxA gene that confers resistance to influenza virus. 9428735 1997
Entrez Id: 4599
Gene Symbol: MX1
MX1
0.400 Biomarker disease LHGDN Promoted cell death of cells expressing human MxA by influenza virus infection. 11911186 2002
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 Biomarker disease BEFREE Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans. 22446628 2012
Entrez Id: 4599
Gene Symbol: MX1
MX1
0.400 Biomarker disease BEFREE We investigated the importance of the host Mx1 gene in protection against highly pathogenic H5N1 avian influenza virus. 17700072 2007
Entrez Id: 4599
Gene Symbol: MX1
MX1
0.400 Biomarker disease BEFREE Mouse MX1 interacts with the influenza ribonucleoprotein complexes (vRNPs) and can prevent the interaction between polymerase basic 2 (PB2) and the nucleoprotein (NP) of influenza A viruses. 28011636 2017
Entrez Id: 4599
Gene Symbol: MX1
MX1
0.400 Biomarker disease BEFREE Finally, human MX1 (also known as MXA), a closely related protein that has long been recognized as a broadly acting inhibitor of RNA and DNA viruses, including the orthomyxovirus influenza A virus, does not affect HIV-1, whereas MX2 is ineffective against influenza virus. 24048477 2013
Entrez Id: 4599
Gene Symbol: MX1
MX1
0.400 Biomarker disease BEFREE In humans the MxA protein has antiviral activities against influenza viruses. 7551417 1995
Entrez Id: 23586
Gene Symbol: DDX58
DDX58
0.400 Biomarker disease BEFREE Experiments with RIG-I-, MDA5-, and RIG-I/MDA5-deficient mouse fibroblasts showed that RIG-I is the critical pattern recognition receptor needed for the influenza B virus-induced activation of IRF3. 26378160 2015
Entrez Id: 23586
Gene Symbol: DDX58
DDX58
0.400 Biomarker disease BEFREE RIG-I is an innate immune receptor that detects and responds to infection by deadly RNA viruses such as influenza, and Hepatitis C. In the cytoplasm, RIG-I is faced with a difficult challenge: it must sensitively detect viral RNA while ignoring the abundance of host RNA. 28180316 2017
Entrez Id: 23586
Gene Symbol: DDX58
DDX58
0.400 Biomarker disease BEFREE We show here, in the context of an influenza virus infection of lung epithelial cells, that AgNPs down-regulated influenza induced CCL-5 and -IFN-β release (two cytokines important in antiviral immunity) through RIG-I inhibition, while enhancing IL-8 production, a cytokine important for mobilizing host antibacterial responses. 29357226 2018
Entrez Id: 4599
Gene Symbol: MX1
MX1
0.400 Biomarker disease BEFREE One such factor is encoded by the Mx1 gene, which confers resistance to influenza virus infection. 22190720 2012
Entrez Id: 4599
Gene Symbol: MX1
MX1
0.400 Biomarker disease LHGDN Stimulus-dependent and domain-dependent cell death acceleration by an IFN-inducible protein, human MxA. 16704297 2006
Entrez Id: 23586
Gene Symbol: DDX58
DDX58
0.400 Biomarker disease BEFREE LEP and DPEP have certain protective effects on the influenza virus-infected mice, which may be associated with their abilities of effectively alleviating lung injury, improving the immunologic function of infected mice and adjusting the host's TLRs and RIG-1 pathways. 31551774 2019
Entrez Id: 23586
Gene Symbol: DDX58
DDX58
0.400 Biomarker disease BEFREE These findings show that CSE suppresses antiviral and innate immune responses in influenza virus-infected human lungs through oxidative inhibition of viral-mediated induction of the pattern recognition receptor RIG-I. 21335520 2011
Entrez Id: 4599
Gene Symbol: MX1
MX1
0.400 Biomarker disease BEFREE MxA protein confers resistance to influenza viruses, and we have previously shown that MxA protein is strongly expressed in lesional anagen hair bulbs from patients with AA but not in normal follicles. 10942113 2000
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans. 28714988 2017
Entrez Id: 4599
Gene Symbol: MX1
MX1
0.400 Biomarker disease BEFREE Here, we show that, very unexpectedly, congenic D2-Mx1(r/r) mice carrying the wild-type Mx1 gene from the A2G strain are not fully protected against lethal influenza virus infections. 26202236 2015
Entrez Id: 23586
Gene Symbol: DDX58
DDX58
0.400 AlteredExpression disease BEFREE In fact, activation of pathogen sensors induces the expression of CSR32/EGOT RIG-I and the RNA-activated kinase PKR sense HCV RNA, activate NF-κB and upregulate EGOT EGOT is increased in the liver of patients infected with HCV and after infection with influenza or Semliki Forest virus (SFV). 27283940 2016
Entrez Id: 4599
Gene Symbol: MX1
MX1
0.400 AlteredExpression disease BEFREE These results demonstrate for the first time that uncontrolled influenza A virus replication actively suppresses MxA gene expression and emphasize the critical role of innate immunity in controlling influenza virus replication in vivo. 18250448 2008
Entrez Id: 23586
Gene Symbol: DDX58
DDX58
0.400 AlteredExpression disease LHGDN Cutting edge: innate immune response triggered by influenza A virus is negatively regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-dependent pathway. 18250407 2008
Entrez Id: 23586
Gene Symbol: DDX58
DDX58
0.400 Biomarker disease BEFREE In conclusion, our results indicate that influenza NS1 protein targets TRIM25 and Riplet ubiquitin E3 ligases in a species-specific manner for the inhibition of RIG-I ubiquitination and antiviral IFN production. 23209422 2012
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE IFITM3 was sequenced in patients and parents were genotyped for specific variants for family-based association testing. rs12252 was genotyped in 54 African-American pediatric outpatients with influenza (FLU09), included in the population-based comparisons with 1000 genomes. 28531322 2017
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 Biomarker disease BEFREE IFITM3 and severe influenza virus infection. No evidence of genetic association. 27492307 2016