Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7415
Gene Symbol: VCP
VCP
0.010 AlteredExpression disease BEFREE Furthermore, p97 activity has been shown to be essential for the replication of certain viruses, including poliovirus, herpes simplex virus (HSV), cytomegalovirus (CMV), and influenza. 31550150 2020
Entrez Id: 5708
Gene Symbol: PSMD2
PSMD2
0.010 AlteredExpression disease BEFREE Furthermore, p97 activity has been shown to be essential for the replication of certain viruses, including poliovirus, herpes simplex virus (HSV), cytomegalovirus (CMV), and influenza. 31550150 2020
Entrez Id: 10428
Gene Symbol: CFDP1
CFDP1
0.010 AlteredExpression disease BEFREE Furthermore, p97 activity has been shown to be essential for the replication of certain viruses, including poliovirus, herpes simplex virus (HSV), cytomegalovirus (CMV), and influenza. 31550150 2020
Entrez Id: 1982
Gene Symbol: EIF4G2
EIF4G2
0.010 AlteredExpression disease BEFREE Furthermore, p97 activity has been shown to be essential for the replication of certain viruses, including poliovirus, herpes simplex virus (HSV), cytomegalovirus (CMV), and influenza. 31550150 2020
Entrez Id: 50628
Gene Symbol: GEMIN4
GEMIN4
0.010 AlteredExpression disease BEFREE Furthermore, p97 activity has been shown to be essential for the replication of certain viruses, including poliovirus, herpes simplex virus (HSV), cytomegalovirus (CMV), and influenza. 31550150 2020
Entrez Id: 116379
Gene Symbol: IL22RA2
IL22RA2
0.010 Biomarker disease BEFREE Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection. 31597930 2020
Entrez Id: 4594
Gene Symbol: MMUT
MMUT
0.010 GeneticVariation disease BEFREE DTaP5-HB-IPV-Hib is a fully liquid, hexavalent vaccine containing a 5-antigen pertussis component, approved since 2016 in Europe [Vaxelis; DTaP5-HB-IPV-Hib vaccine: Diphtheria, tetanus, pertussis (5 acellular components: pertussis toxoid [PT], filamentous haemagglutinin [FHA], pertactin (PRN), and fimbriae Types 2 and 3 [FIM]), hepatitis B (recombinant DNA: rDNA), poliomyelitis (inactivated) and Haemophilus influenzae type b conjugate vaccine (adsorbed); MCM Vaccine B.V., The Netherlands] for primary and booster vaccination in infants and toddlers against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and invasive diseases caused by Haemophilus influenzae type b. 30882742 2019
Entrez Id: 2919
Gene Symbol: CXCL1
CXCL1
0.010 AlteredExpression disease BEFREE Our findings support the conclusion that selective suppression of CXCL1/CXCL2 represents an IFN-β-mediated "training" of the macrophage transcriptional response to TLR2 agonists and that blocking of TLR4 therapeutically with Eritoran after influenza virus infection reverses this suppression by blunting influenza-induced IFN-β. 31064834 2019
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.010 AlteredExpression disease BEFREE The increased infection severity and inflammatory responses to influenza during pregnancy were associated with a pregnancy-induced shift in AM phenotype at homeostatic baseline, from the M1 (ie, classical activation) state toward the M2 (ie, alternative activation) state, as evidence by increased expression of CD301 and reduced levels of CCR7. 30576502 2019
Entrez Id: 8288
Gene Symbol: EPX
EPX
0.010 GeneticVariation disease BEFREE Interestingly, the EPX gene deletion had no impact on eosinophil-mediated clearance of gram-negative Haemophilus influenzae from the airways. 30285291 2019
Entrez Id: 84296
Gene Symbol: GINS4
GINS4
0.010 AlteredExpression disease BEFREE Moreover, SLD5 partially rescued M1 expression- or influenza virus infection-induced G0/G1 phase accumulation in cell lines and primary mouse embryonic fibroblasts. 31050118 2019
Entrez Id: 4146
Gene Symbol: MATN1
MATN1
0.010 Biomarker disease BEFREE Ultrasensitive Electrical Detection of Hemagglutinin for Point-of-Care Detection of Influenza Virus Based on a CMP-NANA Probe and Top-Down Processed Silicon Nanowire Field-Effect Transistors. 31627298 2019
Entrez Id: 10282
Gene Symbol: BET1
BET1
0.010 Biomarker disease BEFREE BET 1: Oseltamivir use for quicker alleviation of symptoms, fewer hospital admissions and lower mortality in adult patients with influenza B. 30635346 2019
Entrez Id: 3006
Gene Symbol: H1-2
H1-2
0.010 PosttranslationalModification disease BEFREE In addition, HIST1H1C can feedback regulate DNA-dependent protein kinase and euchromatic histone-lysine N-methyltransferase 1/2, leading to altered HIST1H1C phosphorylation and methylation levels, and affecting influenza virus replication accordingly. 31034753 2019
Entrez Id: 28982
Gene Symbol: FLVCR1
FLVCR1
0.010 Biomarker disease BEFREE Re-evaluation of the evolution of influenza H1 viruses using direct PCA. 31848356 2019
Entrez Id: 5716
Gene Symbol: PSMD10
PSMD10
0.010 AlteredExpression disease BEFREE Furthermore, we found that P28 and S65 also affect the shutoff activity of PA-X derived from other influenza virus subtypes. 30894843 2019
Entrez Id: 23038
Gene Symbol: WDTC1
WDTC1
0.010 Biomarker disease BEFREE We also evaluated the efficacy of clopidogrel (CLP), an antagonist of the ADP-P<sub>2</sub>Y<sub>12</sub> platelet receptor, alone or in combination with an antiviral agent (oseltamivir) against influenza infection in mice. 31070937 2019
Entrez Id: 7190
Gene Symbol: HSP90B2P
HSP90B2P
0.010 Biomarker disease BEFREE Chimeric protein consisting of 3M2e and HSP as a universal influenza vaccine candidate: from in silico analysis to preliminary evaluation. 30382564 2019
Entrez Id: 10462
Gene Symbol: CLEC10A
CLEC10A
0.010 AlteredExpression disease BEFREE The increased infection severity and inflammatory responses to influenza during pregnancy were associated with a pregnancy-induced shift in AM phenotype at homeostatic baseline, from the M1 (ie, classical activation) state toward the M2 (ie, alternative activation) state, as evidence by increased expression of CD301 and reduced levels of CCR7. 30576502 2019
Entrez Id: 2922
Gene Symbol: GRP
GRP
0.010 Biomarker disease BEFREE Antagonizing GRP or its receptor mitigated lethality associated with the onset of viral pneumonia in a well-characterized mouse model of influenza. 30327535 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.010 Biomarker disease BEFREE Among influenza patients, there were significant but weak correlations between CoQ10 levels and IL-2 (r = -.30, P = .04), TNF-alpha (r = -.35, P = .01) and VEGF (r = .38, P = .007), but no correlation with IL-6, IL-10, VCAM or influenza severity of illness score (all P > .05). 30156030 2019
Entrez Id: 51297
Gene Symbol: BPIFA1
BPIFA1
0.010 AlteredExpression disease BEFREE We performed Western blotting to determine SPLUNC1 levels and determined antimicrobial activity against nontypeable Haemophilus influenzae. 31113421 2019
Entrez Id: 643
Gene Symbol: CXCR5
CXCR5
0.010 Biomarker disease BEFREE Altered proportions of circulating CXCR5+ helper T cells do not dampen influenza vaccine responses in children with rheumatic disease. 31126860 2019
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.010 Biomarker disease BEFREE Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection. 30455472 2019
Entrez Id: 100302236
Gene Symbol: MIR1260A
MIR1260A
0.010 Biomarker disease BEFREE To date, numerous biomarkers have been identified for the diagnostic or prognostic purpose; for instance, miR-182, miR-486, and miR15a in sepsis; miR-320 and miR505 in inflammatory bowel disease; miR-155 and miR-1260 in influenza; miR-12, miRVP-3p, and miR-184 in arboviruses; and miR-29b and miR-125 in hepatitis infection. 30146762 2019