Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 AlteredExpression disease BEFREE Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection. 30650117 2019
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE In recent years a single nucleotide polymorphism, interferon-induced transmembrane protein 3 (IFITM3) rs12252, has been shown to alter the severity of influenza infection in Asian populations. 30987701 2019
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 AlteredExpression disease BEFREE IFITM3 was markedly upregulated in platelets isolated from patients during clinical influenza and dengue virus (DENV) infections. 30723081 2019
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE High Level Antibody Response to Pandemic Influenza H1N1/09 Virus Is Associated With Interferon-Induced Transmembrane Protein-3 rs12252-CC in Young Adults. 29868492 2018
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE We analyzed the population genetics of IFITM3 variants in the Portuguese general population (n = 200) and Central Africans (largely Angolan) (n = 148) as well as its association to influenza severity in Portuguese patients (n = 41). 28842783 2018
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes. 29202190 2018
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE Recent studies suggested, the rs12252 T > C polymorphism in the interferon-inducible transmembrane protein 3 (IFITM3) gene might be associated with susceptibility to severe influenza. 29940276 2018
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE To further understand the association between the SNP of IFITM3 and the risk of influenza, we searched related studies in five databases including PubMed published earlier than 9 November 2017. 30421689 2018
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans. 28714988 2017
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE IFITM3 was sequenced in patients and parents were genotyped for specific variants for family-based association testing. rs12252 was genotyped in 54 African-American pediatric outpatients with influenza (FLU09), included in the population-based comparisons with 1000 genomes. 28531322 2017
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 Biomarker disease BEFREE Consistent with the known ability of amphipathic helices to alter membrane properties, we show that this helix and its amphipathicity are required for the IFITM3-dependent inhibition of influenza virus, Zika virus, vesicular stomatitis virus, Ebola virus, and human immunodeficiency virus infections. 28835547 2017
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 Biomarker disease BEFREE IFITM3 and severe influenza virus infection. No evidence of genetic association. 27492307 2016
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection. 27351739 2016
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE Stratification analysis of ethnicity and severity revealed a significant increase in influenza susceptibility by IFITM3-SNP rs12252 among both Asian and Caucasian population. 25942469 2015
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 Biomarker disease BEFREE Clustering of gene expression profiles suggests IFITM1 and 2 have an anti-viral response and IFITM3 may restrict avian influenza virus through cell membrane fusion. 26238195 2015
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 Biomarker disease BEFREE Furthermore, entry mediated by the influenza virus hemagglutinin was robustly inhibited by IFITM3 but was insensitive to accumulation of endosomal cholesterol, indicating that modulation of cholesterol synthesis/transport did not account for the antiviral activity of IFITM3. 25256397 2014
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumonia, and >5000 individuals comprising patients with community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry. 23997235 2014
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 Biomarker disease CTD_human A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2. 23326326 2013
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 GeneticVariation disease BEFREE Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent. 23361009 2013
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 Biomarker disease BEFREE One study does however present convincing functional evidence for an important role for IFITM3 in susceptibility to severe influenza in mice, and some evidence that this may also be important in human A/H1N1/pdm2009 infection. 24034482 2013
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 Biomarker disease BEFREE Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans. 22446628 2012
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 Biomarker disease BEFREE S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus. 22511783 2012
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 Biomarker disease BEFREE Collectively, these findings establish a central role for Ifitm3 in limiting acute influenza in vivo, and provide further insight into Ifitm3 expression and regulation. 22969429 2012
Entrez Id: 10410
Gene Symbol: IFITM3
IFITM3
0.400 Biomarker disease BEFREE Tetherin and IFITM3 are recently identified interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. 20943977 2010